Evaluation of stereotactic body radiotherapy (sbrt) boost in the management of endometrial cancer

Abstract

The purpose of this study is to evaluate the use of linear accelerator (LINAC)-based stereotactic body radiotherapy (SBRT) boost with multileaf collimator technique after pelvic radiotherapy (RT) in patients with endometrial cancer. Consecutive patients with endometrial cancer treated using LINAC-based SBRT boost after pelvic RT were enrolled in the study. All patients had undergone surgery including total abdominal hysterectomy and bilateral salpingo-oophorectomy ± pelvic/paraortic lymphadenectomy before RT. Prescribed external pelvic RT dose was 45 Gray (Gy) in 1.8 Gy daily fractions. All patients were treated with SBRT boost after pelvic RT. The prescribed SBRT boost dose to the upper two thirds of the vagina including the vaginal vault was 18 Gy delivered in 3 fractions with 1-week intervals. Gastrointestinal and genitourinary toxicity was assessed using the Common Terminology Criteria for Adverse Events version 3 (CTCAE v3).Between April 2010 and May 2011, 18 patients with stage I-III endometrial cancer were treated with LINAC-based SBRT boost after pelvic RT. At a median follow-up of 24 (8-26) months with magnetic resonance imaging (MRI) and gynecological examination, local control rate of the study group was 100 % with negligible acute and late toxicity.LINAC-based SBRT boost to the vaginal cuff is a feasible gynecological cancer treatment modality with excellent local control and minimal toxicity that may replace traditional brachytherapy boost in the management of endometrial cancer.

Evaluation of Radiosurgery Target Volume Determination for Meningiomas Based on Computed Tomography (CT) And Magnetic Resonance Imaging (MRI)

“…Stereotactic Body Radiation Therapy (SBRT) has emerged as a viable radiotherapeutic modality for management several benign and malign tumors throughout the human body including meningiomas, brain metastases, arteriovenous malformations, pituitary adenomas, vestibular schwannomas, cerebral cavernous malformations, craniopharyngiomas, glomus jugulare tumors, pulmonary oligometastases, and recurrent glioblastomas [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Evaluation of Treatment Outcomes of Early-Stage Endometrial Cancer Radiotherapy: A Single Center Experience

“…Ir-192 HDR brachytherapy was used between 2004 and2012 for 26 patients at a median total dose of 18 Gy in 3 fractions given weekly. Stereotactic Body Radiation Therapy (SBRT) was used in 23 patients for VCT at a median total dose of 18 Gy in 3 fractions given weekly and SBRT technique was reported in our previous study (Demiral et al, 2013). All patients with UPSC histology received chemotherapy.…”

Multimodality Imaging for Radiosurgical Management of Arteriovenous Malformations

“…In this context, microvascular surgical resection, endovascular embolization and radiosurgical treatment may be used for management of AVMs. Stereotactic Radiosurgery (SRS) has been utilized for management of several benign and malign indications with considerable success [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. In the context of AVMs, surgery offers effective management of AVMs in selected patients, however, radiosurgery may be considered when there may be an excessive risk of surgical complications for deep-seated lesions located at eloquent brain regions.…”