Antioxidant capacity and phytochemical characterization of Spathodea campanulata growing in different climatic zones in Brazil

Santos, Valter Henrique Marinho dos; Minatel, Igor Otávio; Lima, G. P. P.; Silva, Regildo M.G.; Chen, Chung-Yen O.

doi:10.1016/j.bcab.2020.101536

Cited by 8 publications

(10 citation statements)

References 41 publications

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“…Apparently, the leaf extracts contained more total bioactive compounds than the stem bark extracts. Similarly, in a recent study by Santos, Minatel, Lima, Silva, and Chen [ 13 ], the leaf extracts of S. campunalata collected from Brazil had higher concentrations of total phenolics than flower and nectar extracts. In another study [ 24 ], total phenolic content was higher in the ethanol extract of S. campanulata leaves compared to chloroform and ethyl acetate extracts.…”

Section: Resultsmentioning

confidence: 68%

“…The presence of several bioactive compounds has been reported, including flavonoids, phenolic acids, and iridoids [ 2 , 3 , 5 , 6 , 7 , 8 , 9 ]. With regard to its pharmacological properties, a wide range of biological properties, from antioxidant to antiviral, has been declared [ 2 , 3 , 5 , 10 , 11 , 12 , 13 , 14 , 15 ]. Interestingly, the aqueous leaf extract of S. campanulata was found to exert potent larvicidal and pupicidal properties and induce morphological deformities in Aedes aegypti , a vector of dangerous pathogenic viruses, including chikungunya, dengue, Mayaro, yellow fever, and Zika viruses [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

et al. 2022

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Spathodea campanulata is an important medicinal plant with traditional uses in the tropical zone. In the current work, we aimed to determine the chemical profiles and biological effects of extracts (methanolic and infusion (water)) from the leaves and stem bark of S. campanulata. The chemical components of the tested extracts were identified using LC-ESI-QTOF-MS. Biological effects were tested in terms of antioxidant (radical scavenging, reducing power, and metal chelating), enzyme inhibitory (cholinesterase, amylase, glucosidase, and tyrosinase), antineoplastic, and antiviral activities. Fifty-seven components were identified in the tested extracts, including iridoids, flavonoids, and phenolic acids as the main constituents. In general, the leaves-MeOH extract was the most active in the antioxidant assays (DPPH, ABTS, CUPRAC, FRAP, metal chelating, and phosphomolybdenum). Antineoplastic effects were tested in normal (VERO cell line) and cancer cell lines (FaDu, HeLa, and RKO). The leaf infusion, as well as the extracts obtained from stem bark, showed antineoplastic activity (CC50 119.03–222.07 µg/mL). Antiviral effects were tested against HHV-1 and CVB3, and the leaf methanolic extract (500 µg/mL) exerted antiviral activity towards HHV-1, inhibiting the viral-induced cytopathic effect and reducing the viral infectious titre by 5.11 log and viral load by 1.45 log. In addition, molecular docking was performed to understand the interactions between selected chemical components and viral targets (HSV-1 DNA polymerase, HSV-1 protease, and HSV-1 thymidine kinase). The results presented suggest that S. campanulata may be a bright spot in moving from natural sources to industrial applications, including novel drugs, cosmeceuticals, and nutraceuticals.

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Section: Resultsmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

et al. 2022

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“…Ait Lahcen et al evaluated the antioxidant capacity of a Moroccan Cistus creticus leaf extract by measuring DPPH ⋅ and FRAP free radical scavenging abilities [46]. Santos et al used assays to measure oxygen radical absorbance capacity, ferric reducing antioxidant power, and DPPH radical scavenging capacity to evaluate the antioxidant capacity of Spathodea campanulata [47]. Wang et al evaluated the protective effects of araloside C against H 2 O 2 -induced oxidative stress by assessing the release of LDH, mitochondrial function, and bioenergetics in H9c2 cardiomyocytes [48].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H₂O₂‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Tian

