The P3 Event-Related Potential is a Biomarker for the Efficacy of Vagus Nerve Stimulation in Patients with Epilepsy

Taeye, Leen De; Vonck, Kristl; Bochove, Marlies van; Boon, Paul; Roost, Dirk Van; Mollet, Lies; Meurs, Alfred; Herdt, Veerle De; Carrette, Evelien; Dauwe, Ine; Gadeyne, Stefanie; Mierlo, Pieter van; Verguts, Tom; Raedt, Robrecht

doi:10.1007/s13311-014-0272-3

Cited by 72 publications

(61 citation statements)

References 56 publications

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“…The link between the phasic LC-NE response and the centroparietal P3 is supported by a wealth of neurophysiological evidence [35–37,83,84]. This link may in part be mediated by DA release in the cortex, where noradrenergic terminals co-release DA [39].…”

Section: Discussionmentioning

confidence: 99%

Catecholaminergic Regulation of Learning Rate in a Dynamic Environment

et al. 2016

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Adaptive behavior in a changing world requires flexibly adapting one’s rate of learning to the rate of environmental change. Recent studies have examined the computational mechanisms by which various environmental factors determine the impact of new outcomes on existing beliefs (i.e., the ‘learning rate’). However, the brain mechanisms, and in particular the neuromodulators, involved in this process are still largely unknown. The brain-wide neurophysiological effects of the catecholamines norepinephrine and dopamine on stimulus-evoked cortical responses suggest that the catecholamine systems are well positioned to regulate learning about environmental change, but more direct evidence for a role of this system is scant. Here, we report evidence from a study employing pharmacology, scalp electrophysiology and computational modeling (N = 32) that suggests an important role for catecholamines in learning rate regulation. We found that the P3 component of the EEG—an electrophysiological index of outcome-evoked phasic catecholamine release in the cortex—predicted learning rate, and formally mediated the effect of prediction-error magnitude on learning rate. P3 amplitude also mediated the effects of two computational variables—capturing the unexpectedness of an outcome and the uncertainty of a preexisting belief—on learning rate. Furthermore, a pharmacological manipulation of catecholamine activity affected learning rate following unanticipated task changes, in a way that depended on participants’ baseline learning rate. Our findings provide converging evidence for a causal role of the human catecholamine systems in learning-rate regulation as a function of environmental change.

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Section: Discussionmentioning

confidence: 99%

Catecholaminergic Regulation of Learning Rate in a Dynamic Environment

et al. 2016

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“…The locus coeruleus is mainly known for its role in norepinephrine release and the orienting response, thought to be marked by the widening of pupils and an event-related electrophysiological component called the P3 (De Taeye et al, 2014;Geva, Zivan, Warsha, & Olchik, 2013;Murphy, Robertson, Balsters, & O'Connell, 2011;Nieuwenhuis, Aston-Jones, & Cohen, 2005;Nieuwenhuis, De Geus, & Aston-Jones, 2011). This orienting response is typically elicited by infrequent and motivationally significant stimuli and serves to facilitate further behavioral adaptations (Lynn, 1966).…”

Section: Discussionmentioning

confidence: 99%

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Braem

Coenen

Bombeke

et al. 2015

Cogn Affect Behav Neurosci

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Previous studies have demonstrated that autonomic arousal is increased following correct task performance on a difficult, relative to an easy, task. Here, we hypothesized that this arousal response reflects the (relative) surprise of correct performance following a difficult versus an easy task. Following this line of reasoning, we would expect to find a reversed pattern following erroneous responses, because errors are less expected during an easy than during a difficult task. To test this, participants performed a flanker task while pupil size was measured online. As predicted, the results demonstrated that pupil size was larger following difficult (incongruent) correct trials than following easy (congruent) correct trials, but smaller following difficult than following easy incorrect trials. Moreover, participants with larger congruency effects, and hence a larger difference in outcome expectancies between the two trial types, showed larger differences in pupil size after both correct and incorrect responses, further corroborating the idea that pupil size increased as a measure of performance prediction errors.

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“…15 The P3 component of the event-related potential (ERP), a biomarker for predicting VNS response in epilepsy, reflects the phasic activity of the neuromodulatory LC-NE system. 16 Bilateral LC lesions suppress the VNS anti-seizure effect, suggesting a key role of the LC in seizure modulation. 17 Giorgi et al stated that the LC plays a critical role in modulating epilepsy-related synaptic plasticity gene expression.…”

Section: Recent Trials and Research On Vnsmentioning

confidence: 99%

“…VNS increased extracellular hippocampal NE, which is a potential biomarker for the efficacy of VNS in temporal lobe epilepsy . The P3 component of the event‐related potential (ERP), a biomarker for predicting VNS response in epilepsy, reflects the phasic activity of the neuromodulatory LC‐NE system . Bilateral LC lesions suppress the VNS anti‐seizure effect, suggesting a key role of the LC in seizure modulation .…”

Section: Recent Trials and Research On Vnsmentioning

confidence: 99%

Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part III

2015

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Vagus nerve stimulation (VNS) is currently undergoing multiple trials to explore its potential for various clinical disorders. To date, VNS has been approved for the treatment of refractory epilepsy and depression. It exerts antiepileptic or antiepileptogenic effect possibly through neuromodulation of certain monoamine pathways. Beyond epilepsy, VNS is also under investigation for the treatment of inflammation, asthma, and pain. VNS influences the production of inflammatory cytokines to dampen the inflammatory response. It triggers the systemic release of catecholamines that alleviates the asthma attack. VNS induces antinociception by modulating multiple pain-associated structures in the brain and spinal cord affecting peripheral/central nociception, opioid response, inflammation process, autonomic activity, and pain-related behavior. Progression in VNS clinical efficacy over time suggests an underlying disease-modifying neuromodulation, which is an emerging field in neurology. With multiple potential clinical applications, further development of VNS is encouraging.

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The P3 Event-Related Potential is a Biomarker for the Efficacy of Vagus Nerve Stimulation in Patients with Epilepsy

Cited by 72 publications

References 56 publications

Catecholaminergic Regulation of Learning Rate in a Dynamic Environment

Catecholaminergic Regulation of Learning Rate in a Dynamic Environment

Open your eyes for prediction errors

Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part III

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