Evaluation of the binder effects of the gum mucilages of Cissus populnea and Acassia senegal on the mechanical properties of paracetamol tablets

Abstract

A comparative study has been carried out to investigate the binder effects of the gums of Cissus populnea and Accasia senegal on the mechanical properties of paracetamol tablets. Tablet mechanical properties evaluated include the packing fraction (P f), the tensile strength (T) and the brittle fracture tendency (BFI). Varying concentrations of the gum mucilage ranging from 1-15% (w/v) was prepared and their relative viscosities determined. Each concentration was used to wet massed paracetamol powder to form granules. Tablets of paracetamol (500 ± 6.5 mg) were compressed at a constant compression load (7 arbitruary units on the scale). The tablets were equilibrated for 24 h before evaluation. At all binder concentrations A. senegal gum produced harder and more consolidated tablets than C. populnea as reflected by the higher T and P f values respectively. For instance, the T and P f values of the tablets at binder concentration of 10% (w/v) were 0.69 MNm-2 and 0.47 (A. senegal) and 0.57 MNm-2 and 0.23 (C. populnea), respectively. On the contrary, an increase in binder concentration generally resulted in a decrease in BFI values and this decrease was more marked with C. populnea. The study showed that A. senegal mucilage displayed better tableting characteristics and higher tendency for ameliorating capping tendency. Both mucilages have the potentials for substitution as binder for the more expensive starches in tablet formulation.

Formulation and <i>in vitro</i> evaluation of natural gum-based microbeads for delivery of Ibuprofen

“…Macbr, Family leguminosae, cissus gum, obtained from the stems and roots of Cissus pulpunae, Guill and Perr, Family Ampelidacae, and khaya gum, obtained from the incised trunk of Khaya grandifoliola CDC (Meliaceae), have been evaluated as potential carriers for controlled delivery of ibuprofen microbeads. The three natural gums have previously been characterized and found to be useful for controlled delivery of some drugs [9][10][11]. The main focus of the present study was the formulation of microbeads which will avoid the initial burst release which had previously been reported for ibuprofen using sodium alginate and other polymer blends [8].…”

Design of cissus–alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy

“…Cissus gum is a hydrophilic polysaccharide that swells rapidly in cold water and a 2% dispersion has been shown to attain a viscosity of 11.6 Pa s. It has a particle density of 1.59 g cm 3 and glass transition temperature of 264.2 • C [12]. The gum has been evaluated as a binder in pharmaceutical tablets where it was reported to produce tablets with high mechanical strength and slow drug release properties [15]. Cissus gum along with three other natural gums namely khaya, albizia and irvingia gums, has also been characterized and used, for the formulation of microbeads by ionic gelation method using zinc chloride as the chelating agent [12].…”

Tensile responses of treated <i>Cissus populnea</i> fibers

“…It is called food gum plant. Its sap had been used as soup thickener, for treatment of venereal diseases and indigestion [1,2], drug binder [3] and in ethnomedicine for treatment of male infertility [4]. About 51% of childless marriages result from fertility problems/sterility on the part of the male partners and demand the use of extract of the C. populnea plant [4].…”