Experimental Procedures and ResultsAnticipating hypoglycaemia at many points in the 24 hours, a " pilot " experiment using two rats was performed. It was found that small amounts of protamine zinc insulin were well tolerated by the hypophysectomized animals, and that when a suitable diet was made available at all times constant attention became unnecessary. Before this goal was reached in this experiment one animal succumbed to hypoglycaemia, but the other grew rapidly, nearly doubling its weight in 20 days, and it served as a model for the many larger series of animals which have subsequently been studied. In this rat it was found that the tail had lengthened by I cth. during the 20 days of insulin therapy. At necropsy the thymus, kidney, and heart weights were within the normal range. The liver was heavier than normal. The testes, adrenals, and thyroid were atrophic. Experiment A.-In this experiment 40 male rats, 14 days after hypophysectomy, were divided into three groups of TABLE

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