Evaluation of the developmental toxicity of crocetin on Xenopus

Martin, G. Saint; Goh, Edward H.; Neff, Anton W.

doi:10.1016/s0278-6915(02)00040-6

Cited by 47 publications

(24 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4). Crocetin is considered a safer alternative to treat all-trans retinoic acids (ATRA) sensitive cancers in women of childbearing age [20]. Crocin, the gentiobiose diester of crocetin, was tested for treatment of adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol

et al. 2015

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol

et al. 2015

View full text Add to dashboard Cite

“…Some reports suggest that saffron is fully nontoxic herb (Abdullaev et al, 2003;Abdullaev and Espinosa-Aguirre, 2004). Contrasting this it has been specified that krustyn has some teratogenic impacts (Martin et al, 2002). Regarding toxic effects of saffron, its extract has been recognized fairly toxic (Loomis and Hayes, 1996).…”

Section: Introductionmentioning

confidence: 99%

Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

2011

American Journal of Animal and Veterinary Sciences

View full text Add to dashboard Cite

Problem statement: Saffron is widely used as a food flavor and has well known medicinal effects. This drug has an effect on steroid and sexual hormones. The aim of this study was investigation of Saffron orally administration on histomorphometric change of testicular tissue in rat. In this experimental study, 40 male rats are used (4 groups and 10 rats in each group). Approach: Animals were received Saffron (50, 100 and 200 mg kg −1 ) daily orally administration, during 28 days. As one group was control (normal saline) and three groups was drug consumer. The testis tissue was sampled after passing of above time and section providing, was stained by H and E. Results: The histomorphometric changes of testicular tissue which include, seminiferous tubules diameter, seminiferous epithelial thickness, interstitial tissue and testicular capsule thickness were studied. Results showed that seminiferous tubules diameter, seminiferous epithelial thickness had significantly decreased (p<0.05) but interstitial tissue thickness had significantly increased (p<0.05) compared with control group. Testicular capsule thickness had not significantly changed. Conclusion: Our results showed that seminiferous tubules diameter, seminiferous epithelial thickness and interstitial tissue thickness in rat testis were significantly changed after Saffron orally administration. This results probably via the reducing of serum testosterone concentration. Effect of Saffron on spermatogenesis index and unfertilization in human needed to be more investigation.

show abstract

“…: 0.075 and 0.225 ml/kg) disrupted skeleton formation as well as adversely affected in the weight, length, growth, mandible and calvaria of fetuses in mice (Moallem et al 2013). Crocetin (10 -200 μM) was found to exert a teratogenic effect in frog (Xenopus) embryos, where a decreased in head-to-tail length and eye diameters was observed (Martin et al 2002). Saffron is also evident to exert comutagenicity with BP (benzo[a]-pyrene) and 2AA (2-aminoantracene) in Salmonella typhimurium (Abdullaev et al 2003).…”

Section: Toxicological Effects Of Saffron and Its Derivativesmentioning

confidence: 99%

Both sides of the saffronâ€™s coin

Islam

2017

IJM

View full text Add to dashboard Cite

Saffron (Crocus sativus L.), a popular traditionally-used compound is known for its promising beneficial health effects. However, it has been reported to have a number of toxic effects in human and other animals. This paper aims to summarize saffron's beneficial and toxic effects. The findings suggest that sufficient precautions are needed in using saffron and its constituents as they have both beneficial and toxicological impacts on human.

show abstract

Evaluation of the developmental toxicity of crocetin on Xenopus

Cited by 47 publications

References 11 publications

Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol

Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol

Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

Both sides of the saffronâ€™s coin

Contact Info

Product

Resources

About