Importance of Redox Equilibrium in the Pathogenesis of Psoriasis—Impact of Antioxidant-Rich Diet

Winiarska-Mieczan, Anna; Mieczan, Tomasz; Wójcik, Grzegorz

doi:10.3390/nu12061841

Cited by 18 publications

(18 citation statements)

References 158 publications

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“…Maintaining a correct diet by eliminating some foods and including others can limit the release of such antibodies if the comorbidity is confirmed, thus contributing to the overall improvement of the diabetes patient's health. The positive effects of tea consumption on the health of patients with various autoimmune diseases have been confirmed in numerous studies [5,65,149,174,175].…”

Section: Immunomodulatory Activitymentioning

confidence: 80%

“…Mitochondria are the main source of oxidative stress in diabetes [49,64]. During oxidative metabolism, mitochondria reduce oxygen to H 2 O, while any excess oxygen is converted into reactive oxygen species O•, and then into peroxynitrite ONOO−, hydroxy radical OH•, and hydrogen peroxide H 2 O 2 [46,48,65]. Additionally, the lipids of mitochondrial membranes are susceptible to damage.…”

Section: Oxidative Stressmentioning

confidence: 99%

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Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

2021

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The physiological markers of autoimmune diabetes include functional disorders of the antioxidative system as well as progressing inflammation and the presence of autoantibodies. Even though people with type 1 diabetes show genetic predispositions facilitating the onset of the disease, it is believed that dietary factors can stimulate the initiation and progression of the disease. This paper analyses the possibility of using tea as an element of diet therapy in the treatment of type 1 diabetes. Based on information available in literature covering the last 10 years, the impact of regular tea consumption or diet supplements containing tea polyphenols on the oxidative status as well as inflammatory and autoimmune response of the organism was analyzed. Studies conducted on laboratory animals, human patients, and in vitro revealed positive effects of the consumption of tea or polyphenols isolated therefrom on the diabetic body. Few reports available in the literature pertain to the impact of tea on organisms affected by type 1 diabetes as most (over 85%) have focused on cases of type 2 diabetes. It has been concluded that by introducing tea into the diet, it is possible to alleviate some of the consequences of oxidative stress and inflammation, thus limiting their destructive impact on the patients’ organisms, consequently improving their quality of life, regardless of the type of diabetes. Furthermore, elimination of inflammation should reduce the incidence of immune response. One should consider more widespread promotion of tea consumption by individuals genetically predisposed to diabetes, especially considering the drink’s low price, easy availability, overall benefits to human health, and above all, the fact that it can be safely used over extended periods of time, regardless of the patient’s age.

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Section: Immunomodulatory Activitymentioning

confidence: 80%

Section: Oxidative Stressmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

2021

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“…EGCG belongs to the flavonoids. Its high concentration is found in green tea, quercetin, theaflavin, and thearubigin, present in black tea, as well as tannic acid [ 139 ]. It has been reported that EGCG possesses many benefits.…”

Section: Substances Of Natural Origin—plants and Phytochemicals With ...mentioning

confidence: 99%

Promising Strategies in Plant-Derived Treatments of Psoriasis-Update of In Vitro, In Vivo, and Clinical Trials Studies

et al. 2022

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Psoriasis is a common, chronic systemic inflammatory disease affecting 125 million people worldwide. It is associated with several important conditions, including psoriatic arthritis, cardiometabolic syndrome, and depression, leading to a significant reduction in patients’ quality of life. Current treatments only reduce symptoms, not cure. This review discusses the mechanisms involved in the initiation and development of the disease, the role of oxidative stress in this autoimmune disease, as well as potential therapeutic options with substances of natural origin. The main aim of the study is intended to offer a review of the literature to present plants and phytochemicals that can represent potential remedies in the fight against psoriasis. We identified many in vitro, in vivo, and clinical trials studies that evaluated the relationship between chosen natural substances and immune system response in the course of psoriasis. We sought to find articles about the efficacy of potential natural-derived drugs in controlling symptoms and their ability to maintain long-term disease inactivity without side effects, and the result of our work is a review, which highlights the effectiveness of plant-derived drugs in controlling the inflammatory burden on psoriatic patients by decreasing the oxidative stress conditions.

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“…Reports have shown that a diet rich in vitamin C, β-carotene, and flavonoids, which includes green vegetables, carrots, tomatoes, and fruit, helps improve skin lesions [ 6 , 34 ]. Therefore, persons with psoriasis should increase the intake of fresh fruit and vegetables as well as include polyphenol-rich products such as tea, coffee, herbs, and spices in their diet [ 47 ].…”

Section: The Importance Of Antioxidantsmentioning

confidence: 99%

Nutritional Therapy in Persons Suffering from Psoriasis

et al. 2021

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Psoriasis is a chronic inflammatory skin disease. Immunological, genetic, and environmental factors, including diet, play a part in the pathogenesis of psoriasis. Metabolic syndrome or its components are frequent co-morbidities in persons with psoriasis. A change of eating habits can improve the quality of life of patients by relieving skin lesions and by reducing the risk of other diseases. A low-energy diet is recommended for patients with excess body weight. Persons suffering from psoriasis should limit the intake of saturated fatty acids and replace them with polyunsaturated fatty acids from the omega-3 family, which have an anti-inflammatory effect. In diet therapy for persons with psoriasis, the introduction of antioxidants such as vitamin A, vitamin C, vitamin E, carotenoids, flavonoids, and selenium is extremely important. Vitamin D supplementation is also recommended. Some authors suggest that alternative diets have a positive effect on the course of psoriasis. These diets include: a gluten-free diet, a vegetarian diet, and a Mediterranean diet. Diet therapy for patients with psoriasis should also be tailored to pharmacological treatment. For instance, folic acid supplementation is introduced in persons taking methotrexate. The purpose of this paper is to discuss in detail the nutritional recommendations for persons with psoriasis.

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Importance of Redox Equilibrium in the Pathogenesis of Psoriasis—Impact of Antioxidant-Rich Diet

Cited by 18 publications

References 158 publications

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

Promising Strategies in Plant-Derived Treatments of Psoriasis-Update of In Vitro, In Vivo, and Clinical Trials Studies

Nutritional Therapy in Persons Suffering from Psoriasis

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