Cosegregation of obesity with familial aggregation of type 2 diabetes mellitus

Ramachandran, Ambady; Snehalatha, Chamukuttan; Kumpatla, Satyavani; Sivasankari, S.; Vijay, V.

doi:10.1046/j.1463-1326.2000.00067.x

Cited by 29 publications

(19 citation statements)

References 29 publications

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“…These four factors could be identified as central obesity (factor 1), centralized subcutaneous fat (factor 2), lipid profile blood glucose (factor 3), and blood pressure (factor 4). The lack of overlap of central obesity measure, as evident in the study, was also observed in other studies concerning the Asian Indians [27,30,31]. Four distinct cluster domains with almost 70% explanation were also observed in south Indian non-diabetic male subjects [30].…”

Section: Discussionsupporting

confidence: 87%

Factor analysis of metabolic syndrome among the middle‐aged Bengalee Hindu men of Calcutta, India

Ghosh

2004

Diabetes Metabolism Res

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Section: Discussionsupporting

confidence: 87%

Factor analysis of metabolic syndrome among the middle‐aged Bengalee Hindu men of Calcutta, India

Ghosh

2004

Diabetes Metabolism Res

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“…Glucose metabolism risk factors are determined by genetic and early environmental influences [14][15][16]. First-degree relatives (FDRs) of patients with type 2 diabetes have a common genetic basis, and are at increased risk of glucose intolerance and diabetes.…”

Section: Introductionmentioning

confidence: 99%

Normal Fasting Plasma Glucose and Risk of Prediabetes and Type 2 Diabetes: The Isfahan Diabetes Prevention Study

Janghorbani

Amini²

2011

Rev Diabet Stud

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■ Abstract AIM:To determine the association of fasting plasma glucose (FPG) level within normal range and the risk of prediabetes and type 2 diabetes in an Iranian population. METH-ODS: A total of 806 first-degree relatives (FDRs) of patients with type 2 diabetes who had FPG levels less than 5.6 mmol/l (100 mg/dl) in 2003 to 2005, and who did not have diabetes or impaired fasting glucose (IFG), were followed through 2010 for the occurrence of prediabetes or type 2 diabetes. At baseline and through follow-ups, participants underwent a standard 75 g 2-hour oral glucose tolerance test (OGTT). RESULTS: The incidence of type 2 diabetes, impaired glucose tolerance (IGT), and IFG was 9.6 (95% confidence interval (CI): 6.8-12.4), 28.7 (23.8-33.6), and 33.0 (27.7-38.2) per 1,000 person-years based on 4,489 person-years of follow-up, respectively. FPG was associated with the incidence of diabetes, IGT, and IFG. The multivariate-adjusted hazard ratios (95% CI) for diabetes, IGT, and IFG were 1.36 (1.01-1.84), 1.45 (1.10-1.91) and 1.31 (1.00-1.71), for the highest quintile of FPG compared with the lowest quintile, respectively. CONCLUSIONS: An increase in FPG in the normal range is associated with an increase in the incidence of IGT, IFG, and type 2 diabetes. These results prove FPG in the normal range to be useful in identifying apparently healthy FDRs of patients with type 2 diabetes at risk of developing prediabetes and diabetes.

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“…However, Sicree et al referred to fixed glucose load as the main cause of gender difference in response to OGTT, and it is likely that genetic factors also influence gender difference in response to OGTT. Height [15,16] and glucose metabolism risk factors [17][18][19][20] such as obesity are determined by genetic and early environmental influences. First-degree relatives (FDR) of patients with type 2 diabetes are genetically predisposed to a high risk of glucose intolerance and might be more appropriate for testing this hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Effects of Gender and Height on the Oral Glucose Tolerance Test: The Isfahan Diabetes Prevention Study

Janghorbani

Amini²

2008

Rev Diabet Stud

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■ AbstractBACKGROUND: Impaired fasting glucose (IFG) is more prevalent in men, whereas impaired glucose tolerance (IGT) is more prevalent in women. AIM: To determine whether gender difference in the prevalence of glucose intolerance is related to height. METHODS: A cross-sectional study of 2,368 first-degree relatives (FDR) of patients with type 2 diabetes was conducted between years 2003 to 2005. All participants (614 men and 1754 women) were in the age range 30-60 years, and were FDR of consecutive patients from outpatient clinics at Isfahan Endocrine and Metabolism Research Centre, Iran. All subjects underwent a standard 75 g 2-h oral glucose tolerance test (OGTT). Weight, height, waist and hip circumference, and glycated haemoglobin were also measured. RESULTS: IGT was more common amongst women (OR 0.66; 95% CI 0.51, 0.87),whereas diabetes (OR 1.31; 95% CI 0.96, 1.78), and IFG (OR 1.41; 95% CI 1.10, 1.80) was more common amongst men. Women had a lower mean fasting plasma glucose (FPG) (p < 0.001), but showed higher 2hPG, and FPG-2hPG increase (p < 0.001). The gender difference in mean 2hPG and FPG2hPG increase, was not evident after adjustment for height. Negative correlation to height was observed in 2hPG and FPG-2hPG increase, both in men and women (p < 0.001), but height showed little association with FPG. CONCLU-SIONS: Women had higher mean 2hPG and FPG-2hPG increase, but showed a lower FPG level than men. The inverse association between height and 2hPG and FPG-2hPG increase may be explained by gender difference.

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Cosegregation of obesity with familial aggregation of type 2 diabetes mellitus

Abstract: In this population, general and central obesity are associated with a family history of diabetes. A family history of diabetes may increase the risk of hypertension and hyperlipidaemia indirectly through its connection with b.m.i.

Cited by 29 publications

References 29 publications

Factor analysis of metabolic syndrome among the middle‐aged Bengalee Hindu men of Calcutta, India

Factor analysis of metabolic syndrome among the middle‐aged Bengalee Hindu men of Calcutta, India

Normal Fasting Plasma Glucose and Risk of Prediabetes and Type 2 Diabetes: The Isfahan Diabetes Prevention Study

Effects of Gender and Height on the Oral Glucose Tolerance Test: The Isfahan Diabetes Prevention Study

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