Evaluation of surfactant cytotoxicity potential by primary cultures of ocular tissues: I. Characterization of rabbit corneal epithelial cells and initial injury and delayed toxicity studies

Grant, Roberta L.; Yao, Cheng; Gabaldon, Donna; Acosta, Daniel

doi:10.1016/0300-483x(92)90162-8

Cited by 123 publications

(62 citation statements)

References 41 publications

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“…It has been established that ionic surfactants exhibit higher cytotoxicity than the non ionic ones, and that cationic surfactants are more potent than their anionic counterparts. 42 This behavior has been observed using both in vivo and in vitro assays. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 The way in which hydrophobicity and cationic charge density affects toxicity against 3T3 cells and hemolytic activity is very different, because different mechanisms of action are evaluated.…”

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confidence: 91%

pH-Sensitive Surfactants from Lysine: Assessment of Their Cytotoxicity and Environmental Behavior

et al. 2012

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The toxicity and environmental behavior of new pH-sensitive surfactants from lysine are presented. Three different chemical structures are studied: surfactants with one amino acid and one alkyl chain, surfactants with two amino acids on the polar head and one alkyl chain, and gemini surfactants. The pH sensitivity of these compounds can be tuned by modifying their chemical structures. Cytotoxicity has been evaluated using erythrocytes and fibroblast cells. The toxic effects against these cells depend on the hydrophobicity of the molecules as well as their cationic charge density. The effect of hydrophobicity and cationic charge density on toxicity is different for each type of cells. For erythrocytes, the toxicity increases as hydrophobicity and charge density increases. Nevertheless, for fibroblasts cationic charge density affects cytotoxicity in the opposite way: the higher charge density, the lower the toxicity. The effect of the pH on hemolysis has been evaluated in detail. The aquatic toxicity was established using Daphnia magna. All surfactants yielded EC50 values considerably higher than that reported for cationic surfactants based on quaternary ammonium groups. Finally, their biodegradability was evaluated using the CO2 headspace test (ISO 14593). These lysine derivatives showed high levels of biodegradation under aerobic conditions and can be classified as “readily biodegradable compounds”.

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confidence: 91%

pH-Sensitive Surfactants from Lysine: Assessment of Their Cytotoxicity and Environmental Behavior

et al. 2012

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“…QACs, in general, are toxic to mammalian cells and are not recommended for systemic application (17), but are acceptable for topical application (mouthwash products, oral antiseptics). There are reports of damaging effects of cationic surfactants on human lymphocytes (18) (19). These adverse effects are avoided by the use of so-called soft analogues of long chain QACs.…”

Section: Cationic Surfactantsmentioning

confidence: 99%

Surfactants in the Environment

Ivanković

Hrenović

2010

Archives of Industrial Hygiene and Toxicology

308

181

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Surfactants in the EnvironmentSurfactants are a diverse group of chemicals that are best known for their wide use in detergents and other cleaning products. After use, residual surfactants are discharged into sewage systems or directly into surface waters, and most of them end up dispersed in different environmental compartments such as soil, water or sediment. The toxic effects of surfactants on various aquatic organisms are well known. In general, surfactants are present in the environment at levels below toxicity and in Croatia below the national limit. Most surfactants are readily biodegradable and their amount is greatly reduced with secondary treatment in wastewater treatment plants. The highest concern is the release of untreated wastewater or wastewater that has undergone primary treatment alone. The discharge of wastewater polluted with massive quantities of surfactants could have serious effects on the ecosystem. Future studies of surfactant toxicities and biodegradation are necessary to withdraw highly toxic and non-biodegradable compounds from commercial use and replace them with more environmentally friendly ones.

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“…The cytotoxicity order of surfactants on rabbit corneal epithelial cells was cationic>anionic= amphoteric>nonionic; however, Triton X-100 had a ranking similar to anionic surfactants (100). Poloxalene (30% polyethyleneoxide and 70% polypropylene oxide, MW 3000) inhibited neutral fat and cholesterol absorption in rabbits (101).…”

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confidence: 99%

Alkyl Ethoxylated and Alkylphenol Ethoxylated Nonionic Surfactants: Interaction with Bioactive Compounds and Biological Effects

Cserháti¹

1995

Environ Health Perspect

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Evaluation of surfactant cytotoxicity potential by primary cultures of ocular tissues: I. Characterization of rabbit corneal epithelial cells and initial injury and delayed toxicity studies

Cited by 123 publications

References 41 publications

pH-Sensitive Surfactants from Lysine: Assessment of Their Cytotoxicity and Environmental Behavior

pH-Sensitive Surfactants from Lysine: Assessment of Their Cytotoxicity and Environmental Behavior

Surfactants in the Environment

Alkyl Ethoxylated and Alkylphenol Ethoxylated Nonionic Surfactants: Interaction with Bioactive Compounds and Biological Effects

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