Evaluation of the kinetic and relaxation time of gentamicin sulfate released from hybrid biomaterial Bioglass-chitosan scaffolds

Wers, Éric; Oudadesse, Hassane; Lefeuvre, Bertrand; Merdrignac‐Conanec, Odile; Barroug, Allal

doi:10.1016/j.apsusc.2015.06.146

Cited by 28 publications

(11 citation statements)

References 36 publications

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“…This finding explains the high reactivity of the 46S6 surface to the molecules of biological interest. Additionally, this result explains that resedronate presents an early release due to its hydrophilic character, the same results is reported in previous works after the immersion of gentamicin sulfate in the PBS solution [41].…”

Section: Analysis Of the Solutions After Uptake Of Risedronates (Solusupporting

confidence: 89%

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Mosbahi

Oudadesse

Lefeuvre

et al. 2016

Applied Surface Science

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International audienceThe aim of the current work is to study the physicochemical interactions between bisphosphonates molecules, risedronate (RIS) and bioactive glass (46S6) after their association by adsorption phenomenon. To more understand the interaction processes of RIS with the 46S6 surface we have used complementary physicochemical techniques such as Infrared (FTIR), RAMAN and nuclear magnetic resonance (NMR) spectroscopy. The obtained results suggest that risedronate adsorption corresponds to an ion substitution reaction with silicon ions occurring at the bioactive glass surface. Thus, a pure bioactive glass was synthesized and fully characterized comparing the solids after adsorption (46S6-XRIS obtained after the interaction of 46S6 and X% risedronate). Therefore, based on the spectroscopic results FTIR, RMAN and MAS-NMR, it can be concluded that strong interactions have been established between RIS ions and 46S6 surface. In fact, FTIR and RAMAN spectroscopy illustrate the fixation of risedronate on the bioactive glass surface by the appearance of several bands characterizing risedrontre. The 31P MAS-NMR of the composite 46S6-XRIS show the presence of two species at a chemical shift of 15 and 19 ppm demonstrating thus the fixation of the RIS on 46S6 surface

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Section: Analysis Of the Solutions After Uptake Of Risedronates (Solusupporting

confidence: 89%

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Mosbahi

Oudadesse

Lefeuvre

et al. 2016

Applied Surface Science

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“…In the field of biomedical research, many different compositions were studied for their biocompatible properties and their actions within the body. Bioactive glass in the SiO 2 -Na 2 O-CaO-P 2 O 5 system has been widely studied and their utility in the bone restoration area has been accepted [1][2][3][4][5]. Since their invention [6][7][8], synthetic biomaterials have been considered a good option for replacing biological bone grafts.…”

Section: Introductionmentioning

confidence: 99%

Fine analysis of interaction mechanism of bioactive glass surface after soaking in SBF solution: AFM and ICP-OES investigations

Rocton

Oudadesse

Lefeuvre

et al. 2020

Applied Surface Science

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Bioactive glasses have the physical characteristics enabling them to be used in bone tissue engineering applications. However, the exact mechanism of the interactions between the glass surface and environment leading to the transition from the vitreous phase to the crystalline phase remains a subject of study. This work focuses on the growth of a calcium phosphate layer on the surface of the glass after immersion in a mineral solution, which mimics the mineral phase of human blood. The investigations use the Inductively Coupled Plasma and the Atomic Force Microscopy to establish the kinetic of crystallization, the kinetic of chemical reactivity and the surface transformations such as structure, texture and morphology of the bioactive glass. Obtained results show the progressive formation of a hydroxyapatite layer within 2 weeks. This crystal which is that of the bone belongs to the crystallographic structure within space group of P6 3/m. In addition, results show a decrease of the gradient of thickness which varies according to the immersion time from 7.5 µm to 2.8 µm and an increase of the homogeneity of the surface visible by the lowering of the gradient in the phase measurement from 60 Å to 15 Å.

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“…The fabricating methods of porous ceramics include solvent-casting particle leaching, freeze-drying, and the foam exchange technique. These manufacturing processes can replicate the 3D porous structure in bone tissue engineering [4][5][6]. Among these methods, the foam exchange technique is a simple strategy which can provide a highly interconnected structure.…”

Section: Introductionmentioning

confidence: 99%

Novel Epigallocatechin-3-Gallate (EGCG)-Loaded Mesoporous Bioglass Scaffolds for Bone Recruitment Applications

Ou¹,

Tsao

Lin

et al. 2020

Applied Sciences

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Bioglass-based material has been widely used in the field of biomedical science. In this study, the proper concentration of epigallocatechin-3-gallate (EGCG) for a mesoporous bioglass (MBG) scaffold was determined based on the sponge replication method. The fabrication procedure performed using a foam exchange technique resulted in an interconnected network of pores scaffolds with no cracks. In the minimum bactericidal concentrations of the bacteria assessed, the antibacterial concentration of EGCG against E. coli (200 μg/mL) was higher than that against S. aureus (25 μg/mL). The MBG and EGCG-MBG scaffolds exhibited excellent apatite mineralization and drug release abilities (the highest cumulative drug release from the EGCG-MBG scaffold was 75.37%). Thus, a 200 μg/mL EGCG can prevent cell apoptosis and directly enhance cell proliferation. Hence, a low-dose EGCG-MBG scaffold is another option for bone recruitment material.

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Evaluation of the kinetic and relaxation time of gentamicin sulfate released from hybrid biomaterial Bioglass-chitosan scaffolds

Cited by 28 publications

References 36 publications

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Fine analysis of interaction mechanism of bioactive glass surface after soaking in SBF solution: AFM and ICP-OES investigations

Novel Epigallocatechin-3-Gallate (EGCG)-Loaded Mesoporous Bioglass Scaffolds for Bone Recruitment Applications

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