Evaluation of the permeability and blood‐compatibility properties of membranes formed by physical interpenetration of chitosan with PEO/PPO/PEO triblock copolymers

Anderson, Derick; Nguyen, Tragiang; Lai, Phung-Kim; Amiji, Mansoor M.

doi:10.1002/app.1213

Cited by 16 publications

(6 citation statements)

References 28 publications

(24 reference statements)

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“…Thus, the encapsulation and leakage efficiency of the probe molecules could reflect the permeability of the membrane directly. The characteristics of probes utilized for permeability estimation are shown in Table 2, Vitamin B 2 and Vitamin B 12 are frequently utilized for detecting the permeability of the membrane of capsules, 30,31 other probes are proteins or enzyme which have similar isoelectric point (pI) and structure. Proteins can be classified as complex ampholytes, they are generally charged and can electrostatically interact with charged components of the capsule.Thus, in addition to steric hindrance, electrostatic interactions can also influence permeability measurements with proteins.…”

Section: The Permeability Of Alg-g-peg/a-cd Hollow Nanospheresmentioning

confidence: 99%

Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres

Meng

et al. 2011

Soft Matter

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This paper presents a kind of self-assembled hollow nanosphere for enzyme encapsulation. The enzyme molecules were encapsulated in hollow spheres directly in aqueous solution through the self-assembly of rod-coil Alg-g-PEG and a-CDs complexes. These Alg-g-PEG/a-CD hollow spheres showed semipermeability which could prevent big enzyme molecules from leaving while allowing small substrates and products to pass through to maintain the enzyme activity. The permeability properties of Alg-g-PEG/a-CD hollow nanospheres were investigated by encapsulating different probes. The results showed that the molar mass cutoff (MMCO) of these hollow nanospheres was between 20 and 40 kDa. The encapsulation capability of Alg-g-PEG/a-CD hollow nanospheres was also investigated, the results indicated a maximal values for L-asparaginase encapsulation. Furthermore, the encapsulation behavior for L-asparaginase showed PEG graft density (GD) dependence.

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Section: The Permeability Of Alg-g-peg/a-cd Hollow Nanospheresmentioning

confidence: 99%

Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres

Meng

et al. 2011

Soft Matter

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“…The peak separation was performed by the established method reported for C-C and C-H (peak 1), C-O (peak 2), C-NH (peak 3) and O-C¼O (peak 4). [38][39][40][41] The total curve (dotted curve) corresponding to the summation of each peak magnitude gave the best fit with respect to the measured curve (solid curve). The peak area fractions of the specimens are listed in Table 1.…”

Section: Surface Properties Of the Blendsmentioning

confidence: 99%

Structure and Mechanical Properties of Chitosan/Poly(Vinyl Alcohol) Blend Films

Nakano

Bin

Bando

et al. 2007

Macromolecular Symposia

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The origins of the thermal and mechanical properties of chitosan and poly(vinyl alcohol) (PVA) with inter-and intra-hydrogen bonds were investigated systematically by using X-ray, DSC, positron annihilation and viscoelastic measurements. Based on their individual properties, the characteristics of the blend films were estimated in relation to their morphology and mechanical properties as a function of chitosan content. The characteristics of the blend films were also analyzed in terms of the deviation from a simple additive rule of chitosan and PVA content. These results suggested that the miscibility of chitosan and PVA could be ensured by entanglement of the amorphous chain segments of chitosan and PVA. Further detailed analysis revealed that the chitosan content on the film surface is higher than that of the admixture content of chitosan after elongation, although the chitosan and PVA chains were crystallized independently. The elongation could be achieved for the blend films whose PVA content was higher than 50% and the drawn blend films were transparent. Thus, it may be expected that sufficiently entangled meshes formed between chitosan and PVA amorphous chains within the film, the PVA content being higher than 50%, were maintained under the elongation process.

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“…9 The effects of cellulose and the additive material on blood was not investigated in these studies. 19,20 The motivation of this study, therefore, was to find a membrane that had less influence on and interaction with the blood and also resulted in higher permeation rates of urea and creatinine. Increases in the cellulose concentration and a decrease in the coagulant temperature increased the sieving coefficients of dextran.…”

Section: Introductionmentioning

confidence: 99%

“…17,18 Cellulosic membranes, even though they have been used for dialysis for some time, still raise concerns because of their ability to enhance the blood-clotting process. 19,20 The motivation of this study, therefore, was to find a membrane that had less influence on and interaction with the blood and also resulted in higher permeation rates of urea and creatinine. For membrane preparation, polyamide (nylon 66) was selected as the polymer.…”

Section: Introductionmentioning

confidence: 99%

Influence of monosodium glutamate additive on the morphology and permeability characteristics of polyamide dialysis membranes

Shakaib

Ahmed

Yunus

et al. 2012

J of Applied Polymer Sci

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Membranes were prepared with dope solutions of various concentrations of polyamide and monosodium glutamate (MSG) additive for dialysis applications. The results show that the membranes with higher MSG concentrations had higher water uptakes and porosities. The membranes were characterized with scanning electron microscopy (SEM) and atomic force microscopy techniques and evaluated in terms of the permeability of solutes, such as urea and creatinine. The cross-sectional structure of the membranes prepared without MSG additive or with a low MSG concentration were dense, and their surfaces consisted of large-sized nodule aggregates. The permeation of solutes was less through these membranes. When the amount of additive in the membrane solution was sufficient, macrovoids were seen in the SEM images, and the sizes of nodules were small, which caused an increase in the diffusive permeability of solutes. The surfaces of the membranes with higher MSG concentrations were found to be smooth; this could be useful for the dialysis process. The contact angles of these membranes were also lower; this indicated that this additive improved the hydrophilicity of the membranes.

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Evaluation of the permeability and blood‐compatibility properties of membranes formed by physical interpenetration of chitosan with PEO/PPO/PEO triblock copolymers

Cited by 16 publications

References 28 publications

Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres

Encapsulation studies and selective membrane permeability properties of self-assembly hollow nanospheres

Structure and Mechanical Properties of Chitosan/Poly(Vinyl Alcohol) Blend Films

Influence of monosodium glutamate additive on the morphology and permeability characteristics of polyamide dialysis membranes

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