Evaluation of the Importance of Maternal History of Diabetes and of Mitochondrial Variation in the Development of NIDDM

Mother to child transmission of diabetes mellitus: does gestational diabetes program Type 2 diabetes in the next generation?

“…Some previous studies have recognized that individuals with overt T2DM more often report a history of diabetes in their mother than in their father [5,6], although this has been contradicted by others [7,8]. We have taken a different approach, identifying groups of women according to their family history of diabetes and then testing them for hyperglycaemia at a time of increased susceptibility.…”

Is human Type 2 diabetes maternally inherited? Insights from an animal model

“…A single large prospective study, where data was available on parents and offspring, failed to confirm excessive maternal transmission [3]. A smaller study in Indian families came to a similar conclusion [4].…”

Cosegregation of obesity with familial aggregation of type 2 diabetes mellitus

“…Epidemiological studies in urban southern Indians have shown that they have a high prevalence of type 2 diabetes and impaired glucose tolerance[1–2], and they also have a clustering of cardiovascular risk factors or the presence of ‘syndrome X’[3]. It has also been noted in the epidemiologically‐[1–3] and clinically‐based[4,5–6] studies that they have a high familial aggregation of type 2 diabetes. Offspring of diabetic parents show a high risk of diabetes and the risk is shown to increase with an increasing family history of diabetes[6,7].…”

“…The risk factors for diabetes in Indians include: positive family history of diabetes; body mass index (b.m.i. ); upper body adiposity indicated by the waist‐to‐hip ratio (WHR); and urbanization[2–16]. They also have insulin resistance indicated by hyperinsulinaemia[2,17].…”