Evaluation of tumor oxygenation by color duplex sonography: A new approach

Martino, Ercole F.N. Di; Gagel, Bernd; Schramm, Oliver; Maneschi, Payam; Westhofen, Martin

doi:10.1016/j.otohns.2005.01.033

Cited by 11 publications

(11 citation statements)

References 18 publications

(38 reference statements)

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“…Contrast-enhanced color duplex sonography (CDS) is a twodimensional ultrasound-based imaging modality that visualizes blood movement (i.e., blood flow) in tissue, typically using a contrast enhancer, to identify differential tissue perfusion to deduce areas of hypoxia. CDS can image vessels of very small diameter (0.1-0.2 mm), which is relevant to tumor flow as 10% of the tumor mass comprises such vessels (65). The correlation of CDS with tissue hypoxia using oxygensensitive polarographic electrodes was evaluated in H&NC patients from three different reports (65,94,95,241).…”

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confidence: 99%

“…CDS can image vessels of very small diameter (0.1-0.2 mm), which is relevant to tumor flow as 10% of the tumor mass comprises such vessels (65). The correlation of CDS with tissue hypoxia using oxygensensitive polarographic electrodes was evaluated in H&NC patients from three different reports (65,94,95,241). An inverse correlation was observed between tissue perfusion and hypoxic nodal volume when oxygen tensions were below 10 mmHg [r = -0.551; P = 0.021 (241); r = -0.71, P < 0.0001 (65); r = -0.788 (95); r = -0.730 (94)].…”

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confidence: 99%

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The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

Walsh

Lebedev

Aten³

et al. 2014

Antioxidants & Redox Signaling

352

317

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Tumor hypoxia is a well-established biological phenomenon that affects the curability of solid tumors, regardless of treatment modality. Especially for head and neck cancer patients, tumor hypoxia is linked to poor patient outcomes. Given the biological problems associated with tumor hypoxia, the goal for clinicians has been to identify moderately to severely hypoxic tumors for differential treatment strategies. The ''gold standard'' for detecting and characterizing of tumor hypoxia are the invasive polarographic electrodes. Several less invasive hypoxia assessment techniques have also shown promise for hypoxia assessment. The widespread incorporation of hypoxia information in clinical tumor assessment is severely impeded by several factors, including regulatory hurdles and unclear correlation with potential treatment decisions. There is now an acute need for approved diagnostic technologies for determining the hypoxia status of cancer lesions, as it would enable clinical development of personalized, hypoxia-based therapies, which will ultimately improve outcomes. A number of different techniques for assessing tumor hypoxia have evolved to replace polarographic pO 2 measurements for assessing tumor hypoxia. Several of these modalities, either individually or in combination with other imaging techniques, provide functional and physiological information of tumor hypoxia that can significantly improve the course of treatment. The assessment of tumor hypoxia will be valuable to radiation oncologists, surgeons, and biotechnology and pharmaceutical companies who are engaged in developing hypoxia-based therapies or treatment strategies. Antioxid. Redox Signal. 21, 1516-1554.

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confidence: 99%

mentioning

confidence: 99%

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

Walsh

Lebedev

Aten³

et al. 2014

Antioxidants & Redox Signaling

352

317

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“…tumour) located within the organ, the evaluation of perfusion of some fragments of parenchyma, or comparing perfusion of two chosen areas could bring additional important information. In these cases also the presence of data useful for objective digital evaluation could be indicated and helpful in the process of monitoring of, for example, the results of the some pharmacological treatment, especially since therapies involving impaired blood supply to tumour, and methods dedicated to tumor oxygenation are increasingly being used in medicine (6,10). Figure 7 presents the perfusion of the dogs` testicular tissue with a tumour.…”

Section: Discussionmentioning

confidence: 99%

Dynamic tissue perfusion measurement in the reproductive organs of the female and male dogs

Dzięcioł

Scholbach

Stańczyk

et al. 2014

Bulletin of the Veterinary Institute in Pulawy

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The aim of this study was to investigate the usefulness of new software Pixel Flux (PXFX) for clinical evaluation of tissue perfusion in the field of reproduction in dogs. The experiment was performed on six adult Beagle dogs. Different organs and tissues of the animals were examined with the MyLab25 Gold ultrasound system. Blood flow in the ovary, testicle, prostate, the ramification of the penile artery, and the network of blood vessels of the pampiniform plexus were examined with the use of colour coded Doppler technique, and obtained data was evaluated with the PXFX software. The more objective digital evaluation of data obtained with colour Doppler sonography through the application of dynamic tissue perfusion measurements provides new opportunities for diagnosis, as well as continuous monitoring of the function of the examined tissues and organs. The use of PXFX software is strongly indicated as a tool in small animal practice as an additional method for evaluation of tissue perfusion, especially in the cases when other methods like pulsed wave Doppler techniques are difficult to be performed.

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“…The length and the necessary insertion of the probe limit the size of the tumor or lymphatic node to be investigated. Altough pO 2 histography has been reported for even very small tumors, at least one author claims, that tissues < 20 mm cannot be evaluated [7] and the use of electrodes to measure pO 2 is limited to accessible areas which can tolerate multiple needle punctures. 18 F-labeled nitroimidazole drugs have been used to measure tumor tissue hypoxia by PET imaging.…”

Section: Discussionmentioning

confidence: 99%

Monitoring of Tumor Oxygenation Changes in Head-and-Neck Carcinoma Patients Breathing a Hyperoxic Hypercapnic Gas Mixture with a Noninvasive MRI Technique

et al. 2009

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: Measurement of oxygenation changes in head-and-neck tumor patients is feasible by the presented MRI technique. Tumor oxygenation and oxygenation changes were heterogeneous among the investigated patients. To the authors' knowledge, they are the first to describe a statistically significant difference in the heterogeneity of oxygenation changes induced by oxygen or 2% CO(2)/98% O(2) breathing using a noninvasive MRI technique.

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Evaluation of tumor oxygenation by color duplex sonography: A new approach

Abstract: The new approach is an alternative to pO2 histography and may play a future role in the planning of radiotherapy in the neck.

Cited by 11 publications

References 18 publications

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

Dynamic tissue perfusion measurement in the reproductive organs of the female and male dogs

Monitoring of Tumor Oxygenation Changes in Head-and-Neck Carcinoma Patients Breathing a Hyperoxic Hypercapnic Gas Mixture with a Noninvasive MRI Technique

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