Evaluation of the anti-fertility activity of stem bark of Crataeva nurvala buch-hum

Bhaskar, None; V, H; Profulla,; Kumar, Mukesh; BALAKRISHNAN, BALAKRISHNAN; B, R Balakrishnan; N,; Sangameswaran, None

doi:10.5897/ajb09.303

Cited by 28 publications

(23 citation statements)

References 9 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gumresin 625-1.25 gm, Emmenagogue and abortifacient effects. 13,16 Crataeva narvala , Tapia, Barna / Varuna, barun, possesses anti fertility activity dosage 20-30gm for100ml of decoction dose is 60 ml twice a day 22 Crocus sativus , Zafran / Kum kuma, Taken in high dose is toxic it may cause vomiting , uterine bleeding, bloody diarrhoea , beside stimulating the uterus , to be used with caution in pregnancy dosage:-0.25 to 1.5 gm/day, contraindicated during pregnancy 13,10 Croton tiglium Linn, Jamaalgotaa Agus/ Jayaopaala: drastic purgative contraindicated in pregnancy. TPA is carcinogenic Seed 25-50 mg 13 Datura Stramonium, Dhatura: Vigilant consideration is needed due to toxicity of plant, adverse effect in pregnancy can stimulate Uterine contraction and can cause miscarriage, 50-100mg dried leaf 12,23,13 Dorema ammonicum, Ammoniac Gum / Ushq: The drug is contraindicated during pregnancy due to the existence of indications of a menstruation-inducing effect Eucalyptus Globulas Labill, Nilgiri / Tailaparna: Not to be used internally in pregnancy internally undiluted fatal at 3.5 ml, study in rat shows eucalyptol is able to penetrate thweplacental tissue and reaches in concentration in fetal blood adequate for stimulating hepatic enzyme activity at dose 500 mg/kg S.C.…”

Section: 21mentioning

confidence: 99%

Use of Traditional Drugs in Pregnant and Nursing Mothers: A Review of Associated Adverse Drug Reactions

Hamiduddin¹,

Aslam²,

Sofi³

et al. 2016

J. Pharm. Sci. Innov.

View full text Add to dashboard Cite

The condition of carrying a developing embryo in the uterus and breast feeding of baby by mothers requires special precautions in term of intake of medicines. Usage of traditional drugs also requires some vigilance in respects of its adverse drugs reactions. The particular dangers of these preparations come rather from the belief that they are natural and therefore necessarily safe in pregnancy. Since last few decades' tremendous research work has been done of the various aspect of medicinal plants on pharmacognostic and chemical aspect, but aspect of safety and toxicity particularly, in pregnancy and lactation, is the most neglected area. These medicines are considering safer then allopathic drugs, but several plant species are proven be toxic in these conditions. For example, volatile oil containing drugs can be abortifacient, Irritant to genitourinary tract (can cause uterine contractions). Some constituents also have got action on uterus. Pyrrolizidine alkaloids can cause Hepatotoxicity in a new born. Some are strong diuretic and laxative (can cause water / salt lose), hormonally active, mutagenic, ginotoxic, teratogenic, etc. So these drugs are better avoided during pregnancy and lactations. An attempt can be made to identify herbal / traditional ingredients that have potential toxic effect on pregnancy and lactating women and also about their potential interfere with specific categories of conventional drugs based on their phytochemical, pharmacological properties and many documented side effects and also due to adulteration by heavy metals & microbial contaminations in relevance with classical Unani & Ayurvedic / traditional literature. Details of these drugs will be discussed in the present work.

show abstract

Section: 21mentioning

confidence: 99%

Use of Traditional Drugs in Pregnant and Nursing Mothers: A Review of Associated Adverse Drug Reactions

Hamiduddin¹,

Aslam²,

Sofi³

et al. 2016

J. Pharm. Sci. Innov.

View full text Add to dashboard Cite

show abstract

“…It has showed antioxidant activity [12,13], cardioprotective effect [14], chemo-preventive, and chemotherapeutic potentiality [15]. Moreover, the crude extract of bark exhibited antidiabetic [16], antidiarrhoeal [17], antifertility [18], and analgesic activity [19]. On the other hand, antidiarrhoeal, analgesic, and diuretic activities have proven for the leaves extract of this plant [20].…”

Section: Introductionmentioning

confidence: 99%

Potentiality of Crataeva nurvala bark in the management of thrombosis and membrane stabilization in the rural area, Bangladesh.

Uddin¹,

Laboni²,

Karim³

et al. 2018

Appl Med Res

View full text Add to dashboard Cite

Aim: Crataeva nurvala (C. nurvala) is a medicinally active plant, potentially used as traditional means of treating many health ailments such as prostatitis, prostate enlargement, inflammatory conditions, heart disease, thyroid and endocrine disorder, and urinary tract infection, respectively, in the rural region of Tangail, Jamalpur, Sherpur, and Barishal district since primitive era. In our concurrent research, the bark of this plant was undertaken in order to justify its folkloric history of thrombolytic, membrane stabilizing activity in vitro model, and for the quantification of total phenol content. Methods: The concentrated methanol extract partitioned into different fractions showed different amount of yield like 18.2 g of petroleum ether, 13 g of carbon tetrachloride, 11.1 g of chloroform, and 9.9 g of aqueous, respectively, then all of the fractioned extracts were employed to investigate folkloric uses of thrombolytic and membrane stabilizing potential in vitro models. Results: In the extrapolation of thrombolytic assay, petroleum ether fractioned exhibit the highest percent of clot lysis (27.36% ± 0.10%) activity compared with other fractioned and extract. Crude methanolic extract profoundly inhibited the breakdown of erythrocytes membrane (65.79% ± 0.40%)-induced by hypnotic solution and heat. On the other hand, acetylsalicylic acid (reference standard) resulted in 83.147% ± 0.39% inhibition of clot lysis. Alternatively, aqueous soluble fraction exposed slightly higher level of membrane stabilizing activity provoked by heat-induced hemolysis (75.3 ± 0.39). Conclusions:The present study was investigated to confirm the medicinal value of C. nurvala bark as a thrombolytic and membrane stabilizing agent. ARTICLE HISTORY

show abstract

“…Lupeol is a constituent of C. nurvala bark which showed antioxidant [11,12], cardio-protective [13], chemopreventive and chemotherapeutic properties [14]. The bark part also exhibited antidiabetic [15], antidiarrhoeal [16], antifertility [17], and analgesic properties [18]. The leaves of this plant have antidiarrhoeal, analgesic and diuretic activities [19].…”

Section: Introductionmentioning

confidence: 99%

In vivo hypoglycemic, antinociceptive and in vitro antioxidant activities of methanolic bark extract of Crataeva nurvala

Uddin¹,

Karim²,

Dwigbijoy³

et al. 2017

JCLM

View full text Add to dashboard Cite

Evaluation of the anti-fertility activity of stem bark of Crataeva nurvala buch-hum

Cited by 28 publications

References 9 publications

Use of Traditional Drugs in Pregnant and Nursing Mothers: A Review of Associated Adverse Drug Reactions

Use of Traditional Drugs in Pregnant and Nursing Mothers: A Review of Associated Adverse Drug Reactions

Potentiality of Crataeva nurvala bark in the management of thrombosis and membrane stabilization in the rural area, Bangladesh.

In vivo hypoglycemic, antinociceptive and in vitro antioxidant activities of methanolic bark extract of Crataeva nurvala

Contact Info

Product

Resources

About