Zhang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Araloside A is a pentacyclic triterpenoid saponin, and L-ascorbic acid is a globally recognized antioxidant. In this study, coadministered araloside A and L-ascorbic acid were found to have a strong synergistic antioxidant effect, and correlations between cellular antioxidant indexes and free radical scavenging ability were found. Individual and combined pretreatment with araloside A and L-ascorbic acid increased both cell viability and antioxidant enzyme activity and inhibited the release of lactate dehydrogenase (LDH); the accumulation of malondialdehyde (MDA), lipid peroxidation (LPO) products, and H2O2; and the production of intracellular reactive oxygen species (ROS), protein carbonyls, and 8-hydroxy-2-deoxy guanosine (8-OHdG). Free radical scavenging ability was positively correlated with superoxide dismutase (SOD) and catalase (CAT) activity, the glutathione (GSH)/oxidized glutathione (GSSG) ratio, and total antioxidant capacity (T-AOC). Our study is the first investigation of araloside A and L-ascorbic acid coadministration for the treatment of diseases caused by oxidative stress. The synergistic antioxidant effects of araloside A and L-ascorbic acid support their potential as functional food ingredients for the elimination of oxidative stress-induced adverse reactions.

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“…and experimental differences (concentration, expressed unit, etc.) [29,30]. In addition, most scientists have recently given up the use of the Folin-Ciocalteu assay because not only phenolics but also other phytochemicals could play a reducing role in the assay [31].…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

et al. 2021

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Seseli L. is one of the largest genera of the Apiaceae family widely known for their traditional uses as herbal remedies. In the present study, the methanolic and water extracts of two Seseli species, S. gummiferum and S. transcaucasicum were evaluated for their bioactive contents and biological activities. The total phenolic and flavonoid contents in the extracts ranged from 19.09 to 24.33 mg GAE/g and from 0.45 to10.09 mg RE/g, respectively. Moreover, while narcissin was detected as the most abundant component in the methanolic extract of S. transcaucasicum (261.40 µg/g), chlorogenic acid was identified as the major component in all the other extracts, although a high amount was also present in the methanolic S. transcaucasicum extract (107.48–243.12 µg/g). The total antioxidant capacity was also determined by the phosphomolybdenum assay (0.66–1.18 mM TE/g). Other antioxidant assays such as the radical scavenging assays (DPPH: 5.51–11.45 mg TE/g; ABTS: 43.46–51.91 mg TE/g), reducing assays (CUPRAC: 41.67–53.20 mg TE/g; FRAP: 31.26–34.14 mg TE/g), as well as the metal chelating activity assay (14.38–38.57 mg EDTAE/g) were conducted. All the extracts showed inhibitory potential against the enzyme’s amylase (0.12–0.78 mM ACAE/g), acetyl- and butyryl-cholinesterase (0.15–9.71 mg GALAE/g), while only the methanolic extracts acted as inhibitors of tyrosinase (107.15 and 109.37 mg KAE/g) and only the water extract of S. gummiferum displayed anti-glucosidase activity (0.13 mM ACAE/g). Interestingly, the methanolic extracts of both Seseli species showed lower cytotoxicity towards HaCaT cells (IC50: >500 µg/mL), compared to the water extracts (IC50: 267.8 and 321.41 µg/mL). Besides, only the methanolic extracts showed a slight wound healing effect (28.21 and 31.23%). All extracts showed antibacterial action against Staphylococcus lugdunensis (minimum inhibitory and bactericidal concentrations: 0.025–2 mg/mL). S. gummiferum methanolic extract, which exhibited the highest antibacterial potency was found to inhibit adhesion and invasion of S. lugdunensis to HaCaT cells as well. Taken together, this study demonstrated the two Seseli species to harbour interesting bioactive components, in particular polyphenolics and to exhibit several biological properties that could be further investigated for their potential exploitation as healing agents as supported by various traditional medicinal uses.

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Antioxidant capacity and phytochemical characterization of Spathodea campanulata growing in different climatic zones in Brazil

Cited by 8 publications

References 41 publications

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H₂O₂‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

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Antioxidant capacity and phytochemical characterization of Spathodea campanulata growing in different climatic zones in Brazil

Cited by 8 publications

References 41 publications

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H2O2‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

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Synergistic Antioxidant Effects of Araloside A and L‐Ascorbic Acid on H₂O₂‐Induced HEK293 Cells: Regulation of Cellular Antioxidant Status