Evaluation of the Potential Nephroprotective and Antimicrobial Effect ofCamellia sinensisLeaves versusHibiscus sabdariffa(In VivoandIn VitroStudies)

Ibrahim, Doa’a Anwar; Al-Badani, Rowida

doi:10.1155/2014/389834

Cited by 10 publications

(12 citation statements)

References 26 publications

(26 reference statements)

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“…Camellia sinensis and Aloysia citrodora exhibited wide spectra of antimicrobial activity in comparison to Hibiscus sabdariffa, Glycyrrhiza glabra, and Thymus vulgaris (Table 3). Among the three tested bacterial species, Camellia sinensis extract showed the highest antibacterial activity against S. aureus (MRSA and MSSA), exhibiting the lowest MIC value (0.5 mg/mL) which is in agreement with the report of [22]. Additionally, Camellia sinensis has anti-bacterial activity against MDR P. aeruginosa, which is similar to a previous report [32].…”

Section: Discussionsupporting

confidence: 90%

“…ESBL E. coli were affected by Phlomis brachyodon, Pallenis spinosa, Urtica pilulifera, Anchusa azurea, Aloysia citrodora, and Hibiscus sabdariffa. Camellia sinensis showed the greatest antimicrobial effect when compared to the other plants, this is in agreement with the results of [22]. In contrast, P. aeruginosa was not affected by any of the extracts except Hibiscus sabdariffa and not in agreement with the results of [22] results that Hibiscus sabdariffa extract had no antimicrobial activity against Gram positive and Gram negative bacteria.…”

Section: Discussionsupporting

confidence: 88%

“…The plant extract discs and antibiotic discs were applied on the surface of Mueller Hinton Agar MHA (Oxoid, UK) plates and incubated under aerobic conditions at 37 • C for 24 h. The tests were carried out in triplicate. Zone of inhibition ≥11 mm indicates susceptibility of the tested bacteria and consider as high antibacterial activity [22]. The inhibition of bacterial growth was evaluated by measuring the diameter (mm) of the clear zone around each disc [23].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial Efficacy of Some Medicinal Plants on Multidrug Resistance Bacteria and Their Toxicity on Eukaryotic Cells

2021

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The aim of this study was to evaluate the in vitro antimicrobial activity of medicinal Methanolic plant extracts against multidrug-resistant bacteria to determine the cytotoxicity of these extracts on eukaryotic cells, and to confirm their efficacy against Methicillin-Resistant Staphylococcus aureus (MRSA) in experimental animals. The effects of the methanol extract of sixty folk plants were investigated on; MRSA, Extended Spectrum Beta-Lactamase E. coli and MDR Pseudomonas aeruginosa by disc diffusion and MIC assay. Cytotoxicity was determined using MTT and hemolysis of human erythrocytes. Three plant extracts with the highest antimicrobial activities were tested using a challenge experiment on mice. Systemic infection was performed by intraperitoneal inoculation of (5 × 106 CFU/mL) of MRSA isolate. Then mice received 300 mg/kg body weight of the plant extracts daily for seven days. The efficacy of plant extracts was evaluated by general health, mortality rate, gross lesion, and histopathology study of inoculated mice. Only ten plants showed activities against different MDR bacteria with inhibitory zones ranging from (8 to 22 mm) in diameter. Of the ten medicinal plant extracts, and Aloysia citrodora showed the highest activities against MRSA and Camellia sinensis MSSA isolates, with MIC values ranging from 0.5 to 1.5 mg/mL, followed by Hibiscus sabdariffa, Thymus vulgaris, and Glycyrrhiza glabra. Furthermore, the extract of the effective plants showed low toxicity against Vero and fibroblasts cell lines, along with inhibitory activities to erythrocytes membrane disruption. The in vivo study demonstrated that Camellia sinensis showed significant activity against MRSA infections in mice. The results validate that these plants are effective and safe antibacterial agents against multidrug-resistance bacteria, and have the potential to be utilized as an alternative to antibiotics for the treatment of bacterial infections.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Antibacterial Efficacy of Some Medicinal Plants on Multidrug Resistance Bacteria and Their Toxicity on Eukaryotic Cells

