Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

T.,

doi:10.3844/ajavsp.2011.153.159

Cited by 3 publications

(2 citation statements)

References 32 publications

(59 reference statements)

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“…(a) Significant values versus group control, (b) Significant values versus AZP group cytoplasmic vacuolations was further reported by Karawya and ElNahas [62]. The current study noticed a decrease in the diameters of the seminiferous tubules which was proved by the morphometrical studies and agrees with the results of Shrestha et al and Khayatnouri et al [63,64]. Many cells appeared shrieked with pyknotic nuclei and deeply acidophilic cytoplasm, which may indicate apoptosis.…”

Section: Discussionsupporting

confidence: 90%

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Ramadan¹,

Schaalan²,

Mahmoud³

2018

J Steroids Horm Sci

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Section: Discussionsupporting

confidence: 90%

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Ramadan¹,

Schaalan²,

Mahmoud³

2018

J Steroids Horm Sci

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“…For microscopic examination, two types of slides with H&E and Masson's trichrome staining were prepared from testicular tissue samples. The tissue of the testis and epididymis was examined for any edema, hyperemia, and disruption of cellular order in a toxic tube, and the epididymis for fibrosis and loose connective tissue, and for the presence of sperm inside the tube [16].…”

Section: Measurement Of Malondialdehyde and Total Antioxidantmentioning

confidence: 99%

The Effect of Thyme Honey on the Histopathological Changes of the Testis in Relation to the Side Effects of Valproic Acid in Adult Male Wistar Rats

Safarian,

Shakib,

Rajabzadeh

et al. 2023

Andrologia

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Introduction. Valproic acid (VPA) is a widely used drug in the treatment of emotional and nervous depression, mental imbalances, epilepsy, and control of bipolar disorders. Despite its therapeutic effects, VPA has toxic effects on male reproduction. The testis is an organ sensitive to oxidative stress. On the other hand, thyme honey contains antioxidant compounds. The aim of this study was to investigate the effect of thyme honey on the histopathological changes of the testis in relation to the side effects of VPA in adult male Wistar rats. Methods. In this study, 48 Wistar rats were used, which were randomly divided into equal eight groups and received their desired substances. Including the control group, Th1, Th2, and Th3 groups receiving 1, 2, and 3 g/kg of thyme honey, respectively, VPA (500 mg/kg), VPA + Th1 (500 mg/kg of VPA + 1 g/kg of thyme honey), VPA + Th2 (500 mg/kg of VPA + 2 g/kg of thyme honey), and VPA + Th3 (500 mg/kg of VPA + 3 g/kg of thyme honey). After 60 days, evaluation of malondialdehyde (MDA), total antioxidant capacity (TAC), and histological studies of hematoxylin-eosin and Masson’s trichrome staining were performed. Results. The use of thyme honey significantly improved some parameters related to spermatogenesis, and in addition, it increased sperm production in the honey groups. In addition, the changes in MDA levels in the groups have shown a decrease in the amount of lipid peroxidation in the VPA + Th2 group. The amount of TAC also increased after increasing the dose of thyme honey. Conclusion. Based on the results of this study, it seems that thyme honey has been able to reduce the side effects of VPA to some extent due to its high percentage of antioxidants.

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Ameliorative effect of taurine-chloramine in azathioprine-induced testicular damage; a deeper insight into the mechanism of protection

Schaalan

Ramadan

Elwahab

2018

BMC Complement Altern Med

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BackgroundThe male reproductive system is a sensitive and intricate process that can be distressed following exposure to various toxicants. Therapeutic drugs, especially chemotherapeutics, can also adversely affect male fertility by instigating hormonal changes leading to testicular cells injury. Azathioprine (AZA) is an effective anticancer drug, but some cases of testicular toxicity have been reported. The aim of this work was to investigate the protective effects of taurine chloramine (TAU-Cl), a reported antioxidant and antiinflammtory peptide, against AZA-induced testicular dysfunction in male rats and ascertain the contributing mechanisms.MethodsForty male rats were allocated into four equal groups; (i) normal control rats, (ii) TAU-Cl group (100 mg/kg b.w/day for 10 weeks, (iii) AZA group (5 mg/day for 4 weeks); (iv) TAU-Cl/AZA group.ResultsAZA caused increased DNA damage in the testes, and alterations in sex hormones and sperm quality, including sperm count, viability, and motility. Moreover, testicular tissue from the AZA-treated group had increased levels of oxidative stress indicator, MDA, and decreased activity of the antioxidant enzymes as superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) levels. These deleterious events were accompanied by upregulated levels of the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α), and protein expression of iNOS and NFκB-p65, interleukin-1beta (IL-1β), and proapoptotic marker; caspase-9, together with decreased Bcl-2, NrF2 and hemeoxygenase (HO-1) expression. In contrast, TAU-Cl pretreatment significantly abrogated these toxic effects which were confirmed histologically.ConclusionPretreatment with TAU-Cl exerts a protective effect against AZA-induced male reproductive testicular atrophy. This finding could open new avenues for the use of TAU-Cl as a complementary approach to chemotherapy supportive care.

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Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

Cited by 3 publications

References 32 publications

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

The Effect of Thyme Honey on the Histopathological Changes of the Testis in Relation to the Side Effects of Valproic Acid in Adult Male Wistar Rats

Ameliorative effect of taurine-chloramine in azathioprine-induced testicular damage; a deeper insight into the mechanism of protection

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