Evaluation of Therapeutic Efficacy of Antioxidants in Psoriatic Cases

Madhulatha, M; Vijayabhaskar, M.

doi:10.5005/jp-journals-10054-0077

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Madhulatha and Vijayabhaskar (2019) 15 reported antioxidant supplementation therapy along with conventional therapy for 8 weeks, in psoriatic patients, resulted in a significant decrease in mean serum levels of MDA, while the total antioxidant levels increased significantly. Relhan et al,2002 16 in their study observed the same results.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of antioxidants in the management of psoriasis: A case control study

Mohammod Abu Hena Chowdhury,

Afroza Jesmin,

Samiul Huq

et al. 2024

World J. Adv. Res. Rev.

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Introduction: Psoriasis is a chronic, immune-mediated inflammatory dermatosis. The pathophysiology of the disease is still incompletely elucidated and multiple factors are said to be involved in its initiation and perpetuation, e.g., stressors, genetic factors, environmental factors. In the last decade, a new theory is trying to explain the pathophysiology of this disease by looking at the role played by oxidative stress and chronic inflammation in the initiation of keratinocyte proliferation and differentiation. Keeping in consideration the increased oxidative stress in the patients of psoriasis, the anti-oxidant drugs can form an important part of the therapeutic ladder of psoriasis. Materials and Methods: The aim of this study was to measure the possible role of oxidative stress in psoriasis patient by measuring SOD level and comparing it with normal individuals and administer antioxidants supplements to the patients group to see the efficacy. It was a Case- Control study (1st part) and Clinical Trial without control group (2nd part). The study was carried out in Psoriasis awareness Club from June 2023 to December 2023. Purposive sampling done who fulfill the inclusion & exclusion criteria. 23 patients with psoriasis and 23 age and sex matched control subjects were recruited for this study. Clinical severity of the disease was determined by PASI score. All patients and control subjects were examined for plasma SOD level. 23 psoriatic patients were given antioxidant therapy in the form of once daily tablet for 30 days. PASI score, DLQI and SOD (Superoxide dismutase) level were measured before therapy (day 0) and after therapy (day 30) in patients group. Statistical analysis and Results: Data were expressed as mean ± standard deviation (SD) for quantitative variables and numbers. For comparison of two means (t test) and (ANOVA "F") test were used for several means. Chi-square (χ2 ) or fisher exact test were used when appropriate, (P<0.05) was considered statistically significant. The mean age of the patients and control subjects were 37.64 (±5.89) and 33.6 (11.02) years, respectively. The mean duration of the disease was 12.43 (±8) years. No significant difference was observed between SOD level of psoriatic patients & controls. No significant correlations of SOD level with severity of psoriasis and duration of disease were found. We observed no statistically significant difference in PASI and DLQI scores before and after antioxidant therapy but there was significant increase in the level of SOD after treatment. Conclusion: It is indisputable that antioxidant supplementation can reduce the overall morbidity, enhance the prognosis of psoriasis. Notably, in most cases, antioxidants alone are not able to induce significant clinical changes in the aspect and/or course of the disease, except perhaps in mild forms. They must be used in conjunction with standard pharmacological treatments to achieve measurable results.

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Section: Discussionmentioning

confidence: 99%

Efficacy of antioxidants in the management of psoriasis: A case control study

Mohammod Abu Hena Chowdhury,

Afroza Jesmin,

Samiul Huq

et al. 2024

World J. Adv. Res. Rev.

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“…Studies conducted on psoriasis patients corroborated the effectiveness of exogenous antioxidants as a supplementary therapy in the course of pharmacological psoriasis treatment. Madhulatha and Vijayabhaskar [ 157 ] demonstrated a significant decrease of MDA and increased total antioxidative capacity (TAC) in the blood serum of patients receiving pharmacological treatment already after eight weeks of therapy using a mixture of antioxidants (30 mg β-carotene + 27.5 mg zinc sulphate monohydrate + 0.2 mg monohydrated selenium dioxide + 2 mg manganese + 1 mg copper). In a study by Kharaeva at al.…”

Section: Clinical Studiesmentioning

confidence: 99%

Importance of Redox Equilibrium in the Pathogenesis of Psoriasis—Impact of Antioxidant-Rich Diet

2020

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Psoriasis is a common, chronic, hyperproliferative, inflammatory skin disease occurring in most ethnic groups in the world. The disease is hereditary but the process of its inheritance is complex and still not fully understood. At the same time, it has been observed that psoriatic lesions may be triggered by certain prooxidative external factors: using narcotics, smoking, drinking alcohol, physical and mental stress, as well as bacterial infections and injury. Since the main physiological marker of psoriasis relates to disorders in the organism’s antioxidative system, it is necessary to develop a well-balanced combination of pharmaceuticals and dietary antioxidants to facilitate the effective treatment and/or prevention of the disease. The dietary sources of antioxidants must be adequate for chronic use regardless of the patient’s age and be easily available, e.g., as ingredients of regular food or dietary supplements. Diet manipulation is a promising therapeutic approach in the context of modulating the incidence of chronic diseases. Another potentially viable method entails the use of nutrigenomics, which guarantees a multiaspectual approach to the problem, including, in particular, analyses of the genetic profiles of psoriasis patients with the view to more accurately targeting key problems. The present paper pertains to the significance of redox equilibrium in the context of psoriasis. Based on information published in worldwide literature over the last decade, the impact of dietary exogenous antioxidants on the course of this chronic disease was analysed.

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Evaluation of Therapeutic Efficacy of Antioxidants in Psoriatic Cases

Cited by 2 publications

References 19 publications

Efficacy of antioxidants in the management of psoriasis: A case control study

Efficacy of antioxidants in the management of psoriasis: A case control study

Importance of Redox Equilibrium in the Pathogenesis of Psoriasis—Impact of Antioxidant-Rich Diet

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