Evaluation of the antidiarrheal activity of methanol leaf extract of Bombax Buonopozense in rats

Christain, Akuodor Godwin; Muazzam, I.; Idris-Usman, M. S.; Megwas, Anthony U.; Akpan, Joseph Linus; Chilaka, Kingsley Chimsorom; Okoroafor, Dorcas Okayo; Osunkwo, U. A.

doi:10.4103/1947-489x.210845

Cited by 44 publications

(32 citation statements)

References 15 publications

(14 reference statements)

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“…The methanolic leaf extract of Bombax buonopozense was found to possess antidiarrhoael, antinociceptic, anti-imflammatory, antipyretic and antimalarial activities. [24][25][26] The results obtained in the present study justify the use of the extracts of Bombax buonopozense leaves and roots in traditional medicine for the treatment of microbial disease, especially those caused by S. bioassay-guided fractionation and further characterization of the active constituents responsible for the antimicrobial potential of this medicinally important plant is under way in our laboratory.…”

Section: Discussionmentioning

confidence: 95%

Phytochemical and antimicrobial properties of the methanolic extracts of Bombax buonopozense leaf and root

et al. 2012

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Objective: The leaf and root of Bombax buonopozense which have some ethnomedicinal applications were subjected to phytochemical screening and antimicrobial activity against some disease causing microorganisms. Material & Methods:The phytochemical composition was evaluated using standard procedures. Susceptibility of these clinical isolates (Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonae, Proteus spp. and Escherichia coli) to the extracts was determined using the agar diffusion method.Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, terpenoids, steroids, phlobatannins, anthraquinones and carbohydrates (mostly in root). The root extract demonstrated antibacterial activity against all the organisms tested, while the leaf extract had activity on S. aureus and B. subtilis only. Conclusion:The findings indicate that the root extract contain the most active components which may be used to source antibiotic substances for possible treatment of bacterial infections.

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Section: Discussionmentioning

confidence: 95%

Phytochemical and antimicrobial properties of the methanolic extracts of Bombax buonopozense leaf and root

et al. 2012

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“…In our study, we have shown the experimental data for one dose (200 mg/kg) only, for both extracts. There are many reports on anti-diarrehal activity of plant extract using this dose level [24] . Loperamide, apart from regulating the gastrointestinal tract, is also reported to slow down transit in the intestine, reduce colon flow rates and consequently have any effect on colonic motility [25,26] .…”

Section: Discussionmentioning

confidence: 99%

Studies on the anti–diarrheal properties of leaf extract of Desmodium puchellum

Rahman

Barua

Islam

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…Thereafter, they were observed for 4 hours for the presence of diarrhea defined as watery (wet), unformed stool. (Akuodor et al, 2011).…”

Section: Antidiarrheal Activitymentioning

confidence: 99%

Pharmacological effects of Cnicus arvensis on the gastrointestinal system

Saqib

Hassan

Imran

et al. 2018

Bangladesh J Pharmacol

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The current study was conducted to screen the possible pharmacological activity of Cnicus arvensis on the gastrointestinal system. The methanolic extract exerted concentration-dependent (0.01–3.0 mg/mL) spasmolytic effect using isolated tissue preparations of rabbit jejunum and caused relaxation of K+(80 mM)-induced spastic contractions. There was non-parallel shift in Ca++ concentration response curves towards right at tissue bath concentrations of 0.3 and 1.0 mg/mL. The solvent-solvents fractionation revealed domination of spasmolytic effects in petroleum ether fraction as compared to aqueous fraction. The methanolic extract also found to reduce the retching in chicks at 150 mg/kg as compared to chlorpromazine. The methanolic crude extract also found to reduce the number of wet spots using castor oil-induced diarrhea in rat as compare to loperamide. Our results reflected the presence of Ca++ channel blocking activity in methanolic extract, thus rationalizing the medicinal use of C. arvensis in diarrhea and vomiting.

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Evaluation of the antidiarrheal activity of methanol leaf extract of Bombax Buonopozense in rats

Cited by 44 publications

References 15 publications

Phytochemical and antimicrobial properties of the methanolic extracts of <i>Bombax buonopozense</i> leaf and root

Phytochemical and antimicrobial properties of the methanolic extracts of <i>Bombax buonopozense</i> leaf and root

Studies on the anti–diarrheal properties of leaf extract of Desmodium puchellum

Pharmacological effects of Cnicus arvensis on the gastrointestinal system

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