Evaluation of total phenolic content and antioxidant activity of different solvent extracts of leaf material of Spathodea campanulata P. Beauv. and investigation of their proliferation inhibition potential against EAC cell line

Sangeetha, S; Selvaraju, M.; Akshaya, S.; Vadivel, Vellingiri; Brindha, P.

doi:10.7324/japs.2016.60918

Cited by 8 publications

(9 citation statements)

References 4 publications

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“…The presence of tannins in the leaf extract could be the basis to the therapeutic use of the leaf as an antidote to animal poisoning and antioxidant. Onah [12] also revealed that methanol leaf extract of S. companulata showed antioxidant property, other researchers also reported that methanol(polar) extract has a high effectiveness as antioxidants, with these reports it is not surprising that the plant is used as an antioxidant [8,12,16,17,33,34]. The absence of flavonoids in the methanol extract is in line with report of Pulipati et al [11] that methanol leaf extract of S. companulata contained no flavonoids.…”

Section: Resultssupporting

confidence: 73%

“…The ethylacetate leaf extract contained flavonoids, tannins and glycosides. The presence of tannins and flavonoids showed the basis of ethnomedicinal use of the leaf as antioxidant since flavonoids and tannins were reported to have shown high antioxidant activities [16,40,41,42]. Alkaloids, saponins, flavonoids, glycosides were present in the ethyl acetate stem extract.…”

Section: Resultsmentioning

confidence: 99%

“…and investigation of their proliferation inhibition potential against EAC cell line revealed the presence of remarkable antioxidant and anticancer properties in the ethanolic extract of S. campanulata leaf. Ethanol (70%) could be the suitable solvent to recover the polyphenolic compounds with high antioxidant and anticancer potentials from S. campanulata leaf [16]. The result of In vitro free radical scavenging activity of leaves of Spathodea campanulata p. Beauv clearly indicated that leaves of Spathodea campanulata is an effective antioxidant and also showed superoxide and nitric oxide radicals scavenging activity [17].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Phytochemical and Anti-microbial Studies of Leaf, Stem, Root of Spathodea companulata

Anarado

Umedum

et al. 2020

AJACR

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Aim: To compare the phytochemicals and anti bacterial activities of leaf, stem and root extracts of Spathodea companulata. Methodology: The leaf, stem and root of Spathodea companulata were collected, washed, air-dried, ground and each extracted with water, methanol, ethyl acetate and n-hexane. The extracts were analysed for the presence of phytochemicals. Antimicrobial analysis was also carried out on the extracts. Results: Glycosides were present in all the extracts except stem aqueous extract. Steroids were found absent in most of the extracts except methanol stem and n-hexane root extracts. Saponins were found in methanol, aqueous and ethyl acetate extracts of the root and stem, and in methanol and aqueous leaf extracts. Alkaloids were present in methanol and aqueous extracts of the leaf and root, and in ethyl acetate and n- hexane extracts of the stem. Quantity of Alkaloids and tannins were higher in leaf, while flavonoids and glycosides were higher in the stem and the roots contained higher amount of saponins. The extraction solvent polarities played important role in the type of metabolites extracted. The stem extracts were found to be most active against the seven test organisms used. Conclusion: More work should be done on the isolation and identification of compounds responsible for some of the pharmacological effects of the plant parts and the subsequent development of the compounds in formulation of drugs.

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Section: Resultssupporting

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Phytochemical and Anti-microbial Studies of Leaf, Stem, Root of Spathodea companulata

Anarado

Umedum

et al. 2020

AJACR

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“…[ 14 ] Besides this, SRA has been reported to act as a chemotherapeutic and chemopreventive both in vitro and in vivo. [ 15,16 ]…”

Section: Introductionmentioning

confidence: 99%

“…[14] Besides this, SRA has been reported to act as a chemotherapeutic and chemopreventive both in vitro and in vivo. [15,16] The present work is done aiming to explore the anticancer effect of SRA in oral cancer SCC131 cell lines and to identify the me-…”

