Evaluation of the relationship between caries indices and salivary secretory IgA, salivary pH, buffering capacity and flow rate in children with Down's syndrome

Effect of fluoride on salivary immunoglobulins and sialic acid

“…These antibodies may reduce the initial adhering of bacteria to saliva-coated teeth surfaces and neutralize extracellular enzymes. 7 It has been reported that caries-free patients have significantly higher levels of naturally occurring salivary sIgA compared with caries-active subjects. 8 Results of previous studies have led researchers to believe that there is a negative correlation between salivary sIgA and dental caries.…”

<p>Prevalensi sindroma Down di wilayah Priangan pada tahun 2015</p<p>Prevalence of Down syndrome at the Priangan area in 2015</p>

“…1 Penyebab lainnya adalah kelainan genetik berupa translokasi kromosom dan mosaik yang terjadi pada 5-10% kasus Sindroma Down. 2 Selain itu, terdapat pula beberapa faktor resiko yang menyebabkan terjadinya kelahiran Sindroma Down, yaitu faktor radiasi, faktor ayah dan faktor ibu.…”

Down Syndrome: A Review for the Dental Professionals

“…b) Salivary pH and buffering capacity: Conflicting results as some studies showed higher values, while others showed no difference, and others showed lower values. [34,37,38,40] c) High salivary IgA concentration "immune protection", and high salivary bicarbonate and minerals. [37] d) Associated with the parent's greater concern about oral health care in DS.…”

“…[29][30][31][32][33] However, most investigators have found a lower prevalence of caries in DS patients in both dentitions. [34][35][36][37][38] This low caries incidence in children with DS is in spite of the presence of increased risk factors for caries such as cariogenic diet, decreased salivary flow rate, [34,39,40] mouth breathing, imbalanced occlusal forces and poor access to oral hygiene. [37] Caries risk assessment is likely to be obtained by evaluation factors such as a high sugar or acidic diet, frequency of snacking, low social status, appropriate oral health and past dental history.…”

“…[37] Caries risk assessment is likely to be obtained by evaluation factors such as a high sugar or acidic diet, frequency of snacking, low social status, appropriate oral health and past dental history. [37] The precise cause of the lower caries prevalence is still unclear. The proposed reasons are as follow: a) Dental anomalies: Delayed eruption, microdontia and spaced teeth due to hypodontia will reduce caries risk.…”