Oxidative stress is likely to be involved in the development of complications due to haemodialysis. Though there is evidence for production of oxygen free radicals during haemodialysis, reports on net oxidative imbalance due to a single dialysis session are conflicting. Hence, a time-course analysis of changes in lipid peroxides (LPO) along with antioxidant enzymes and vitamins was carried out. Hourly changes in LPO and antioxidants were studied during a first-use cuprophan membrane and acetate dialysis in 20 patients on regular haemodialysis treatment. Data were corrected for haemoconcentration and standardised to measure the rate of change before statistical evaluation using analysis of variance for repeated measures. The results of the study showed a net oxidative stress due to a single dialysis session in the form of increased plasma and erythrocyte lipid peroxidation, decrease in plasma vitamin E, slight increase in plasma superoxide dismutase and erythrocyte glutathione peroxidase and no change in plasma glutathione peroxidase. erythrocyte superoxide dismutase and plasma vitamin A levels. The oxygen radical production was found to be maximum in the first hour of dialysis.
Introduction: Psoriasis is one of the debilitating diseases of the skin of chronic inflammatory origin. Oxidative stress is considered as the culprit for the oxidant and antioxidant imbalance, resulting in psoriasis. Objectives: This study was undertaken to know the effects of oxidative stress in the origin and development of psoriasis and to evaluate the beneficial effect of antioxidant therapy in psoriatic patients along with conventional treatment. Materials and methods: Thirty-three patients of age group 20-60 years with chronic plaque psoriasis, from the outpatient department of Dermatology, Mamata General Hospital, Khammam, Telangana, India were considered for the study. Patients with a duration of disease from 6 months to 2 years were enrolled for the study. The severity of psoriasis was determined using the psoriasis area severity index (PASI). Informed consent from the patients and institutional ethical committee clearance were taken. Antioxidant therapy was given for 8 weeks along with conventional therapy. Malondialdehyde (MDA) and total antioxidant capacity were measured and compared before and after the therapy. Results: After antioxidant therapy for 8 weeks, it was observed that there was a significant decrease in mean serum levels of MDA and increased levels of total antioxidant capacity (TAC). Conclusion:The results revealed that antioxidant therapy along with conventional therapy of psoriasis is more beneficial in the treatment of psoriatic cases.
The present study was conducted to know the relation of myocardial infarction with its risk factors and to prevent future cardiac events. MATERIAL AND METHODS: 60 cases of myocardial infarction were selected along with 60 age and sex matched healthy controls. Body mass index, blood pressure, fasting plasma glucose and lipid profile were measured. STATISTICAL ANALYSIS: All values were expressed as Mean +/-SD. The results obtained were analyzed statistically using the unpaired student 't' test to evaluate the significance of difference between the mean values. RESULTS: The values of body mass index, fasting plasma glucose, systolic blood pressure, diastolic blood pressure, total cholesterol, total triglycerides and low density lipoprotein cholesterol were increased whereas high density lipoprotein cholesterol was decreased in the patients of myocardial infarction. CONCLUSION: On the basis of our results, it may be concluded that risk factors increase incidence of myocardial infarction.
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