Evaluation of the immunomodulatory and anti-inflammatory activity of Bakuchiol using RAW 264.7 macrophage cell lines and in animal models stimulated by lipopolysaccharide (LPS)

Kumar, Amit; Sawhney, Gifty; Nagar, Rakesh Kumar; Chauhan, Narendra Singh; Gupta, Nidhi; Kaul, Anpurna; Ahmed, Zabeer; Sangwan, Payare L.; Kumar, Parveen; Yadav, Govind

doi:10.1016/j.intimp.2020.107264

Cited by 21 publications

(10 citation statements)

References 28 publications

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“…Bakuchiol was also studied to elucidate its immunomodulatory and anti‐inflammatory mechanisms in macrophage cell lines, showing that it significantly suppressed the pro‐inflammatory cytokine expression in a dose‐dependent manner 18 . Also, oral administration per healthy mice significantly decreased delayed hypersensitivity responses as compared to control group 18 …”

Section: Resultsmentioning

confidence: 99%

“…17 Bakuchiol was also studied to elucidate its immunomodulatory and anti-inflammatory mechanisms in macrophage cell lines, showing that it significantly suppressed the pro-inflammatory cytokine expression in a dose-dependent manner. 18 Also, oral administration per healthy mice significantly decreased delayed hypersensitivity responses as compared to control group. 18 The antifungal activities of the resinous exudates from the plant P. glandulosa and of the two major meroterpenoids (3-hydroxy-BAK and BAK) isolated from this plant were assayed against several Candida species.…”

Section: Other Applicationsmentioning

confidence: 89%

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Applications of bakuchiol in dermatology: Systematic review of the literature

Puyana

Chandan

Tsoukas

2022

J of Cosmetic Dermatology

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Background Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with promising anti‐aging, anti‐inflammatory, and antibacterial properties. The trend for “clean” skincare products and search for anti‐aging retinoid alternatives have poised BAK as a “must‐have” ingredient in skincare. Aims Our aim was to review the data for the applications of BAK in dermatology. Methods This is a systematic review of PubMed. Results Thirty articles matched our search terms [“Bakuchiol” and “Dermatology”] or [“Bakuchiol” and “Skin”] of which one did not meet inclusion criteria, 16 were pre‐clinical studies, seven clinical studies, three commentaries, two narrative reviews, and one report on adverse events. BAK has been mostly studied for its effects on photoaging, acne, and post‐inflammatory hyperpigmentation (PIH), showing beneficial results comparable to those achieved by topical retinoids. While having no structural resemblance to retinoids, BAK can function as a retinol analog, through retinol‐like regulation of gene expression. In in vivo studies, BAK was used alone or in combination with other products resulting in a significant reduction in photodamage, hyperpigmentation, wrinkle scores, and acne severity. Additionally, in vitro studies hinted at its anti‐cancer properties by inhibiting epidermal growth factor induced neoplastic cell transformation. Also, demonstrated potential applications in psoriasis by normalizing keratinocyte activity and in pigmentary disorders through inhibition of melanogenesis. There was one adverse event case reported of contact dermatitis in the literature. Conclusions Bakuchiol is a retinol alternative with anti‐aging, antibacterial, and anti‐inflammatory properties. Additional studies are warranted to better understand its applications in dermatology.

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Section: Resultsmentioning

confidence: 99%

Section: Other Applicationsmentioning

confidence: 89%

Applications of bakuchiol in dermatology: Systematic review of the literature

Puyana

Chandan

Tsoukas

2022

J of Cosmetic Dermatology

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show abstract

“…Another example is bakuchiol, a meroterpene in the class of terpenophenol, and hinokitiol, a natural monoterpenoid. Bakuchiol has been demonstrated to be effective in the suppression of pro-inflammatory cytokine expression and mitigation of delayed hypersensitivity responses compared to the control group ( Kumar et al, 2021 ). Hinokitiol inhibits LPS-mediated regulation, including tumor necrosis factor-alpha, IL-6, and prostaglandin E2 (PGE2).…”

Section: Role Of Terpenes and Terpenoids On Human Healthmentioning

confidence: 99%

Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives

et al. 2022

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“…PAF's (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) unique structure offers further insights into its role in atherosclerosis. PAF is synthesized from a subclass of phosphatidyl-cholines, which contain an ether bond instead of an ester bond with the backbone of glycerol [20]. It is a minor component of low-density lipoprotein (LDL), which, along with platelets, is another key pro-atherogenic mediator [27].…”

Section: Paf Structure and Molecular Mechanismmentioning

confidence: 99%

The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging

et al. 2022

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Hypertension and atherosclerosis are debilitating diseases that affect millions each year. Long-term consequences include but are not limited to stroke, myocardial infarction, and kidney failure. Platelet-activating factor (PAF) is a proinflammatory mediator synthesized from a subclass of phosphatidylcholines that increases platelet activation, leukocyte adhesion, infiltration of macrophages, and intracellular lipid accumulation, thereby contributing to atherosclerosis. Magnesium, a key micronutrient and free radical scavenger, is a water-soluble mineral that regulates peripheral vasodilation and calcium, phosphate, and hydroxyapatite homeostasis. Magnesium’s antihypertensive ability stems from its role as a natural calcium antagonist and promoter of vasodilatory mediators, such as nitric oxide. Platelet-activating factor and magnesium share an inverse relationship, and elevated magnesium levels have been shown to have protective effects against plaque formation as well as antihypertensive and antiarrhythmic effects, all of which allow for healthier aging. The purpose of this literature review is to investigate the role of platelet-activating factor and magnesium in the pathophysiology of hypertension, atherosclerosis, cardiovascular disease, stroke, and aging. Since the pathophysiology of the platelet-activating factor biomolecule is underexplored, further research studies are warranted in order to navigate the putative signaling pathways involved in the cardioprotective effects of dietary magnesium as a natural anti-PAF agent.

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Evaluation of the immunomodulatory and anti-inflammatory activity of Bakuchiol using RAW 264.7 macrophage cell lines and in animal models stimulated by lipopolysaccharide (LPS)

Cited by 21 publications

References 28 publications

Applications of bakuchiol in dermatology: Systematic review of the literature

Applications of bakuchiol in dermatology: Systematic review of the literature

Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives

The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging

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