Evaluation Patch of Rhizoma Extract Kencur (Kaempferia galanga L.) as Anti-Inflammatory with Enhancer

Abstract

Kencur (Kaempferia galanga L.) is a family of Zingiberaceae. Several studies have shown that kencur can help reduce inflammation because kencur is known to contain anti-inflammatory compounds, namely marker compounds from flavonoids, kaempferol. For the development of pharmaceutical preparations, research on anti-inflammatory plasters containing 96% ethanol extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from ginger rhizome with the addition of penetration enhancer (enhancer), namely propylene glycol. This anti-inflammatory plaster was tested for its activity in 5 groups of Wistar strain rat feet which had been induced 1% carrageenan (negative control); positive control (diclofenac sodium), ethanol96% extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from kencur rhizome and compared with plaster of kencur rhizome ethanol extract without enhancer. The results showed the effect of adding enhancers 30 minutes after administration. 96% ethanol extract and ethyl acetate extract had reduced inflammation by 79.99% in rat test animals compared to plaster ethanol extract of rhizome kencur without the addition of enhancers. Keywords : Kaempferia galanga. L., patch, anti-inflammatory, enhancer, propylene glycol

Skrining Fitokimia, Antioksidan dan Aktivitas Antibakteri Ekstrak Etanol Akar Segar Bangle (Zingiber montanum)

“…Serbuk akar segar bangle (Z. montanum) sebanyak 417 gram dimaserasi dengan 800 mL pelarut etanol 96% selama 3 hari sampai warnanya bening. Hasil maserat yang diperoleh diuapkan dengan rotary evaporator pada suhu 40-50 0 C dan maserat dipanaskan di atas penangas air pada suhu ± 50 0 C hingga didapatkan ekstrak kental yang akan digunakan untuk uji fitokimia, antioksidan dan uji antimikroba (Riasari et al, 2019).…”

Potensi Antiinflamasi Tanaman Kaempferia

“…Pengujian secara in vitro yang telah dilakukan juga membuktikan bahwa ekstrak dari daun Kaempferia galanga memiliki potensi sebagai antiinflamasi [15]. Dalam formulasi sediaan patch, ekstrak Kaempferia galanga terbukti dapat mengurangi inflamasi dengan dosis 18 mg sebagai dosis yang efektif [16]. Formulasi sediaan salep juga membuktikan bahwa Kaempferia galanga dengan konsentrasi 15% efektif untuk mengurangi inflamasi pada tikus [17].…”

Chemical Components Analysis of Kencur (Kaempreria galanga L) Essential Oil Using GC-MS Method and Its Insecticide Tests on Fruit Fly (Bactrocera sp.)

“…Research that has been conducted in various countries shows that essential oils from multiple plants are not only able to repel insect pests but also show inhibition of consumption by these insects [5]. Results of previous research: Test the effect of instant Kencur powder (Kaempferia galanga L.) as a tonic on swiss webster strain male mice [6].…”