Evaluation of traditional medicinal plant, Cissus setosa Roxb. (Vitaceae) for antiulcer property

Chinnamaruthu, Jayachitra; Senguttuvan, Jamuna; Ali, M. Ajmal; Paulsamy, S.; Al-Hemaid, Fahad M.A.

doi:10.1016/j.sjbs.2017.03.007

Cited by 15 publications

(10 citation statements)

References 19 publications

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“…Pyloric ligation is a surgical model used to determine anti-secretory activity. Ligating the pylorus causes intraluminal HCl accumulation, which aggressively damages the gastric mucosa [75]. In this study, gastric acid output was examined in all groups, but only the animals in the cimetidine group showed a significant reduction of gastric acid secretory rates and total acidity.…”

Section: Discussionmentioning

confidence: 92%

Anti-Inflammatory, Antinociceptive, Antipyretic, and Gastroprotective Effects of Eurycoma longifolia Jack Ethanolic Extract

Subhawa

Arpornchayanon

Jaijoy

et al. 2023

Life

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Tongkat ali (Eurycoma longifolia Jack) (ELJ) is a plant in the Simaroubaceae family. Its roots are used in traditional Thai medicine to treat inflammation, pain, and fever; however, the antiulcer abilities of its ethanolic extract have not been studied. This study examined the anti-inflammatory, antinociceptive, antipyretic, and gastroprotective effects of ethanolic ELJ extract in animal models and found that ELJ effectively reduced EPP-induced ear edema in a dose-dependent manner and that a high dose of ELJ inhibited carrageenan-induced hind paw edema formation. In cotton-pellet-induced granuloma formation, a high dose of ELJ suppressed the increases in wet granuloma weight but not dry or transudative weight. In the formalin-induced nociception study, ELJ had a significant dose-dependent inhibitory impact. Additionally, the study found that yeast-induced hyperthermia could be significantly reduced by antipyretic action at the highest dose of ELJ. In all the gastric ulcer models induced by chemical substances or physical activity, ELJ extracts at 150, 300, and 600 mg/kg also effectively prevented gastric ulcer formation. In the pyloric ligation model, however, the effects of ELJ extract on gastric volume, gastric pH, and total acidity were statistically insignificant. These findings support the current widespread use of Eurycoma longifolia Jack in traditional medicine, suggest the plant’s medicinal potential for development of phytomedicines with anti-inflammatory, antinociceptive, and antipyretic properties, and support its use in the treatment of gastric ulcers due to its gastroprotective properties.

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Section: Discussionmentioning

confidence: 92%

Anti-Inflammatory, Antinociceptive, Antipyretic, and Gastroprotective Effects of Eurycoma longifolia Jack Ethanolic Extract

Subhawa

Arpornchayanon

Jaijoy

et al. 2023

Life

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“…The genus Cissus comprises about 350 plant species distributed all over the world, mostly in tropical and subtropical regions. Some members of the genus are edible and serve as a source of both food and beverages while others are used as medicinal plants of great importance in treating a variety of both human and animal pathogenic infections [ 4 , 5 , 6 ]. Within Limpopo Province, South Africa, the bulbs are used in the treatment of various infections including cancer, sexually transmitted infections, and opportunistic infections associated with HIV-AIDS, and as a general well-being medicine [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Pharmacological Activity, and Comparison GC-ToF-MS Profiling of Extracts from Cissus cornifolia (Baker) Planch

Mongalo

Raletsena

Munyai

2023

Life

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Cissus cornifolia (Baker) Planch is traditionally used in South African traditional medicine (SATM) to treat a variety of human infections. The antimicrobial activity of extracts from C. cornifolia was investigated in vitro against a plethora of pathogenic microorganisms using the microdilution assay. The acetone extract exhibited a notable minimum inhibitory concentration (MIC) value of 0.10 mg/mL against Mycoplasma hominis and a further MIC of 0.20 mg/mL against Candida parapsilosis, Streptococcus agalactiae, Pseudomonas aeruginosa, and Enterococcus faecalis. In the antiproliferative assays, both the ethyl acetate and methanol extracts exhibited a potent inhibition of the MCF-7-21 cell line. In the anti-inflammatory assays, both the ethyl acetate and methanol extracts exhibited IC50 values of 15.59 and 15.78 µg/mL against Cyclooxygenase-2 (COX-2), respectively. Methanol extract further exhibited potent dual inhibition of both COX-2 and 15-LOX enzymes, hence, recommended to curb both related cancers, particularly breast cancer and inflammation-borne diseases. In the comparative gas chromatography time-of-flight mass spectrometry (GC/TOF-MS), the acetone, ethyl acetate, and methanol extract contained significantly prevalent amounts of compound 2-(2’,4’,4’,6’,6’,8’,8’-Heptamethyltetrasiloxan-2’-yloxy)-2,4,4,6,6,8,8,10,10-nonamethylcyclopentasiloxane with % area ranging from 15.714 to 39.225. The findings in the current work validates the use of the plant species in SATM in the treatment of cancer-like infections, opportunistic infections associated with HIV-AIDS. Furthermore, the in vivo studies and the mechanisms of action still need to be explored.

