Evaluation of Vertebral Bone Marrow with Diffusion Weighted MRI and ADC Measurements

Turna, Önder; Aybar, Mustafa Devran; Tuzcu, Göksel; Karagöz, Yeşim; Kesmezacar, Ozgu; Turna, Isil Fazilet

doi:10.5152/imj.2014.94695

Cited by 5 publications

(6 citation statements)

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“…L4 was the most frequently involved vertebra, and the second most frequently involved vertebra was L1. These findings were akin to results documented by some previous studies [10,11].…”

Section: Discussionsupporting

confidence: 89%

“…In consonance with the literature, we found a significant variance amongst the ADC values of benign and malignant fractures with a lack of overlap [20][21][22]. In contrast to our observations, Turna et al documented that ADC values were not useful in distinguishing benign and malignant compression fractures, and there was an overlap of ADC values [10]. This disagreement might be linked to technical variations amongst studies as well as dissimilar stages of the diseases during the studies.…”

Section: Discussionsupporting

confidence: 84%

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Role of diffusion-weighted magnetic resonance imaging in the evaluation of vertebral bone marrow lesions

Kaur¹,

Thukral²,

Khanna³

et al. 2020

Pol J Radiol

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Purpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in differentiating vertebral marrow pathologies. To determine the sensitivity, specificity, and threshold apparent diffusion coefficient (ADC) values that can aid in the differentiation of malignant from benign bone marrow lesions. Material and methods: This observational study included 100 patients, who underwent MRI examination with a 1.5 Tesla scanner. The ADC values of normal and pathological vertebrae were estimated, and the threshold ADC values were computed by receiver operating characteristic (ROC) analysis. The results were correlated with histopathological diagnosis, clinical follow-up, and other investigations. Statistical analysis was done by employing unpaired two-tailed Student's t-test and the p-value of < 0.05 was deemed as statistically significant. Results: Vertebral bone marrow lesions had a male predominance and there was a predilection towards thoracic and lumbar vertebrae, with L4 being the commonest. Metastasis was the commonest lesion, followed by spondylodiscitis. The mean ADC value of benign pathologies was significantly greater than malignant pathologies (p < 0.05). The threshold value for the demarcation between benign and malignant pathologies was computed to be 1.21 × 10-3 mm 2 /s. DW imaging had sensitivity of 100%, specificity of 92.31%, positive predictive value of 87.5%, and negative predictive value of 100%. Conclusions: Vertebral marrow lesions can be differentiated as benign or malignant with good sensitivity and specificity with the help of DW-ADC maps.

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“…L4 was the most frequently involved vertebra, and the second most frequently involved vertebra was L1. These findings were akin to results documented by some previous studies [10,11].…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 84%

Role of diffusion-weighted magnetic resonance imaging in the evaluation of vertebral bone marrow lesions

Kaur¹,

Thukral²,

Khanna³

et al. 2020

Pol J Radiol

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“…tubercular lesions cause paradiscal involvement with end plate erosions, pyogenic infections predominantly involve facet joints, neoplastic marrow infil tration involve vertebral body marrow with or without pedicles and sparing of end plates. However these findings may overlap; thus, there is a need for newer techniques that can differentiate various vertebral marrow lesions [3].…”

Section: Introductionmentioning

confidence: 99%

The role of chemical shift magnetic resonance imaging in differentiating osteoporotic benign and malignant vertebral marrow lesions

