Evaluation of Tests Used to Screen Patients With Liver Disorders

Scheig, Robert

doi:10.1016/s0095-4543(05)70347-x

Cited by 51 publications

(32 citation statements)

References 8 publications

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“…As a different point of view, Scheig 6 reported that the prothrombin time and serum albumin level are excellent measures of hepatic protein synthesis ability, whereas the bilirubin level is probably the best marker of overall liver function. Khan et al, 10 reported jaundice as a main predictor of severe liver injury in 36% of typhoid fever.…”

Section: Discussionmentioning

confidence: 99%

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Typhoid myopathy or typhoid hepatitis: A matter of debate

Mirsadraee¹,

Shirdel²,

Roknee³

2007

Indian J Med Microbiol

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Section: Discussionmentioning

confidence: 99%

“…AST and LDH are elevated in myopathy as well as hepatitis, whereas ALT and CK are relatively speciÞ c for liver and muscle, respectively. 6 According to the original deÞ nition of typhoid hepatitis, it is possible that an overdiagnosis for typhoid hepatitis occurred and typhoid myopathy was missed.…”

Section: Membersmentioning

confidence: 99%

Typhoid myopathy or typhoid hepatitis: A matter of debate

Mirsadraee¹,

Shirdel²,

Roknee³

2007

Indian J Med Microbiol

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“…Progressive prolongation of PT in cirrhotic patients closely relates to the severity of liver cirrhosis [8,11,[17][18][19]. The PT has kept its place not only as a useful routine screening test for the coagulation defects in liver disease [20,21], but also as the best guide to prognosis [13].…”

Section: Discussionmentioning

confidence: 99%

Haemostatic abnormalities in liver disease: could some haemostatic tests be useful as liver function tests?

Ghumlas

Gader

Faleh

2005

Blood Coagulation &Amp; Fibrinolysis

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The liver plays a central role in haemostasis, being the site of synthesis of most of the clotting factors, coagulation inhibitors and fibrinolytic parameters, in addition to its clearance of activated clotting and fibrinolytic factors. Nonetheless, no haemostatic test(s) is included among the routine liver function tests and this study aims to probe this possibility. The liver disease group (n=258) included acute hepatitis (n=25), chronic viral hepatitis (n=128), hepatitis B (HB) carriers (n=25), liver cirrhosis (n=67), and hepatocellular carcinoma (HCC) (n=13). The prothrombin time was significantly prolonged in acute hepatitis, liver cirrhosis and HCC. However, the reptilase time was prolonged in all the groups except in HB carriers, while the thrombin time was prolonged only in the HCC group. Antithrombin III and protein C levels exhibited significant reduction in acute hepatitis, liver cirrhosis and HCC. On the other hand, protein S levels (total and free) were reduced significantly in all the patients groups, including HB carriers when compared with healthy controls. Derangement of haemostatic tests is a common feature in liver disease, being most significant in acute hepatitis, liver cirrhosis and hepatocellular carcinoma. The most sensitive markers of hepatocyte malfunction are protein S (total and free) and the reptilase time as they were abnormal, in the mildest liver affections, when other biochemical tests as well as other haemostatic tests were normal. Further studies are needed to see whether these two tests qualify for inclusion among the routine liver function tests.

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“…Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are among the main routine laboratory tests used in screening for liver disease (Scheig 1996), and serum creatinine is the clinical biomarker of kidney function (Rubin et al 2007), which can increase in response to higher protein intake (Shemesh et al 1985). Furthermore, alkaline phosphatase (ALP) plasma levels are an important predictor of liver injury and also seem to be elevated in individuals on long-term creatine and WP supplementation (Whitt et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of resistance training associated with whey protein supplementation on liver and kidney biomarkers in rats

Nunes

Silva

Alves

et al. 2013

Appl. Physiol. Nutr. Metab.

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The aim of this study was to investigate the impact of whey protein (WP) supplementation and resistance training (RT) on liver and kidney biomarkers. The sedentary + WP group showed higher levels of plasma liver and kidney dysfunction markers compared with the other groups. In addition, WP supplementation associated with RT resulted in physiologic cardiac hypertrophy. WP supplementation without RT affected liver and kidney function.

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Evaluation of Tests Used to Screen Patients With Liver Disorders

Cited by 51 publications

References 8 publications

Typhoid myopathy or typhoid hepatitis: A matter of debate

Typhoid myopathy or typhoid hepatitis: A matter of debate

Haemostatic abnormalities in liver disease: could some haemostatic tests be useful as liver function tests?

Effects of resistance training associated with whey protein supplementation on liver and kidney biomarkers in rats

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