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confidence: 99%

Retracted: Syringic acid suppresses oral squamous cell carcinoma SCC131 cell proliferation via modulation of mitochondria‐mediated apoptosis signaling pathways

Velu

Vijayalakshmi

Vinothkumar

2020

J Biochem & Molecular Tox

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Apoptosis is an important process of cell death that controls the intrinsic and extrinsic pathways. Syringic acid (SRA)-a phenolic compound well-known in traditional Indian Ayurvedic medicine-has been reported to suppress cell proliferation of various cancer cells. Therefore, the current study aimed to investigate the inhibitory role of SRA on the proliferation of oral squamous cell carcinoma cells (SCC131) via reactive oxygen species (ROS) and induced mitochondria-mediated apoptosis. The study results showed that SRA (IC 50) was able to induce apoptosis in SCC131 cells via increased ROS generation, alteration of mitochondrial membrane potential, nuclear fragmentation, apoptotic morphological differences, and DNA injury. Moreover, SRA inhibited proliferative markers such as proliferating cell nuclear antigen and cyclin D1 protein expression in SCC131 cells. A diminished level of B-cell lymphoma 2 (Bcl-2) and augmented level of Bcl-2-associated X protein (Bax) were considered as markers of apoptotic cell death. In addition, SRA was able to decrease Bcl-2 and increase mutant p53, caspase-9, Bax, and caspase-3 expression in SCC131 cells. Taken together, SRA succeeded in inhibiting SCC131 cell growth through the ROS and mitochondria-mediated apoptosis in oral cancer cells. K E Y W O R D S apoptosis, mitochondrial membrane potential, oral squamous cell carcinoma, reactive oxygen species, syringic acid 1 | INTRODUCTION Oral squamous cell carcinomas (OSCCs) are malignancies that develop in the mouth, including the gums, tongue, skin lining, and/or the lips. Recently, tumor proliferation statistics reported 263 900 new cases and 128 000 deaths from oral cancer worldwide. [1] Although there are various inexpensive and effective saleable drugs in the market that can partially cure cancer, they are often associated with severe side effects mainly due to the continuous intake of the drug. [2] Nowadays, radiotherapy, chemotherapy, and surgery have become the most widely used techniques for cancer management. However, some challenges are still found in preventing toxicity and ensuring the effectiveness of chemotherapeutic drugs or radiotherapy in tumor cell therapy. [3] Recently, natural dietary agents similar to vegetables and fruits have become greatly accepted at the level of research and in practice for their capability to repress cancer and diminish the danger of cancer cell proliferation. [4] Chemoprevention using nontoxic agents might be a better approach for decreasing the occurrence of cancers. [5] Developing novel phytochemicals which are cost-effective, nontoxic, and have physiological bioavailability represents another promising approach that could be targeted by organizations facing cancer. [6] Apoptosis is programmed cell death that is implicated in many human cancers. The characteristic morphological alterations observed include mitochondrial depolarization, cellular destruction, cell reduction, extensive plasma membrane, and separation of cell fragments

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Antioxidant capacity and phytochemical characterization of Spathodea campanulata growing in different climatic zones in Brazil

Santos

Minatel

Lima

et al. 2020

Biocatalysis and Agricultural Biotechnology

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Evaluation of total phenolic content and antioxidant activity of different solvent extracts of leaf material of Spathodea campanulata P. Beauv. and investigation of their proliferation inhibition potential against EAC cell line

Cited by 8 publications

References 4 publications

Comparative Phytochemical and Anti-microbial Studies of Leaf, Stem, Root of Spathodea companulata

Comparative Phytochemical and Anti-microbial Studies of Leaf, Stem, Root of Spathodea companulata

Retracted: Syringic acid suppresses oral squamous cell carcinoma SCC131 cell proliferation via modulation of mitochondria‐mediated apoptosis signaling pathways

Antioxidant capacity and phytochemical characterization of Spathodea campanulata growing in different climatic zones in Brazil

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