Evaluation of vitamin C protective effect on the cerebrocortical antioxidant defense, histopathological, pro-apoptotic p53 and anti-apoptotic Bcl2 expressions against tramadol neurotoxicity in rats

Kader, Ghada Abdel; Ibrahim, Mahrous A.; Khalifa, Athar M.; Mirza, Umrana; Rashwan, Eman K.; Abdel-Hady, Zinab

doi:10.1016/j.jchemneu.2020.101893

Cited by 3 publications

(2 citation statements)

References 55 publications

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“…Moreover, Mhaidat et al [36] discovered that vitamin C administration during sleep deprivation antagonizes spatial memory dysfunction caused by diminished primary molecules and enzymes involved in antioxidant defense including the GSH/GSSG ratio and other antioxidants. In addition, Kader et al [37] stated that the ameliorative effects of vitamin C in toxicity prevention mainly come from its ability for scavenging overproduced reactive oxygen species.…”

Section: Discussionmentioning

confidence: 99%

Potential of Ascorbic Acid Supplements to Ameliorate the Deleterious Effects of Hyperuricemia on Albino Wistar Rats’ Hippocampus (Structural and Functional Study)

Ahmed¹,

Mona²,

Elsisy³

et al. 2023

Neuroendocrinology

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Introduction: Diet rich in purines may increase the serum level of uric acid causing hyperuricemia contributing learning and memory to impairments. Ascorbic acid has a potent antioxidant potential. The hippocampus is a pivotal component of human brains and other vertebrates that plays crucial roles in the consolidation of information and spatial memory. Our study was mainly designated to examine the potential palliative role of ascorbic acid supplements on harmful effects induced hyperuricemia on the hippocampus of albino Wistar rats. Methods: Forty rats were subgrouped into: Control group, Ascorbate only group, Hyperuricemic group and Combined hyperuricemia and ascorbate group. Results: Ascorbic acid has strongly preserved the histological architecture and maintained the normal hippocampal functions in hyperuricemic group. Discussion/ Conclusion: The anti-inflammatory and antioxidant properties of ascorbic acid could protect the hippocampus of albino Wistar rats against the hazardous impact of hyperuricemia.

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Section: Discussionmentioning

confidence: 99%

Potential of Ascorbic Acid Supplements to Ameliorate the Deleterious Effects of Hyperuricemia on Albino Wistar Rats’ Hippocampus (Structural and Functional Study)

Ahmed¹,

Mona²,

Elsisy³

et al. 2023

Neuroendocrinology

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“…The explanation for this could be related to the mechanism of tissue accumulation of ascorbate and the balance of its alimentary and endogenous availability. Hence, the rat model has been used in various earlier studies to test the beneficial role of VC oral dosing to rescue oxidative stress conditions resulting from exposure to various toxicants (Mekkawy et al, 2020;Kader et al, 2021;Shotop and Al-Suwiti, 2021). Herein, the co-treatment with VC significantly improved the oxidative status induced by BLD injection.…”

Section: Discussionmentioning

confidence: 99%

Boldenone Undecylenate-Mediated Hepatorenal Impairment by Oxidative Damage and Dysregulation of Heat Shock Protein 90 and Androgen Receptors Expressions: Vitamin C Preventive Role

Behairy¹,

Mohamed²,

Ebraheim³

et al. 2021

Front. Pharmacol.

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Boldenone Undecylenate (BLD) is a synthetic derivative of testosterone and a widely used anabolic androgenic steroid. The health risk of BLD use as a pharmaceutical or dietary supplement is still underestimated and under-reported. Vitamin C (VC) has been recognized as an antioxidant with prominent hepatorenal protective effects. This study investigated the possible preventive activity of VC against BLD-induced hepatorenal damage. Forty adult male Wistar rats were classified into five groups: control, vehicle control, VC (orally given 120 mg/kg b. wt./day), BLD (intramuscularly injected 5 mg/kg b. wt./week), and BLD + VC-treated groups. The experiment continued for eight weeks. Serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured. Serum contents of total protein (TP), albumin (ALB), globulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and very-low-density lipoprotein–cholesterol (VLDL-C) were also assayed. Urea, creatinine, and uric acid levels were determined together with sodium and potassium electrolytes measuring. Moreover, oxidative stress indicators including reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and glutathione reductase (GSR) as well as malondialdehyde (MDA) levels were measured in both hepatic and renal tissues. Corresponding histological examination of renal and hepatic tissues was conducted. Besides, immunohistochemical evaluations for androgen receptors protein (AR) and heat shock protein 90 (Hsp 90) expressions were performed. BLD caused significant rises in serum ALT, AST, TP, ALB, TC, TG, LDL-C, VLDL-C, urea, creatinine, uric acid, potassium, and MDA levels. Further, BLD-injected rats showed significant declines in the serum levels of HDL-C, sodium, GSH, GPx, GST, and GSR. Besides, distinct histopathological perturbations were detected in renal and hepatic tissues of BLD-injected rats. AR and Hsp 90 immunoexpression were increased in hepatic and renal tissues. In contrast, VC significantly reversed the BLD-induced hepatorenal damage in co-treated rats but not ameliorated AR protein overexpression. VC could be an efficient preventive supplement for mitigating BLD-induced hepatorenal damage, possibly via controlling oxidative stress events.

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Nano-TiO2 aggravates bioaccumulation and developmental neurotoxicity of difenoconazole in zebrafish larvae via oxidative stress and apoptosis: Protective role of vitamin C

Renfei

Liu

Wang

et al. 2023

Ecotoxicology and Environmental Safety

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Evaluation of vitamin C protective effect on the cerebrocortical antioxidant defense, histopathological, pro-apoptotic p53 and anti-apoptotic Bcl2 expressions against tramadol neurotoxicity in rats

Cited by 3 publications

References 55 publications

Potential of Ascorbic Acid Supplements to Ameliorate the Deleterious Effects of Hyperuricemia on Albino Wistar Rats’ Hippocampus (Structural and Functional Study)

Potential of Ascorbic Acid Supplements to Ameliorate the Deleterious Effects of Hyperuricemia on Albino Wistar Rats’ Hippocampus (Structural and Functional Study)

Boldenone Undecylenate-Mediated Hepatorenal Impairment by Oxidative Damage and Dysregulation of Heat Shock Protein 90 and Androgen Receptors Expressions: Vitamin C Preventive Role

Nano-TiO2 aggravates bioaccumulation and developmental neurotoxicity of difenoconazole in zebrafish larvae via oxidative stress and apoptosis: Protective role of vitamin C

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