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“…It is generally accepted that it results from an imbalance between exogenous damaging agents, such as reactive oxygen species, alcohol consumption, cigarette smoking, Helicobacter pylori and the frequent use of nonsteroidal anti-inflammatory drugs (NSAIDs) and the endogenous protective mechanisms of the stomach (the mucosal barrier, mucus secretion, efflux of bicarbonate, increasing antioxidant levels, cell regeneration, prostaglandins, and nitric oxide among others) [7,8]. Despite the fact that many synthetic drugs are used in the clinic to manage gastric ulcer disease, including proton pump inhibitors, antacids and antihistaminic agents, these treatments are insufficient for complete ulcer healing, thus they are intimately linked to ulcer recurrence [9]. Additionally, the majority of treatments result in several adverse reactions, such as hypersensitivity, arrhythmia, hepatic injury, and Journal of Advanced Scientific Research, 2022; 13 (6): July-2022 hematopoietic changes, which limit their applications [10,11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Gastric Ulcer Activity of the Fruit Extracts of Terminalia Bellerica Roxb in Experimental Rodents

Mishra¹,

Gupta²,

Shrivastava³

et al. 2022

JASR

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Terminalia bellirica Roxb (T. bellirica, Combretaceae), known as Bahera or Beleric or bastard myrobalan is a large deciduous tree common on plains and lower hills in Southeast Asia, where it is also grown as an avenue tree. Glycoside, tannins, gallic acid, ellagic acid, ethyl galate, gallyl glucose, chebulanic acid are the main active phytoconstituents of medicinal importance. These phytoconstituents are responsible for many of the pharmacological roles. Different parts of the tree have various medicinal activities. In the present study, ethyl acetate and ethanolic extract of T. bellirica fruits, at the doses of 250 and 500mg/kg was evaluated for the anti-gastric ulcer activity using experimental gastric ulcer models induced by ethanol and aspirin. The phytochemical screening revealed the presence of triterpenoids, saponins, phenolic compounds, tannins, flavonoids, carbohydrate and glycosides. The parameters taken to assess anti-gastric ulcer activity were volume of gastric secretion, pH, free acidity, total acidity, ulcer index and histopathological studies of the stomach epithelium. The results indicate that the ethanolic and ethyl acetate extract of T. bellirica fruits produced a dosedependent reduction of the volume of gastric acid secretion, pH, free acidity, total acidity and ulcer index with respect to standard (Omeprazole 20mg/kg) used in the present study. The findings therefore indicate that ethyl acetate and ethanol extract possess anti-gastric ulcer activities in experimental animals induced by alcohol and aspirin, which might be due to presence of phenolic compound and flavonoids whose presence, was confirmed by phytochemical analysis. Therefore, this study validates its anti-gastric ulcer use in Indian folk medicine. Further investigations on isolation of specific phytochemicals and elucidating mechanisms of action are needed.

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Evaluation of traditional medicinal plant, Cissus setosa Roxb. (Vitaceae) for antiulcer property

Cited by 15 publications

References 19 publications

Anti-Inflammatory, Antinociceptive, Antipyretic, and Gastroprotective Effects of Eurycoma longifolia Jack Ethanolic Extract

Anti-Inflammatory, Antinociceptive, Antipyretic, and Gastroprotective Effects of Eurycoma longifolia Jack Ethanolic Extract

In Vitro Pharmacological Activity, and Comparison GC-ToF-MS Profiling of Extracts from Cissus cornifolia (Baker) Planch

Evaluation of Anti-Gastric Ulcer Activity of the Fruit Extracts of Terminalia Bellerica Roxb in Experimental Rodents

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