Nano-TiO2 aggravates bioaccumulation and developmental neurotoxicity of difenoconazole in zebrafish larvae via oxidative stress and apoptosis: Protective role of vitamin C

Renfei, ZHU; Liu, Chunlan; Wang, Jingyu; Zou, Li; Yang, Fan; Chi, Xia; Zhu, Jiansheng

doi:10.1016/j.ecoenv.2023.114554

Cited by 14 publications

(4 citation statements)

References 44 publications

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“…The most commonly used dose of TiO 2 NPs in studies involving co-exposure to other compounds was 100 μg/L. So far, TiO 2 NPs have been shown to enhance Pb, 106 , 107 decabromodiphenyl oxide (BDE-209), 108 cypermethrin, 109 triphenyl phosphate, 110 bisphenol A, 111 , 112 difenoconazole, 113 tetracycline, 114 and microcystin-LR 115 -induced neurotoxicity. TiO 2 NPs mainly enhance the neurotoxicity of these compounds by increasing their bioconcentration and bioavailability in zebrafish.…”

Section: Neurotoxic Effects Of Tio 2 Nps In Zebrafishmentioning

confidence: 99%

Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review

Zhang,

Song,

Gong

et al. 2023

IJN

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The increasing use of titanium dioxide nanoparticles (TiO 2 NPs) across various fields has led to a growing concern regarding their environmental contamination and inevitable human exposure. Consequently, significant research efforts have been directed toward understanding the effects of TiO 2 NPs on both humans and the environment. Notably, TiO 2 NPs exposure has been associated with multiple impairments of the nervous system. This review aims to provide an overview of the documented neurotoxic effects of TiO 2 NPs in different species and in vitro models. Following exposure, TiO 2 NPs can reach the brain, although the specific mechanism and quantity of particles that cross the blood-brain barrier (BBB) remain unclear. Exposure to TiO 2 NPs has been shown to induce oxidative stress, promote neuroinflammation, disrupt brain biochemistry, and ultimately impair neuronal function and structure. Subsequent neuronal damage may contribute to various behavioral disorders and play a significant role in the onset and progression of neurodevelopmental or neurodegenerative diseases. Moreover, the neurotoxic potential of TiO 2 NPs can be influenced by various factors, including exposure characteristics and the physicochemical properties of the TiO 2 NPs. However, a systematic comparison of the neurotoxic effects of TiO 2 NPs with different characteristics under various exposure conditions is still lacking. Additionally, our understanding of the underlying neurotoxic mechanisms exerted by TiO 2 NPs remains incomplete and fragmented. Given these knowledge gaps, it is imperative to further investigate the neurotoxic hazards and risks associated with exposure to TiO 2 NPs.

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Section: Neurotoxic Effects Of Tio 2 Nps In Zebrafishmentioning

confidence: 99%

Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review

Zhang,

Song,

Gong

et al. 2023

IJN

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“…The impact of the neurotoxic agent can also be evaluated by analysing the expression of genes associated with neuronal development and differentiation ( Supplementary Table S2 ). These genes encompass immature neuronal markers like nestin ( Chen et al, 2012 ; Ho et al, 2013 ; Soares et al, 2017 ; Qian et al, 2018 ; Cheng et al, 2020 ; Xia et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Yu et al, 2022 ; Xu et al, 2023 ), as well as mature neuronal markers like growth associated protein 43 ( gap43 ) ( Chen et al, 2012 ; Sun et al, 2016 ; Soares et al, 2017 ; Faria et al, 2018 ; Qian et al, 2018 ; Shi et al, 2018 ; Jin et al, 2019b ; Li et al, 2019 ; Cheng et al, 2020 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Li et al, 2021 ; Tian et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Yu et al, 2022 ; Shi et al, 2023 ; Xiong et al, 2023 ; Xu et al, 2023 ; Zhu et al, 2023 ), and elav like RNA binding protein 3 ( elavl3 ) ( Chen et al, 2012 ; Sun et al, 2016 ; Qian et al, 2018 ; Shi et al, 2018 ; Yang et al, 2019 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Wang et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Fan et al, 2022 ; Wang et al, 2022 ; Yu et al, 2022 ; Xiong et al, 2023 ; Zhu et al, 2023 ). Additionally, astrocyte markers such as glial fibrillary acidic protein ( gfap ) ( Chen et al, 2012 ; Sun et al, 2016 ; Soares et al, 2017 ; ...…”

Section: Neurotoxic Effect On Embryonic Developmentmentioning

confidence: 99%

“…In zebrafish, the impact of neurotoxic substances on oxidative stress can be studied by analysing the expression and the activity of these enzymes or other markers related to the oxidative stress ( Figure 2 ). For instance, neurotoxicity studies in zebrafish have analysed the gene expression of sod1 ( Powers et al, 2017 ; Cao et al, 2019 ; Ding et al, 2023 ; Zhu et al, 2023 ), sod2 ( Sarasamma et al, 2018 ; Cao et al, 2019 ; Wu et al, 2021 ; Ji et al, 2021 ; Patel et al, 2021 ; Haridevamuthu et al, 2022 ; Orozco-Hernandez et al, 2022 ), cat ( Gu et al, 2021 ; Ji et al, 2021 ; Haridevamuthu et al, 2022 ; Orozco-Hernandez et al, 2022 ; Kachot and Patel, 2023 ; Zhu et al, 2023 ) and gpx ( gpx1a and gpx4a ) ( Ji et al, 2021 ; Haridevamuthu et al, 2022 ; Orozco-Hernandez et al, 2022 ; Ding et al, 2023 ), gst ( Haridevamuthu et al, 2022 ), gsr ( Haridevamuthu et al, 2022 ), gclm ( Wu et al, 2021 ; Ji et al, 2021 ; Chian et al, 2022 ) and gsto2 ( Ji et al, 2021 ). For example, reduced sod expression was observed following treatment with cadmium chloride ( Pan et al, 2018 ), zinc chloride ( Sarasamma et al, 2018 ), mercury chloride ( Patel et al, 2021 ), fipronil ( Wu et al, 2021 ), acrylamide ( Haridevamuthu et al, 2022 ), while lead ( Ji et al, 2021 ) and fluoxetine ( Orozco-Hernandez et al, 2022 ) led to an increase in sod expression.…”

