Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Abstract

International audienceThe aim of the current work is to study the physicochemical interactions between bisphosphonates molecules, risedronate (RIS) and bioactive glass (46S6) after their association by adsorption phenomenon. To more understand the interaction processes of RIS with the 46S6 surface we have used complementary physicochemical techniques such as Infrared (FTIR), RAMAN and nuclear magnetic resonance (NMR) spectroscopy. The obtained results suggest that risedronate adsorption corresponds to an ion substitution reaction with silicon ions occurring at the bioactive glass surface. Thus, a pure bioactive glass was synthesized and fully characterized comparing the solids after adsorption (46S6-XRIS obtained after the interaction of 46S6 and X% risedronate). Therefore, based on the spectroscopic results FTIR, RMAN and MAS-NMR, it can be concluded that strong interactions have been established between RIS ions and 46S6 surface. In fact, FTIR and RAMAN spectroscopy illustrate the fixation of risedronate on the bioactive glass surface by the appearance of several bands characterizing risedrontre. The 31P MAS-NMR of the composite 46S6-XRIS show the presence of two species at a chemical shift of 15 and 19 ppm demonstrating thus the fixation of the RIS on 46S6 surface

Risedronate Effects on the In Vivo Bioactive Glass Behavior: Nuclear Magnetic Resonance and Histopathological Studies

“…Risedronate content in the SBF solution was quanti ed using UV spectroscopy absorption at 262 nm as reported in our previous work [14] in order to evaluate the kinetic of drug release in the SBF solution during 1, 15 and 30 days of immersion [14].…”

“…Risedronate 46S6 F 4: Morphologies of 46S6 [25], risedronate, 46S6-8RIS, 46S6-12RIS and 46S6-20RIS before immersion in the SBF solution [14].…”

“…(a) FTIR spectra of 46S6, risedronate, 46S6-8RIS, 46S6-12RIS and 46S6-20RIS composites before soaking in the SBF solution[14]. (b) Infrared spectra of 46S6, 46S6-8RIS, 46S6-12RIS, 46S6-20RIS and HA before a er 1 day of immersion in the SBF solution.…”

Theoretical study of the deposition and adsorption of bisphosphonates on the 001 hydroxyapatite surface: Implications in the pathological crystallization inhibition and the bone antiresorptive action

“…Due to its biological relevance and medical applications [3,4], the HAP has been extensively studied both experimentally [5,6] and computationally [7,8] to understand and characterize its macroscopic and chemical structure. In addition, it has been studied the interaction of the HAP surfaces with some biomolecules [9][10][11][12][13][14][15]. On the other hand, HAP has also become to an interesting object of research because it is involved in diverse pathological bio-mineral depositions, resulting in problems such as dental calculus, arthritis, arteriosclerosis, and urinary calculi [16][17][18].…”