Evaluation of the Relationship Between Retinal Nerve Fiber Layer and Ganglion Cell Complex Measured by Optical Coherence Tomography in Glaucomatous and Normal Cases

Korkmaz, Bülent; Tiğit, Ulviye; Ağaçhan, Ahmet; Helvacıoğlu, Fırat; Bilen, Harun; Tuğcu, Betül

doi:10.4274/tjo.40.338

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…15 Current OCT devices can obtain mGCC measurements automatically, and studies report that a decrease in mGCC thickness has high diagnostic value in early glaucoma, similar to RNFL parameters. 11,15,16,17,18,19,20,21,22,23 Reported mGCC thickness values range between 76.6 and 119.8 µm in normal eyes and between 53.6 and 99.1 µm in perimetric glaucomatous eyes. 16 Because the range of mGCC thickness overlaps in normal and glaucomatous eyes, Kita et al 15 compared various macular parameters in Japanese patients and demonstrated that the ratio of mGCC thickness to total retinal thickness (G/T ratio) was the parameter with the highest diagnostic value in glaucoma.…”

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confidence: 99%

The Diagnostic Ability of Ganglion Cell Complex Thickness-to-Total Retinal Thickness Ratio in Glaucoma in a Caucasian Population

Sezenöz¹,

Güngör²,

Akman³

et al. 2020

tjo

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Introduction Glaucoma is a progressive optic neuropathy characterized by retinal ganglion cell loss and thinning of the retinal nerve fiber layer (RNFL). 1,2 Glaucomatous visual field defects emerge after 30% of the retinal ganglion cells are lost. Therefore, structural tests are important in the early diagnosis and follow-up of glaucoma. 3 Previous optical coherence tomography (OCT) studies demonstrated peripapillary RNFL thinning in early Objectives: To evaluate the diagnostic accuracy of the macular ganglion cell complex-to-total retinal thickness (G/T) ratio in a Caucasian population. Materials and Methods: A total of 86 patients were enrolled in this cross-sectional study. Patients were divided into 4 groups: healthy; ocular hypertension; preperimetric glaucoma; and early glaucoma. Macular ganglion cell complex (mGCC) thickness, total retinal thickness, and retinal nerve fiber layer thickness (RNFLT) in one randomly selected eye of each patient were measured with measured with Heidelberg HD spectral domain optical coherence tomography (Heidelberg Engineering, Inc., Heidelberg, Germany). G/T ratio (%) was calculated as (mGCC thickness / total retinal thickness) x100. The ability of each parameter to diagnose glaucoma was examined by area under the receiver operating characteristic curve (AUROC) analysis and sensitivity evaluation at a fixed level of specificity. Unpaired t test was used to compare the measured values between the healthy subjects and the different patient groups. Results: The study included 9 healthy individuals, 18 patients with ocular hypertension, 28 with preperimetric glaucoma, and 31 with early glaucoma. Total retinal thickness, mGCC thickness, RNFLT, and G/T ratio were highest in the healthy group and decreased progressively in patients with ocular hypertension, preperimetric glaucoma, and early glaucoma. All comparisons between the groups were significant for these parameters (p<0.001 for all). Average RNFLT, average GCC, and total retinal thickness showed consistently higher AUROC than G/T ratio in the differentiation between healthy individuals and patients with ocular hypertension, preperimetric glaucoma, and early glaucoma. Conclusion: G/T ratio does not contribute to separation of ocular hypertension, preperimetric glaucoma, and early glaucoma patients from the healthy population. Compared to the other parameters investigated, G/T had lower diagnostic value.

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confidence: 99%

The Diagnostic Ability of Ganglion Cell Complex Thickness-to-Total Retinal Thickness Ratio in Glaucoma in a Caucasian Population

Sezenöz¹,

Güngör²,

Akman³

et al. 2020

tjo

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“…The use of OCT has become increasingly common to measure RNFL thickness and optic nerve head parameters in the diagnosis and management of glaucoma. 7 Although split bundles appear to be a normal finding that does not indicate disease, they may affect GDx and OCT parameters and be mistaken for wedge defect. In contrast to split bundles, wedge defects are separated from adjacent tissue with sharper margins and occur with glaucomatous changes in the optic nerve.…”

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Prevalence of Split Nerve Fiber Layer Bundles in Healthy People Imaged with Spectral Domain Optical Coherence Tomography

Güngör

Akman

Sezenöz

et al. 2016

tjo

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Objectives: The presence of retinal nerve fiber layer (RNFL) split bundles was recently described in normal eyes scanned using scanning laser polarimetry and by histologic studies. Split bundles may resemble RNFL loss in healthy eyes. The aim of our study was to determine the prevalence of nerve fiber layer split bundles in healthy people.Materials and Methods: We imaged 718 eyes of 359 healthy persons with the spectral domain optical coherence tomography in this cross-sectional study. All eyes had intraocular pressure of 21 mmHg or less, normal appearance of the optic nerve head, and normal visual fields (Humphrey Field Analyzer 24-2 full threshold program). In our study, a bundle was defined as ‘split’ when there is localized defect not resembling a wedge defect in the RNFL deviation map with a symmetrically divided RNFL appearance on the RNFL thickness map. The classification was performed by two independent observers who used an identical set of reference examples to standardize the classification.Results: Inter-observer consensus was reached in all cases. Bilateral superior split bundles were seen in 19 cases (5.29%) and unilateral superior split was observed in 15 cases (4.16%). In 325 cases (90.52%) there was no split bundle.Conclusion: Split nerve fiber layer bundles, in contrast to single nerve fiber layer bundles, are not common findings in healthy eyes. In eyes with normal optic disc appearance, especially when a superior RNFL defect is observed in RNFL deviation map, the RNLF thickness map and graphs should also be examined for split nerve fiber layer bundles.

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Structural Changes in Pseudoexfoliation Syndrome Evaluated with Spectral Domain Optical Coherence Tomography

Eltutar¹,

Acar²,

Öztürker³

et al. 2015

Current Eye Research

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Evaluation of the Relationship Between Retinal Nerve Fiber Layer and Ganglion Cell Complex Measured by Optical Coherence Tomography in Glaucomatous and Normal Cases

Cited by 3 publications

References 11 publications

The Diagnostic Ability of Ganglion Cell Complex Thickness-to-Total Retinal Thickness Ratio in Glaucoma in a Caucasian Population

The Diagnostic Ability of Ganglion Cell Complex Thickness-to-Total Retinal Thickness Ratio in Glaucoma in a Caucasian Population

Prevalence of Split Nerve Fiber Layer Bundles in Healthy People Imaged with Spectral Domain Optical Coherence Tomography

Structural Changes in Pseudoexfoliation Syndrome Evaluated with Spectral Domain Optical Coherence Tomography

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