Section: Oxidative Stressmentioning

confidence: 99%

“…Gene expression analysis related to axons has demonstrated alteration in the expression of regeneration-associated genes such as growth-associated protein Gap-43 ( gap43 ) ( Chen et al, 2012 ; Sun et al, 2016 ; Soares et al, 2017 ; Faria et al, 2018 ; Qian et al, 2018 ; Shi et al, 2018 ; Jin et al, 2019b ; Li et al, 2019 ; Cheng et al, 2020 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Li et al, 2021 ; Tian et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Chang et al, 2022 ; Yu et al, 2022 ; Shi et al, 2023 ; Xiong et al, 2023 ; Xu et al, 2023 ; Zhu et al, 2023 ) and α1 tubulin ( Sun et al, 2016 ; Li et al, 2018 ; Shi et al, 2018 ; Yang et al, 2019 ; Fu et al, 2020 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Heredia-García et al, 2023 ; Shi et al, 2023 ; Xu et al, 2023 ). Additionally, nerve related genes like pax6a ( Ho et al, 2013 ; Li et al, 2019 ; Wang et al, 2021 ; Gyimah et al, 2022 ), elavl3 ( Chen et al, 2012 ; Sun et al, 2016 ; Qian et al, 2018 ; Shi et al, 2018 ; Yang et al, 2019 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Wang et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Fan et al, 2022 ; Wang et al, 2022 ; Yu et al, 2022 ;…”

Section: Morphology and Characteristics Of Neuronsmentioning

confidence: 99%

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Temperature- and chemical-induced neurotoxicity in zebrafish

Toni,

Arena,

Cioni

et al. 2023

Front. Physiol.

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Throughout their lives, humans encounter a plethora of substances capable of inducing neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests when exposure to these chemicals disrupts the normal functioning of the nervous system, and some neurotoxic agents have been linked to neurodegenerative pathologies such as Parkinson’s and Alzheimer’s disease. The growing concern surrounding the neurotoxic impacts of both naturally occurring and man-made toxic substances necessitates the identification of animal models for rapid testing across a wide spectrum of substances and concentrations, and the utilization of tools capable of detecting nervous system alterations spanning from the molecular level up to the behavioural one. Zebrafish (Danio rerio) is gaining prominence in the field of neuroscience due to its versatility. The possibility of analysing all developmental stages (embryo, larva and adult), applying the most common “omics” approaches (transcriptomics, proteomics, lipidomics, etc.) and conducting a wide range of behavioural tests makes zebrafish an excellent model for neurotoxicity studies. This review delves into the main experimental approaches adopted and the main markers analysed in neurotoxicity studies in zebrafish, showing that neurotoxic phenomena can be triggered not only by exposure to chemical substances but also by fluctuations in temperature. The findings presented here serve as a valuable resource for the study of neurotoxicity in zebrafish and define new scenarios in ecotoxicology suggesting that alterations in temperature can synergistically compound the neurotoxic effects of chemical substances, intensifying their detrimental impact on fish populations.

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Research advance of occupational exposure risks and toxic effects of semiconductor nanomaterials

Wu,

Ding,

Pang

et al. 2024

J of Applied Toxicology

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In recent years, semiconductor nanomaterials, as one of the most promising and applied classes of engineered nanomaterials, have been widely used in industries such as photovoltaics, electronic devices, and biomedicine. However, occupational exposure is unavoidable during the production, use, and disposal stages of products containing these materials, thus posing potential health risks to workers. The intricacies of the work environment present challenges in obtaining comprehensive data on such exposure. Consequently, there remains a significant gap in understanding the exposure risks and toxic effects associated with semiconductor nanomaterials. This paper provides an overview of the current classification and applications of typical semiconductor nanomaterials. It also delves into the existing state of occupational exposure, methodologies for exposure assessment, and prevailing occupational exposure limits. Furthermore, relevant epidemiological studies are examined. Subsequently, the review scrutinizes the toxicity of semiconductor nanomaterials concerning target organ toxicity, toxicity mechanisms, and influencing factors. The aim of this review is to lay the groundwork for enhancing the assessment of occupational exposure to semiconductor nanomaterials, optimizing occupational exposure limits, and promoting environmentally sustainable development practices in this domain.

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Nano-TiO2 aggravates bioaccumulation and developmental neurotoxicity of difenoconazole in zebrafish larvae via oxidative stress and apoptosis: Protective role of vitamin C

Cited by 14 publications

References 44 publications

Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review

Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review

Temperature- and chemical-induced neurotoxicity in zebrafish

Research advance of occupational exposure risks and toxic effects of semiconductor nanomaterials

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