Evaluation of the Effect of Aloe Vera Ointment with Chamomile Ointment on Severity of Children’s Diaper Dermatitis : A Randomized, Double-Blind Clinical Trial

Badelbuu, Sima Ghanipour; Javadzadeh, Yousef; Jabraeili, Mahnaz

doi:10.5742/mewfm.2018.93304

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Three studies (Adib-Hajbaghery et al, 18 Panahi et al, 19 and Badelbuu et al 20 ) analysed the treatment of diaper dermatitis with phytotherapy in a total of 215 children, aged from 0 to 3 years. All three studies were conducted in Iran, and all of them were randomized-controlled, double-blind trials.…”

Section: Diaper Dermatitismentioning

confidence: 99%

See 1 more Smart Citation

Phytotherapy in paediatric skin disorders – A systematic literature review

Kloter

Albanese

Schweighoffer

et al. 2023

Complementary Therapies in Medicine

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Section: Diaper Dermatitismentioning

confidence: 99%

“…According to the results, there was an improvement in the severity of dermatitis during the six-day study in all three groups, but no group was superior to another. 20 In all three studies, the treatments were described as safe without describing the process of side effect assessment in more detail.…”

Section: Diaper Dermatitismentioning

confidence: 99%

Phytotherapy in paediatric skin disorders – A systematic literature review

Kloter

Albanese

Schweighoffer

et al. 2023

Complementary Therapies in Medicine

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“…Skin irritation and the risk of maceration in diaper dermatitis cause a decrease in skin function. The parameters of the skin barrier assessment can be assessed by non-invasive methods; for diaper dermatitis, it can be assessed clinically with the degree of dermatitis from mild to severe, on a 5-point scale [9][10][11][12]. Therapy for diaper dermatitis can use zinc oxide for the prevention or treatment of moderate type of diaper dermatitis; For more severe diaper dermatitis, antifungal agents and low potency corticosteroids such as hydrocortisone are required.…”

Section: Introductionmentioning

confidence: 99%

Systematic Review and Meta-analysis of the Effectiveness of Topical Aloe vera on Diaper Dermatitis with Parameters Degree of Diaper Dermatitis with Scale

Atikasari¹,

Malik²,

Widayati³

et al. 2021

Dermatol Res

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Background: For toddlers younger than 36 months, most of them still use diapers, so diaper rashes frequently appear in the diaper area. To improve the skin barrier, a moisturizer is needed to repair the skin barrier. Besides, the ceramide gold standard of moisturizer for diaper dermatitis, topical ingredients with natural ingredients can be used, for example, topical Aloe vera. Objective: To prove the effectiveness of topical Aloe vera moisturizer compared to other topical ingredients against diaper dermatitis. Methods: The results of the electronic database search Medline Pubmed, Scopus, EBSCOhost, ProQuest, Cochrane library, ClinicalTrials.gov, found 5 articles were included in the qualitative review (n = 289 subjects) and 4 articles (n = 214 subjects) were included in the meta-analysis. Results: Meta-analysis showed that after the administration of topical Aloe vera, there was a mean difference in the score of the degree of diaper dermatitis before and after therapy, the result showed negative value in the studies which were included the treatment group with Aloe vera. This indicates a decrease in the degree of diaper dermatitis after treatment with Aloe vera. The control group also showed that the mean score difference in the degree of diaper dermatitis after administration of control therapy was all negative. This shows that after the administration of therapy in the control group there was also a decrease in the score of the degree of dermatitis. The biggest decrease in the degree of diaper dermatitis was in the study conducted by Murni 2020, which was -2.10 ± 1.39. The lowest decrease in the degree of diaper dermatitis was found in the study conducted by Badelbuu 2019 B which received Chamomile, which was -0.93 ± 1.08. Meanwhile, in the Panahi’s study, the heterogeneity test results showed the value of Q=5,324 df=43; p=0,256, I2=24,866. This shows that the data is homogeneous, it is in line with the results of the statistical Q test and heterogeneity, the results of the I2 test obtained p < 0.001 which also indicates the data is homogeneous. The analysis was carried out using a fixed effect model because the data were homogeneous. The results of the meta-analysis showed that the statistical Q value was z value = -0.969 (p = 0.047). It has quite meaningful results. Conclusion: The meta-analysis showed that statistically there were only slight differences, but there were also studies that provided significant results. Topical application of Aloe vera appears to be more effective. The results of qualitative analysis on other skin barrier function parameters indicate that topical Aloe vera can improve skin barrier function in diaper dermatitis patients. In addition, it provides the same results as standard therapy and several other topical therapies that had been studied which had a good effect on repairing the skin barrier.

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“…In ITM textbooks, herbal oils such as pumpkin (Cucurbita pepo L.) seed oil and chamomile (Matricaria chamomilla L.) oil (aqueous chamomile extract in sesame oil vehicle) are recommended for topical management of psoriasis 13 . The therapeutic effects of topical chamomile on inflammatory skin conditions such as atopic eczema 14 , diaper rash 15,16 radiation dermatitis 17 and phlebitis 18 have been documented in several studies. However, studies on the topical dosage forms of pumpkin seeds are limited.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the efficacy of a topical chamomile-pumpkin oleogel for the treatment of plaque psoriasis: an intra-patient, double-blind, randomized clinical trial

et al. 2018

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Background: Plaque psoriasis is a chronic inflammatory skin disease. Conventional treatments of psoriasis are not completely effective. In addition, unwanted side effects limit their long-term use. In this regard, developing new natural treatments with fewer side effects could be an alternative option. This study was designed to evaluate the efficacy and safety of topical chamomile-pumpkin oleogel (ChP) in treating plaque psoriasis. Methods: A total of 40 patients with mild-to-moderate plaque psoriasis were enrolled in this intra-patient, double-blind, block-randomized clinical trial. In each patient, bilateral symmetrical plaques were treated with ChP or placebo twice daily for four weeks. For clinical assessment, the Psoriasis Severity Index (PSI) and the Physician's Global Assessment (PGA) scale were evaluated at baseline and after the treatment. At the end of the study, patients' satisfaction with the treatment was evaluated using a visual analog scale (VAS) ranging from 0 to 10. For safety assessment, all treatment-related side effects were recorded. Results: Thirty-seven subjects (20 female, 17 male; age 20–60 years) completed the study. The mean decreases in the PSI score in the ChP group (4.09 +/- 2.24) were significantly (p = 0.000) greater than the placebo group (0.48 +/- 1.39). According to the PGA results, 13/37 (35%) of the ChP-treated plaques could achieve marked to complete improvement compared to 0% in the placebo group. Three patients dropped out from the study due to worsening of bilateral plaques during the first week of trial. Conclusion: Our results suggest that topically applied ChP could provide a safe and effective complementary option for psoriasis plaque management. IRCT registration code: IRCT2016092830030N1.

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Evaluation of the Effect of Aloe Vera Ointment with Chamomile Ointment on Severity of Children’s Diaper Dermatitis : A Randomized, Double-Blind Clinical Trial

Cited by 4 publications

References 3 publications

Phytotherapy in paediatric skin disorders – A systematic literature review

Phytotherapy in paediatric skin disorders – A systematic literature review

Systematic Review and Meta-analysis of the Effectiveness of Topical Aloe vera on Diaper Dermatitis with Parameters Degree of Diaper Dermatitis with Scale

Evaluation of the efficacy of a topical chamomile-pumpkin oleogel for the treatment of plaque psoriasis: an intra-patient, double-blind, randomized clinical trial

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