Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses

Abstract

Peritonitis in horses persists with high incidence and mortality, requiring more innovative and effective therapeutic strategies. The aim of this study was to evaluate Tenckhoff catheters and intraperitoneal use of ceftriaxone in horses. Ten healthy, male horses, with an average age of 5 years, were used and divided into two groups of five animals each. A Tenckhoff catheter was implanted in both groups. The intraperitoneal group received 25 mg/kg of ceftriaxone diluted in 1 L of 0.9% saline solution (SS) intraperitoneally via the Tenckhoff catheter, and the intravenous group received 25 mg/kg of ceftriaxone intravenously and 1 L of SS intraperitoneally. In both groups, the dosing interval was every 24 hours for 5 days. The animals were evaluated clinically and with laboratory tests through a blood count and plasma fibrinogen assay. A macroscopic, physical-chemical, and cytological evaluation of the peritoneal fluid and an abdominal sonographic evaluation were conducted before the catheter implantation and at 1, 3, 5, 7, and 10 days after the implantation and ceftriaxone administration. Seven days after the catheter insertion and the beginning of the intraperitoneal treatment, a laparoscopic evaluation was performed. The Tenckhoff catheter proved to be an appropriate route for intraperitoneal solution administration; however, it promoted a moderate inflammatory response in the abdomen. No differences in inflammatory reaction was observed between groups, suggesting that the intraperitoneal administration of the drug did not trigger a local or systemic inflammatory process, amplifying the possibilities of intraperitoneal route utilization in the treatment of peritonitis.

Adjuvant intraperitoneal ceftriaxone in the treatment of septic peritonitis in horses

“…The use of the Tenckhoff-type catheter for intraperitoneal administration of ceftriaxone in horses was described by Alonso et al 28 Here, intraperitoneal administrations were performed using the metallic guidewire of 14G venous catheters and no complications were observed while performing the procedure. The peritoneal fluid in 26.9 per cent (n=7/26) of the animals included in the study did not allow the evaluation of all inclusion criteria, and a cytological evaluation was prioritised.…”

Association of intraperitoneal ceftriaxone, intravenous gentamicin and oral metronidazole in the treatment of an abdominal abscess and peritonitis in a horse

“…The use of intraperitoneal route for ceftriaxone administration in horses has recently been described by Alonso et al (2017Alonso et al ( , 2018, and prolonged use of metronidazole without occurrence of adverse effects is reported as effective in abdominal abscesses treatment (Sweeney et al, 1991). The aim of this report is to describe a successful medical management of peritonitis and abdominal abscess with an association of intraperitoneal ceftriaxone, systemic gentamicin, and metronidazole.…”