2021

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“…Green tea, an aqueous extract made from the leaves of Camellia sinensis , is revered throughout Asia for its reputed health benefits [111]. Centuries of anecdotal evidence has been experimentally validated by demonstrating that Camellia sinensis has antioxidant [112], anti-inflammatory [113], antimicrobial [114], anticarcinogenic [115], antiaging [116], antiobesity [117, 118], cardioprotective [119], and neuroprotective [120] activities. Catechins, the polyphenolic compounds from Camellia sinensis , are primarily responsible for these pharmacological activities [121].…”

Section: Traditional Use Of Medical Plants In Wound Healingmentioning

confidence: 99%

Wound Healing and the Use of Medicinal Plants

Shedoeva

Leavesley

Upton

et al. 2019

Evidence-Based Complementary and Alternative Medicine

233

164

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Cutaneous wound healing is the process by which skin repairs itself. It is generally accepted that cutaneous wound healing can be divided into 4 phases: haemostasis, inflammation, proliferation, and remodelling. In humans, keratinocytes re-form a functional epidermis (reepithelialization) as rapidly as possible, closing the wound and reestablishing tissue homeostasis. Dermal fibroblasts migrate into the wound bed and proliferate, creating “granulation tissue” rich in extracellular matrix proteins and supporting the growth of new blood vessels. Ultimately, this is remodelled over an extended period, returning the injured tissue to a state similar to that before injury. Dysregulation in any phase of the wound healing cascade delays healing and may result in various skin pathologies, including nonhealing, or chronic ulceration. Indigenous and traditional medicines make extensive use of natural products and derivatives of natural products and provide more than half of all medicines consumed today throughout the world. Recognising the important role traditional medicine continues to play, we have undertaken an extensive survey of literature reporting the use of medical plants and plant-based products for cutaneous wounds. We describe the active ingredients, bioactivities, clinical uses, formulations, methods of preparation, and clinical value of 36 medical plant species. Several species stand out, including Centella asiatica, Curcuma longa, and Paeonia suffruticosa, which are popular wound healing products used by several cultures and ethnic groups. The popularity and evidence of continued use clearly indicates that there are still lessons to be learned from traditional practices. Hidden in the myriad of natural products and derivatives from natural products are undescribed reagents, unexplored combinations, and adjunct compounds that could have a place in the contemporary therapeutic inventory.

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“…The presence of certain pathogenic bacterial strains tea, exhibited antioxidant [27] , anti-inflammatory [28] and antimicrobial [29] activities.…”

Section: Resultsmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of the Wound Healing Potential of the Extracts of Schinus molle L. (Anacardiaceae) Grown in Jordan

Aboalhaija¹,

Afifi²,

Al‐Hussaini³

et al. 2021

ijps

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The aim of this study was to assess the wound healing potential of Schinus molle L. aqueous and ethanol extracts. First, the antimicrobial activity of Schinus molle extracts was tested against six microorganisms (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, Enterococcus faecalis and Citrobacter freundii). The growth of Citrobacter freundii and Enterococcus faecalis was totally inhibited by the aqueous extract at the lowest tested concentration (1.56 mg/mL). Next, in vitro wound healing assays were performed using human fibroblast cells' proliferation and scratch tests. Based on the obtained promising results, the aqueous extracts were further tested in an in vivo excision wound model in rats. Animals were treated with a hydrogel formula enriched with the plant aqueous extract in two different concentrations (2 % and 5 %). Re-epithelialization, fibrosis and neovascularization of the epidermis and sub-epidermal cells in the regenerated tissue was observed, accompanied by an increase in the tensile strength of the skin of the rats treated with the plant aqueous extract when compared to the negative control group. Our results strongly support the use of Schinus molle aqueous extracts in topical formulations to promote wound healing.

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Evaluation of the Potential Nephroprotective and Antimicrobial Effect ofCamellia sinensisLeaves versusHibiscus sabdariffa(In VivoandIn VitroStudies)

Cited by 10 publications

References 26 publications

Antibacterial Efficacy of Some Medicinal Plants on Multidrug Resistance Bacteria and Their Toxicity on Eukaryotic Cells

Antibacterial Efficacy of Some Medicinal Plants on Multidrug Resistance Bacteria and Their Toxicity on Eukaryotic Cells

Wound Healing and the Use of Medicinal Plants

In Vitro and In Vivo Evaluation of the Wound Healing Potential of the Extracts of Schinus molle L. (Anacardiaceae) Grown in Jordan

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