Evaluation of the effects of chronic occupational exposure to metallic mercury on the thyroid parenchyma and hormonal function

Correia, M. M.; Chammas, M.C.; Zavariz, Julia; Azuma, Arata; Martins, Lourdes Conceição; Marui, Suemi; Pereira, Leidiane Adriano

doi:10.1007/s00420-019-01499-0

Cited by 12 publications

(18 citation statements)

References 38 publications

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“…Likewise, an increase [ 458 , 468 , 476 , 477 ], a decrease [ 318 , 458 , 465 , 470 , 473 , 478 ] or no change [ 351 , 423 , 457 , 459 , 460 , 461 , 465 , 466 , 469 , 471 , 472 , 474 , 475 , 478 ] in T4 levels and an increase [ 351 , 423 , 458 , 468 , 477 ], a decrease [ 465 , 472 ] or no change [ 423 , 457 , 459 , 460 , 461 , 466 , 470 , 471 , 473 , 474 , 475 ] in T3 levels were observed after lead exposure. TSH levels were increased [ 479 , 480 ] or unchanged [ 318 , 423 , 456 , 457 , 481 , 482 ] after exposure to mercury. T4 levels were also increased [ 480 , 481 ], decreased […”

Section: Environmental Factors That Influence Tsh and Thyroid Hormone Levelsmentioning

confidence: 99%

“…TSH levels were increased [ 479 , 480 ] or unchanged [ 318 , 423 , 456 , 457 , 481 , 482 ] after exposure to mercury. T4 levels were also increased [ 480 , 481 ], decreased [ 456 , 457 , 480 , 482 ] or unchanged [ 351 , 423 , 456 , 457 , 479 ] after exposure to mercury. Inconsistent results for T3 were also observed: studies reported an increase [ 483 ], a decrease [ 456 , 457 , 481 , 482 ] or no change [ 479 ] after mercury exposure ( Table 2 ).…”

Section: Environmental Factors That Influence Tsh and Thyroid Hormone Levelsmentioning

confidence: 99%

“…T4 levels were also increased [ 480 , 481 ], decreased [ 456 , 457 , 480 , 482 ] or unchanged [ 351 , 423 , 456 , 457 , 479 ] after exposure to mercury. Inconsistent results for T3 were also observed: studies reported an increase [ 483 ], a decrease [ 456 , 457 , 481 , 482 ] or no change [ 479 ] after mercury exposure ( Table 2 ). The cause of variability between the studies was probably due to the fact that the participants were exposed to different doses of heavy metals.…”

Section: Environmental Factors That Influence Tsh and Thyroid Hormone Levelsmentioning

confidence: 99%

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Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Leko

Gunjača

Pleić

et al. 2021

IJMS

113

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Thyroid hormones are necessary for the normal functioning of physiological systems. Therefore, knowledge of any factor (whether genetic, environmental or intrinsic) that alters the levels of thyroid-stimulating hormone (TSH) and thyroid hormones is crucial. Genetic factors contribute up to 65% of interindividual variations in TSH and thyroid hormone levels, but many environmental factors can also affect thyroid function. This review discusses studies that have analyzed the impact of environmental factors on TSH and thyroid hormone levels in healthy adults. We included lifestyle factors (smoking, alcohol consumption, diet and exercise) and pollutants (chemicals and heavy metals). Many inconsistencies in the results have been observed between studies, making it difficult to draw a general conclusion about how a particular environmental factor influences TSH and thyroid hormone levels. However, lifestyle factors that showed the clearest association with TSH and thyroid hormones were smoking, body mass index (BMI) and iodine (micronutrient taken from the diet). Smoking mainly led to a decrease in TSH levels and an increase in triiodothyronine (T3) and thyroxine (T4) levels, while BMI levels were positively correlated with TSH and free T3 levels. Excess iodine led to an increase in TSH levels and a decrease in thyroid hormone levels. Among the pollutants analyzed, most studies observed a decrease in thyroid hormone levels after exposure to perchlorate. Future studies should continue to analyze the impact of environmental factors on thyroid function as they could contribute to understanding the complex background of gene–environment interactions underlying the pathology of thyroid diseases.

