Evaluation of Topical Gel Bases Formulated with Various Essential Oils for Antibacterial Activity against Methicillin- Resistant &lt;i&gt;Staphylococcus Aureus&lt;/i&gt;

Shukr, Marwa H; Metwally, Ghada Farouk

doi:10.4314/tjpr.v12i6.3

Cited by 52 publications

(45 citation statements)

References 13 publications

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“…It is the term expressed to denote the extent of area to which gel readily spreads on application. Therapeutic efficacy of a gel formulation also depends on its spreading value [22]. Additionally, spreadability is very important as it shows the behavior of the gel when it comes out from the tube [39].…”

Section: Resultsmentioning

confidence: 99%

“…They found that Carbopol (C934) gel-based formulations exhibited better antibacterial activity against P. aeruginosa , S. aureus , and E. coli in comparison to other dermatological base formulations, indicating better activity of the drug. Moreover, it was reported that C934 based gel proved to be the polymer of choice since it showed the highest antimicrobial activity when compared to other gel-based formulations [22, 39]. For the above reasons, F13 was the formula of choice to investigate its efficacy in wound treatment.…”

Section: Resultsmentioning

confidence: 99%

“…Spreadability (g·cm/sec) is expressed in terms of time taken in seconds by two slides to slip off from the gel placed between them, under certain load [21]. The standardized weight tied on the upper plate was 20 g and length of the glass slide was 7.5 cm [22]. Spreadability was calculated by using the following formula:

\begin{matrix} T1 \\ S p r e a d a b i l i t y = \frac{(W e i g h t \times L e n g t h)}{T i m e} . \end{matrix}

According to the above equation, it is clear that the lesser the time taken for separation of the two slides, the better its spreadability.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity andIn VivoEvaluation

Zakaria

Afifi

Elkhodairy

2016

BioMed Research International

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In an attempt to reach better treatment of skin infections, gel formulations containing Cefotaxime (CTX) were prepared. The gel was formulated using Carbopol 934 (C934), Hydroxypropyl Methylcellulose 4000 (HPMC 4000), Carboxymethylcellulose Sodium (Na CMC), Pectin (PEC), Xanthan Gum (XG), or Guar Gum (GG). Thirteen different formulas were prepared and characterized physically in terms of color, syneresis, spreadability, pH, drug content, and rheological properties. Drug-excipients compatibility studies were confirmed by FTIR and then in vitro drug release study was conducted. In vitro and in vivo antibacterial activities of CTX were studied against wound pathogens such as, Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Pseudomonas aeruginosa (P. aeruginosa), using either pure drug or Fucidin® cream as control. F13 provides better spreadability compared to F1 (XG) or F11 (HPMC). Moreover, the release of the drug from hydrogel F13 containing C934 was slower and sustained for 8 h. Stability study revealed that, upon storage, there were no significant changes in pH, drug content, and viscosity of the gels. Also, F13 showed the larger inhibition zone and highest antibacterial activity among other formulations. Histological analysis demonstrated that after single treatment with F13 gel formulation, a noticeable reduction in microbial bioburden occurred in case of both Gram positive and Gram negative bacterial isolates.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

\begin{matrix} T1 \\ S p r e a d a b i l i t y = \frac{(W e i g h t \times L e n g t h)}{T i m e} . \end{matrix}

According to the above equation, it is clear that the lesser the time taken for separation of the two slides, the better its spreadability.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity andIn VivoEvaluation

Zakaria

Afifi

Elkhodairy

2016

BioMed Research International

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“…The viscosity of the formulas decreased with increasing enhancer concentration. It was between 17850 cP to 15935 cP (table 1) [20]. …”

Section: General Characteristics Of Formulated Gelsmentioning

confidence: 99%

The Enhancement Effect of Castor Oil on the Permeability of Flurbiprofen as Transdermal Gel

2018

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Objective: The object of this study was to improve flurbiprofen permeability transdermally using castor oil as penetration enhancer. Methods:Castor oil with different concentrations (1%, 2%, 3%, 4%, and 5%) was used in this study as a natural enhancer to improve flurbiprofen permeation transdermally as a gel. The formulated gel of the drug was evaluated for several physicochemical characteristics. The in vitro release and permeability studies for the drug were performed using Franz cell diffusion apparatus across the synthetic membrane. Korsmeyer Pappas kinetic model was used to study the release mechanism of flurbiprofen from the gel. Results:The results demonstrated that castor oil was safe with no skin irritation and the formulas were stable over time. Castor oil was significantly effective in increasing the percent of flurbiprofen permeability from 46%±2.9 for the gel without enhancer to 95%±2 for the gel with 5% castor oil and increasing its penetration is directly related to the oil concentration. Two mechanisms for the drug release from the gel were involved, which are non-Fickian (anomalous) and super case II transport. Conclusion:Flurbiprofen gel was prepared and evaluated successfully for an in vitro parameters with a good permeation across a synthetic membrane. The results demonstrated that castor oil had an effective enhancement for permeation of flurbiprofen.

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“…PVA solution exhibited pseudo-plastic flow as evidenced by Farrow's constant (>1). 47 The Farrow's constant values for 2, 4, and 8% w/v PVA and PVA-Ag solution were found to be 5. 26 It has been found that when PVA alone (without AgNPs) was used for the measurement, viscosity of PVA is less than that of PVA/Ag; this could be due to the presence of free hydroxyl group and lack of the interaction among the OH groups and Ag nanoparticles.…”

mentioning

confidence: 99%

Design and in vitro investigation of nanocomposite hydrogel based in situ spray dressing for chronic wounds and synthesis of silver nanoparticles using green chemistry

Kumar

Jaiswal

2015

J of Applied Polymer Sci

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An innovative concept of spontaneous film dressing has been designed as sprayed hydrogel dressings (SHD) using a blend of polyvinyl alcohol (PVA) and sodium alginate (SA) as synthetic and natural polymeric components and, were crosslinked with boric acid and calcium chloride, respectively. Silver nanoparticles (AgNPs) are synthesized by green chemistry using Ficus benghalensis extract (FB) and were characterized by SEM and zeta sizer. FTIR spectra show polymeric interaction with AgNP s , while SEM images show outer surface of the SHD film. Equilibrium swelling and degradation in aqueous media (distilled water and buffers) are found to be dependent upon PVA/SA ratio. Polymeric combination exhibit pseudoplastic behavior with Farrow's constant >1. Uniformly distributed AgNPs (particle size 27.55 6 2.01 nm), high water retention (13 fold), and biodegradable (5 days) nature of dressing along with sustained release profile of both AgNPs and extract with concentration-dependent antimicrobial activity have been observed for 24 h. Self shaped, biodegradable, aseptic, prolong anti-oxidative, non-hemolytic, blood compatible, and hemostatic properties of SHD film appears as promising dressing for superficial wounds.

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Evaluation of Topical Gel Bases Formulated with Various Essential Oils for Antibacterial Activity against Methicillin- Resistant <i>Staphylococcus Aureus</i>

Cited by 52 publications

References 13 publications

Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity andIn VivoEvaluation

Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity andIn VivoEvaluation

The Enhancement Effect of Castor Oil on the Permeability of Flurbiprofen as Transdermal Gel

Design and in vitro investigation of nanocomposite hydrogel based in situ spray dressing for chronic wounds and synthesis of silver nanoparticles using green chemistry

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