Evaluation of submucosal upper gastrointestinal tract lesions by endoscopic ultrasound

Boyce, Gregory A.; Sivak, Michael; Rösch, Thomas; Classen, Meinhard; Fleischer, David E.; Boyce, H. Worth; Lightdale, Charles J.; Botet, José; Hawes, Robert H.; Lehman, Glen A.

doi:10.1016/s0016-5107(91)70778-5

Cited by 149 publications

(66 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies determined the usefulness of images obtained by EUS for evaluation of SET (3,4,12,14,16) . However, a study conducted at a single tertiary care center, comparing the endoscopy and endosonography for evaluating patients with bulging gastrointestinal tract lesions has not been so far reported.…”

Section: Discussionmentioning

confidence: 99%

“…1 Divisão de Endoscopia e Ecoendoscopia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto; 2 Departamento de Endoscopia e Ecoendoscopia Digestiva, Hospital Nove de Julho, São Paulo; 3 Departamento de Patologia, Diagnóstika, São Paulo, SP, Brazil. Correpondence: Dr. José Celso Ardengh -Alameda dos Arapanés, 881 -cj.…”

Section: Introductionunclassified

See 1 more Smart Citation

Upper endoscopy versus endosonography in differential diagnosis of gastrointestinal bulging

Ardengh

Vaiciunas

Kemp

et al. 2011

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -The identification of a bulging covered by normal epithelium is a common finding during an upper gastrointestinal endoscopy. Objective -To compare the endoscopic and endosonography findings in the differential diagnosis of the gastrointestinal bulging (subepithelial tumor or extrinsic compression). Method -Patients referred by endosonography with bulging of upper gastrointestinal tract were studied retrospectively. The size, location, consistency and presumptive diagnosis were recorded at time of endoscopy and endosonography. Endosonography-guided fine-needle aspiration was proposed in case of uncertain diagnose to increase diagnostic sensitivity. Results -One hundred seventy-six patients (93 women) and mean age 62.5 years (10-87). One hundred fifty-three had subepithelial tumor and 23 had extrinsic compression as a final diagnosis. Endosonography had sensitivity, specificity and accuracy higher than those found by endoscopy for both diagnosis subepithelial tumor and extrinsic compression. Endoscopy and endosonography showed poor concordance (K = 0.13) for subepithelial tumor diagnosis and unsuitable agreement for diagnosis in extrinsic compression (K = 0.01). The endosonography-guided fine-needle aspiration had sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 75%, 72.4%, 80.5%, 65.6% and 74%, respectively. Conclusion -Endoscopy has high sensitivity and low specificity for subepithelial tumor and both are low for the extrinsic compression. Endoscopy is a good tool for diagnosis of the subepithelial tumors, but not to determine the cause of an extrinsic compression. The endosonography identifies the layer from which subepithelial tumor comes, obtain histological samples, and increasing the diagnostic accuracy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionunclassified

Upper endoscopy versus endosonography in differential diagnosis of gastrointestinal bulging

Ardengh

Vaiciunas

Kemp

et al. 2011

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

“…La ecografía evidencia una lesión sólida bien definida, hiperecogénica, homogénea, bordes nítidos, encapsulada y sin tractos fibrosos ni quísticos en su interior [7][8][9][10] . .…”

Section: Gist Con Diferenciación Lipomatosa O Un Lipoma Gástrico (Figunclassified

Lipoma gástrico gigante sintomático tratado con gastrectomía subtotal laparoscópica: caso clínico

R¹,

Briceño³

et al. 2013

Rev. méd. Chile

View full text Add to dashboard Cite

show abstract

“…However, the differentiation between benign and malignant myogenic tumors can be endosonographically difficult. Several criteria have been suggested to indicate malignancy including size (> 3 cm), irregular border and the presence of internal cystic spaces [25,29,30]. Surgical resection has classically been recommended for those lesions with suspicious features.…”

Section: Gastrointestinal Stromal Tumors (Gist)mentioning

confidence: 99%

Molecules and markers for endosonographers: What do we need to know and measure?

Al‐Haddad

Wallace²

2006

Endoscopy

View full text Add to dashboard Cite

IntroductionEndoscopic ultrasound (EUS) has become an indispensable tool for the diagnosis and staging for gastrointestinal and thoracic malignancies. Thanks to the safety and reliability of fine needle aspiration (FNA), this has become the method of choice for tissue acquisition from lymph nodes and tumors in various locations within the thoracic and abdominal cavities.In the recent years, EUS-FNA has offered a better understanding of the pathophysiology of cancer. Similar to the adenoma-carcinoma sequence, other cancers including pancreas, lung, and esophagus may follow a comparable multi-step process of carcinogenesis. A necessary component of these is the ability to go ªbeyond cytologyº to use fine needle aspirates to characterize the genomic and proteomic profiles of cancer and precancerous tissue. Molecular characterization of FNA samples: The basic conceptsAlthough DNA is relatively stable in excised tissue, proteins and particularly RNA are unstable and must be handled in special ways to preserve them for characterization. The first role of the endoscopist is to obtain and preserve tissue suitable for further molecular characterization. In the first part of this review, we will focus on these initial steps. The methods for genomic and proteomic analyses are beyond the scope of this article and interested readers are referred to recent reviews [1,2].RNA destroying-enzymes (RNAase enzymes) are very ubiquitous in the environment. Therefore, it is imperative to prevent rapid degradation of RNA in order to preserve fine needle aspirates for genomic studies. The simplest method to do this is through the use of RNAase inhibitor solutions such as RNA-later (Quagen Inc. Valencia Ca, USA) or RNA Stat 60 (RNA STAT-60 ; TEL-TEST, Friendswood, TX, USA). The needle aspirate can be quickly mixed with these reagents. In our laboratory, we immediately place the FNA sample into an eppendorf tube in a wet ice bath, centrifuge in a small desktop device in the EUS room (1000 RPM at 4 deg. C, 1 minute), remove the supernatant, and resuspend the cell pellet in RNA stat 60. If RNA stabilization is not available on-site, the aspirate can also be snap frozen in liquid nitrogen and stored (preferably at ±70 to ±80C) for later RNA stabilization. Every effort should be made to handle the specimen in an RNAase-free environment including clean gloves and a surface that has been cleaned with an RNAase inhibitor solution.In the remainder part of this review, we will focus on organspecific applications of the biological markers. This will include lesions of the pancreas and gastrointestinal stromal tumors (GIST). The use of biomarkers in staging non-small call lung cancer will be discussed in a separate review. Pancreatic lesionsDiagnosis of early pancreatic cancer remains a challenge mainly due to the lack of a standard screening test. Therefore, improving long-term survival relies primarily on detecting and treating early pancreatic cancer and thus reducing the incidence of pancreatic cancer.EUS is increasingly considered a valuable to...

show abstract

Evaluation of submucosal upper gastrointestinal tract lesions by endoscopic ultrasound

Cited by 149 publications

References 13 publications

Upper endoscopy versus endosonography in differential diagnosis of gastrointestinal bulging

Upper endoscopy versus endosonography in differential diagnosis of gastrointestinal bulging

Lipoma gástrico gigante sintomático tratado con gastrectomía subtotal laparoscópica: caso clínico

Molecules and markers for endosonographers: What do we need to know and measure?

Contact Info

Product

Resources

About