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Section: Environmental Factors That Influence Tsh and Thyroid Hormone Levelsmentioning

confidence: 99%

Section: Environmental Factors That Influence Tsh and Thyroid Hormone Levelsmentioning

confidence: 99%

Section: Environmental Factors That Influence Tsh and Thyroid Hormone Levelsmentioning

confidence: 99%

See 1 more Smart Citation

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Leko

Gunjača

Pleić

et al. 2021

IJMS

113

View full text Add to dashboard Cite

show abstract

“…The growing use of this metal in diverse areas of industry has resulted in a significant increase of environment contamination and episodes of human intoxication. Many experimental and occupational studies of Hg in different chemical states shown significant alterations in thyroid hormones metabolism and thyroid gland parenchyma [87,88]. Moreover, Hg was classified as certain or probable carcinogen by the International Agency for Research on Cancer [81].…”

Section: Mercurymentioning

confidence: 99%

Content of 31 trace elements in thyroid malignant nodules and thyroid tissue adjacent to nodules investigated using neutron activation analysis and inductively coupled plasma mass spectrometry

Zaichick¹

2022

World J. Adv. Res. Rev.

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Thyroid malignant nodules (TMNs) are the most common endocrine cancer and the fifth most frequently occurring type of malignancies. Women are at particular risk for this thyroid disease The etiology and pathogenesis of TMNs must be considered as multifactorial. The present study was performed to clarify the role of some trace elements (TEs) in the etiology of these thyroid disorders. Thyroid tissue levels of silver (Ag), aluminum (Al), boron (B),, beryllium (Be), bismuth (Bi), cadmium (Cd), cerium (Ce), cobalt (Co), chromium (Cr), cesium (Cs), iron (Fe), gallium (Ga), mercury (Hg), lanthanum (La), lithium (Li), manganese (Mn), molybdenum (Mo), neodymium (Nd), nickel (Ni), lead (Pb), praseodymium (Pr), rubidium (Rb), antimony (Sb), scandium (Sc), selenium (Se), samarium (Sm), tin (Sn), thallium (Tl), uranium (U), yttrium (Y), and zinc (Zn) were prospectively evaluated in malignant tumor and thyroid tissue adjacent to tumor of 41 patients with TMNs. Measurements were performed using a combination of non-destructive instrumental neutron activation analysis and destructive method such as inductively coupled plasma mass spectrometry. Results of the study were additionally compared with previously obtained data for the same TEs in “normal” thyroid tissue. It was observed that main characteristics of TMNs in comparison with “normal” thyroid were significantly elevated levels of Ag, Al, B, Bi, Ce, Cr, Hg, Mn, Mo, Ni, Pb, Rb, Sm, and Tl. Furthermore, the TEs composition of thyroid tissue adjacent to tumor did not equal TEs contents of “normal” thyroid. Moreover, contents of such elements as Ag, Hg, and Se in adjacent tissue were higher than in tumor. Thus, from results obtained, it was possible to conclude that at least the excessive accumulation of Ag, Hg, and Se by thyroid tissue is likely to precede the TMNs origination and development. Elevated levels of Ag, Al, B, Bi, Ce, Cr, Hg, Mn, Mo, Ni, Pb, Rb, Sm, and Tl in nodular tissue could possibly be explored for differential diagnosis of benign and malignant thyroid nodules.

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“…Metal toxicity is based on a number of direct or indirect effects in the intracellular environment. Induction of oxidative stress, deregulation of signaling pathways, interference with structural/fibrous keratin proteins, genotoxicity, changes in gene expression, and impaired intercellular communication are the most common mechanisms of trace metal toxicity (Malandrino et al 2020a, b;Memon et al 2016;Correia et al 2020). The extent and consequences of biological damage directly depend on exposure parameters, including physicochemical properties, dose, duration, bioavailability, and metal characteristics (Vigneri et al 2017).…”

Section: Trace Metals and Thyroid Cancerogenesismentioning

confidence: 99%

Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

Stojsavljević

Rovčanin

2021

Expo Health

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Most investigations conducted in the last four decades have shown a rising incidence of thyroid diseases worldwide. Although our knowledge of the molecular pathways of thyroid disease has advanced, the initial steps in thyroid cancerogenesis have not yet been sufficiently elucidated. However, recent human biomonitoring studies have shown that specific trace metals, as major endocrine disrupters, could be considered as risk factors for impaired thyroid health and the evolution of thyroid cancer (TC). In this review, the impact of essential and toxic trace metals from the environment on thyroid health and TC was evaluated. Furthermore, this review clarifies which trace metals most likely contribute to the etiology of TC. Biomarkers based on trace metal ratios are proposed. Overall, the information described in this review is expected to be useful in planning future fundamental and applied studies on the endocrine toxicity of essential and toxic trace metals.

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Evaluation of the effects of chronic occupational exposure to metallic mercury on the thyroid parenchyma and hormonal function

Cited by 12 publications

References 38 publications

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Content of 31 trace elements in thyroid malignant nodules and thyroid tissue adjacent to nodules investigated using neutron activation analysis and inductively coupled plasma mass spectrometry

Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

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