Typhoid myopathy or typhoid hepatitis: A matter of debate

Mirsadraee, Majid; Shirdel, Abbas; Roknee, F

doi:10.4103/0255-0857.37337

Cited by 14 publications

(12 citation statements)

References 8 publications

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“…The significant increase in EROD activity, MDA content and the significant decrease in GST activity in liver further demonstrated that liver, as the significant metabolite site, is the central organ that plays a pivotal role in activation and elimination of toxic xenobiotics [41,42]. In the present study, BaP-induced hepatotoxicity was also expressed as a significant increase in the activities of AST and CK and the IL-6 levels in serum as reported in other studies [43,44].…”

Section: Discussionsupporting

confidence: 88%

Benzo[a]pyrene Exposure Increases Toxic Biomarkers and Morphological Disorders in Mouse Cervix

Gao

Ying

et al. 2011

Basic &Amp; Clinical Pharmacology &Amp; Toxicology

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Benzo[a]pyrene (BaP) is a representative compound of polycyclic aromatic hydrocarbons exerting cytotoxicity and genotoxicity in the human liver, lung, stomach and skin. However, the toxic effect of BaP on cervical tissue remains unclear. This study was carried out to investigate the toxic effects of BaP on the cervix of ICR mice. Female mice were treated with BaP by intraperitoneal injection and oral gavage at a dose of 2.5, 5 and 10 mg ⁄ kg body-weight, twice a week for 14 weeks. BaP treatment caused a significant increase in the levels of MDA and IL-6 with significantly increased activity of CYP1A1, creatine kinase and aspartate aminotransferase (AST) and decreased activity of glutathione-S-transferase in the cervix and liver. The relative cervix weight was markedly reduced in the intraperitoneal BaP injection groups, whereas only a slight reduction was observed in the oral gavage groups. The increase in weight decreased with increasing BaP dose. Moreover, BaP treatment induced significant pathomorphological changes in the cervical tissue and increased the mortality of the mice. Taken together, these results suggest that BaP causes a certain toxic effect on cervical tissue.

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Section: Discussionsupporting

confidence: 88%

Benzo[a]pyrene Exposure Increases Toxic Biomarkers and Morphological Disorders in Mouse Cervix

Gao

Ying

et al. 2011

Basic &Amp; Clinical Pharmacology &Amp; Toxicology

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“…This study examined the effect of typhoid fever on some biochemical and hematological indices. Table ( fever [20], the frequency of elevated serum enzyme was 52%, 100% and 22% [21] respectively. The level of CK for patients (83.0±23.1Mmol/L) compared with control (84.3±18Mmol/L) indicates no significant increase.…”

Section: Resultsmentioning

confidence: 99%

“…The level of CK for patients (83.0±23.1Mmol/L) compared with control (84.3±18Mmol/L) indicates no significant increase. The incidence of cardiac involvement in typhoid is variable [21][22], Myopathy can cause severe myoglobinuria and elevated CK was found in 60% of typhoid fever patients [21]. Table ( and bone marrow suppression [4].…”

Section: Resultsmentioning

confidence: 99%

A study of the Biochemical and Haematological parameters in Patients of Typhoid Fever

Alrazaq¹,

Ali²

2017

djps

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“…26% and 20% by Mirsadraee et al, and Bhutta ZA respectively. 21,22 Hematological changes are common in typhoid fever. Significant changes include anemia, leucopoenia and thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

Study on ultrasound observations in children with typhoid fever in a tertiary care hospital

Ahamed¹,

Belavadi

2020

Int J Contemp Pediatr

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Background: Enteric fever continues to be endemic in poor countries globally, although it has been eradicated from the developed nations due to their well-organized sanitation and protected water supply. The five Fs most concerned with spread of typhoid disease are fingers, food, fomites, flies, and feces. Enteric fever is predominantly caused by Salmonella typhi and next in frequency is Salmonella paratyphi. Very less literature is available on radiological manifestations of typhoid fever in children on the basis of age difference in India. Hence, a study was conducted to observe the radiological findings and to correlate with laboratory manifestations in typhoid fever. Objectives of the study was to observe the ultrasound abdomen changes in Typhoid fever at rural area.Methods: The current study was conducted at Department of pediatrics of Narayana Medical College Hospital, Nellore, Andhra Pradesh state in a period of one year. All patients presenting with fever having positive for Widal test were included. In total 50 patients were included and divided into 2 age groups, <5 years and >5years. The laboratory results and abdominal ultrasound were conducted in the two groups and compared.Results: Total 20 patients in <5 years age and 30 patients in >5 years were enrolled. Male to female ratio was 2:1 in both groups. Common laboratory findings showed 32 patients (64%) with Anemia, elevated liver enzymes in 40 patients (80%), and elevated ESR in 42 patients (84%). 45 patients have Splenomegaly and hepatomegaly with normal parenchymal echotexture. Gallbladder sludge and biliary sludge was seen in 6 patients. Thickened gall bladder in 34 patients (68%) was observed. Bowel wall thickening seen in 32 patients (64%). mesenteric lymphadenopathy in 36 patients (68%) observed. All were recovered by treatment.Conclusions: On ultrasound, splenomegaly, hepatomegaly, and thick-walled gallbladder were observed in most of the childrens with typhoid fever. Therefore, ultrasound can also be used as supportive diagnose along with laboratory parameters due to it is a non-invasive and economical tool of diagnosing typhoid.

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Typhoid myopathy or typhoid hepatitis: A matter of debate

Cited by 14 publications

References 8 publications

Benzo[a]pyrene Exposure Increases Toxic Biomarkers and Morphological Disorders in Mouse Cervix

Benzo[a]pyrene Exposure Increases Toxic Biomarkers and Morphological Disorders in Mouse Cervix

A study of the Biochemical and Haematological parameters in Patients of Typhoid Fever

Study on ultrasound observations in children with typhoid fever in a tertiary care hospital

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