Wadhawan

Kaur

et al. 2021

Pol J Radiol

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Purpose: To evaluate the usefulness of chemical shift imaging (CSI) in differentiating benign osteoporotic and malignant vertebral marrow lesions. Material and methods:Patients undergoing spinal magnetic resonance imaging (MRI) for back pain, which showed altered marrow signal intensity on conventional MRI sequences, were included in the study. Patients with acute traumatic vertebral fractures, infective spondylodiscitis, paravertebral collections, etc. were excluded. The patients underwent CSI. In-phase and opposed-phase images were taken to calculate the signal intensity ratio (SIR) of the abnormal vertebra. The SIR of the mean signal intensity measured on opposed-phase to mean signal intensity measured on in-phase images was measured and recorded. Results:The studied population included 30 patients, in whom 58 vertebrae were accessed, which included 38 dorsal, 18 lumbar, 1 sacral, and 1 cervical. Out of 58 vertebrae, 46 (79%) were malignant and 12 (20%) were benign. The mean CSI/SIR of malignant lesions was 0.96 and the mean SIR of benign lesions was 0.76. Conclusions:Conventional MRI sequences cannot always differentiate between benign and malignant lesions. So newer sequences like CSI have been developed. CSI SIR can be used as a new tool in differentiating benign osteoporotic and malignant vertebral marrow lesions.

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“…Sasaki(20) reported that the mean ADC value for bone marrow in normal cases were 0.97±0.17×10-3 mm 2 /s. In spondylodiscitis, restricted diffusion resulting in high signal intensity on DWI(21) . And, low ADC values were reported, similar to malignancy(21) .…”

mentioning

confidence: 99%

“…In spondylodiscitis, restricted diffusion resulting in high signal intensity on DWI(21) . And, low ADC values were reported, similar to malignancy(21) . A possible explanation for these reports is that hyper cellularity and the presence of macromolecules lower the diffusivity in inflammatory tissue.…”

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confidence: 99%

Assessment of Acute Osteomyelitis in the Mandible using Diffusion Weighted MR Imaging

Iwasaki

Muraoka

2020

Int J Oral-Med Sci

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Osteomyelitis of the mandible is most commonly caused by bacterial infections (1). In adults, osteomyelitis is usually an acute or chronic infection that develops follow to an open wound to the bone and around soft tissue. Acute osteomyelitis is caused by hematogenous spread or direct inoculation, and bacterial growth within the bone induces an acute suppurative response. Chronic osteomyelitis represents bone destruction and sequestrum formation. It is usually treated with medicine and surgical cleaning. Although, it can persist lengthening for years with frequent treatment failure or relapse (2, 3). Radiological imaging techniques play an essential part in the early diagnosis and followup of skeletal inflammatory conditions. The importance of radiology and imaging in the cases of osteomyelitis of the jaws is well documented in the past literature. It has also been reported that magnetic resonance imaging (MRI) is helpful in the diagnosis of mandibular osteomyelitis (4-9). DWI make use of the brownian motion of water protons in biological tissue. This movement mirrors the tissue unique diffusion capacity and can be used to characterize the organization. This movement brings results that dispersion phase of diffusion hyposensitized protons of water along the applied diffusion gradients and consecutively to a loss of signal on DWI. This signal loss is proportional to the diffusion intensity used and the mobility of water protons (10-12). DWI data based on MRI can be used for determination of quantitative diffusion values such as the ADC. ADC is a parameter for the amount of diffusion (proton of water) in the tissue. Many studies have reported evaluation to ADC values in musculoskeletal region such as normal bone marrow, osteoporosis, osteomyelitis, malignancy and trauma (13-15). However, there was a little attention to evaluate osteomyelitis of the mandible using DWI. The purpose of the present study was to investigate the mean of ADC values in the mandibular bone marrow with acute osteomyelitis and normal subject.

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Evaluation of Vertebral Bone Marrow with Diffusion Weighted MRI and ADC Measurements

Cited by 5 publications

References 0 publications

Role of diffusion-weighted magnetic resonance imaging in the evaluation of vertebral bone marrow lesions

Role of diffusion-weighted magnetic resonance imaging in the evaluation of vertebral bone marrow lesions

The role of chemical shift magnetic resonance imaging in differentiating osteoporotic benign and malignant vertebral marrow lesions

Assessment of Acute Osteomyelitis in the Mandible using Diffusion Weighted MR Imaging

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