Evaluation of the Role of Intercellular Adhesion Molecule 1 in a Rodent Model of Chronic Venous Hypertension

Pathogenesis of primary chronic venous disease: Insights from animal models of venous hypertension

“…80,81 Research using the large vein ligation model of venous hypertension in the rat has shown that a relatively modest elevation of venous pressure can provoke leukocyte migration leading to elevated tissue leukocyte levels that are detectable within approximately 2 hours of ligation and which persist for at least a week with chronic pressure elevation. 33,34 Leukocyte accumulation was largely prevented by prior injection of an anti-ICAM-1 monoclonal antibody, 35 confirming the key role of ICAM-1 in leukocyte adherence and migration in skin tissue as well as in the walls and valves of large veins. Interestingly, endothelial expression of ICAM-1 was not increased after 14 days of venous hypertension.…”

“…Control: unpressurized, contralateral valves; vehicle, pressurized valves treated with vehicle alone; MPFF 50 and MPFF 100: pressurized valves treated with MPFF 50 and 100 mg/kg/day. From Takase et al 29 MPO activity in acute rats, from 19.8 Ϯ1.54 units to 6.71 Ϯ 2.46 units (P Ͻ.001).There was no difference in endothelial expression of ICAM-1 between normotensive and hypertensive limbs 2 weeks after ligation 35. …”

“…Another rodent model, in which venous hypertension was produced by ligation of several large veins, [33][34][35] has been used to investigate the link between venous hypertension and the skin changes that are important manifestations of severe clinical CVD. 2…”

O efeito da sulfadiazina de prata, extrato de ipê-roxo e extrato de barbatimão na cicatrização de feridas cutâneas em ratos

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“…Este modelo animal também foi descrito por outros autores que utilizaram a ligadura de grandes veias para confeccionar um modelo que contribuísse para estudos que necessitavam de alteração da circulação 13,14 . Esta alteração foi confirmada neste experimento por meio da perimetria crural realizada antes e depois da ligadura da veia femoral.…”