Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

Stojsavljević, Aleksandar; Rovčanin, Branislav

doi:10.1007/s12403-021-00406-8

Cited by 8 publications

(3 citation statements)

References 154 publications

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“…In addition to Cu, other essential trace elements such as selenium, cadmium, zinc were likely involved in the carcinogenesis of thyroid. 32 The expand study of multiple trace element levels and their ratios would give more informative data about the relation between trace elements and thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Serum Copper Levels in Patients with Papillary Thyroid Carcinoma, Nodular Goiter, and Healthy Volunteers

Maneeprasopchoke

Phousamran²,

Pongsapich³

et al. 2023

Siriraj Med J

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Objective: Serum copper (Cu) is an essential trace element that plays a key role in thyroid hormone production. An inappropriate level of serum Cu might be related to development of both benign and malignant thyroid neoplasm. Nodular goiter and papillary thyroid carcinoma (PTC) are common benign and malignant tumors of the thyroid, respectively. This study aims to compare the serum Cu levels of healthy women with women with PTC or nodular goiter.Materials and Methods: A total of 205 Thai women were recruited for this cross-sectional study. The reference group was comprised of 100 healthy volunteers. There were 61 nodular goiter and 41 PTC patients that had been treated with surgery. Serum Cu was measured using an atomic absorption spectrophotometer and the three groups were compared.Results: The serum Cu levels of the PTC, nodular goiter and the reference group were 0.93 (0.85, 1.11) μg/ml, 1.03 (0.90, 1.14) μg/ml and 0.97 (0.80, 1.11) μg/ml, respectively. The results were not statistically different (P = 0.10). A post hoc subgroup analysis in the PTC group showed only serum Cu levels were significantly higher in the blood vessel invasion group (P = 0.02).Conclusion: The serum Cu levels of patients with PTC and nodular goiter were not different and did not differ significantly from the reference group. Despite related to with only one pattern of histopathologically aggressive PTCBlood vessel invasion, serum Cu levels cannot be used as an assistive tool for diagnosis and the prognosis of PTC.

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Section: Discussionmentioning

confidence: 99%

A Comparison of Serum Copper Levels in Patients with Papillary Thyroid Carcinoma, Nodular Goiter, and Healthy Volunteers

Maneeprasopchoke

Phousamran²,

Pongsapich³

et al. 2023

Siriraj Med J

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“…Trace elements can act as major endocrine disrupters and therefore seem to be risk factors for impaired thyroid health and the evolution of thyroid cancer [ 16 ], immune function [ 17 ] or even metabolic syndrome and obesity [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Trace Elements in Portuguese Children: Urinary Levels and Exposure Predictors

Correia-Sá,

Fernandes,

Maia

et al. 2023

Toxics

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Exposure to environmental chemicals during developmental stages can result in several adverse outcomes. In this study, the exposure of Portuguese children to Cu, Co, I, Mo, Mn, Ni, As, Sb, Cd, Pb, Sn and Tl was evaluated through the analysis of first morning urine through ICP-MS. Furthermore, we attempted to determine possible exposure predictors. The study sample consisted of 54% girls and 46% boys, with a median age of 10 years; 61% were overweight/obese and were put on a nutritionally oriented diet. For I, half of the population was probably in deficiency status. The median urinary concentrations (μg/L) were Cu 21.9, Mo 54.6, Co 0.76, Mn 2.1, Ni 4.74, As 37.9, Sb 0.09, Cd 0.29, Pb 0.94, Sn 0.45, Tl 0.39 and I 125.5. The region was a significant predictor for Cu, Co, Ni, As and Tl. Children living in an urban area had higher urinary levels, except for Co and Ni. Age was a significant predictor for Cu, I, Mo, Mn, Ni, Sb, Cd and Sn with urinary levels of these elements decreasing with age. No sex-related differences were observed. Diet and weight group were predictors for urinary Cu, Mn, Ni, Sb and As. Significant differences were observed between the diet/weight groups for Cu, Ni, Sb and As, with the healthy diet group presenting higher values.

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“…Heavy metals have a long half-life, and ongoing exposure leads to their bioaccumulation in the body[e.g., cadmium (Cd) has a half-life of 10–30 years] ( 13 , 14 ). A disturbance in the delicate balance of essential nutrients can also negatively impact health ( 15 ). Consequently, essential and non-essential elements were linked with many adverse health effects, including low serum albumin levels ( 16 – 18 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing

Zhou

Mei

et al. 2022

Front. Nutr.

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Background & aimsFew epidemiological studies have investigated the relationships of urinary essential and non-essential elements with serum albumin, an indicator of nutritional status, especially for the elderly in China.MethodsA community-based study among elderly participants (n = 275) was conducted in Beijing from November to December 2016. We measured 15 urinary elements concentrations and serum albumin levels. Three statistical methods including the generalized linear model (GLM), quantile g-computation model (qgcomp) and bayesian kernel machine regression (BKMR) were adapted.ResultsIn GLM analysis, we observed decreased serum albumin levels associated with elevated urinary concentrations of aluminum, arsenic, barium, cobalt, chromium, copper, iron, manganese, selenium, strontium, and zinc. Compared with the lowest tertile, the highest tertile of cadmium and cesium was also negatively associated with serum albumin. Urinary selenium concentration had the most significant negative contribution (30.05%) in the qgcomp analysis. The negative correlations of element mixtures with serum albumin were also observed in BKMR analysis.ConclusionsOur findings suggested the negative associations of essential and non-essential elements with serum albumin among the elderly. Large-scare cohort studies among the general population are required to validate our findings and elucidate the relevant underlying mechanisms.

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Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

Cited by 8 publications

References 154 publications

A Comparison of Serum Copper Levels in Patients with Papillary Thyroid Carcinoma, Nodular Goiter, and Healthy Volunteers

A Comparison of Serum Copper Levels in Patients with Papillary Thyroid Carcinoma, Nodular Goiter, and Healthy Volunteers

Trace Elements in Portuguese Children: Urinary Levels and Exposure Predictors

The effect of urinary essential and non-essential elements on serum albumin: Evidence from a community-based study of the elderly in Beijing

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