Evaluation of Treatment Outcomes of Early-Stage Endometrial Cancer Radiotherapy: A Single Center Experience

Demiral, Selçuk; Beyzadeoğlu, Murat; Sager, Omer; Dincoglan, Ferrat; Uysal, Bora; Gamsiz, Hakan; Akın, Mustafa; Turker, T.; Dırıcan, Bahar

doi:10.7314/apjcp.2014.15.22.9599

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…These findings are supported by those of Demiral and et al who evaluated treatment outcomes of early-stage endometrial cancer in patients who received postoperative adjuvant radiotherapy [13]. These investigators reported that grade 3 endometrial cancers and age ≥71 years were associated with reduced OS, whereas histological type was an independent predictor for local recurrence and distant metastasis [13]. Recently, Kotowicz et al studied the prognostic value of the measuring the preoperative level of CA-125 in patients with endometrial cancer and showed that CA-125 was a prognostic factor for decreased OS and DFS [14].…”

Section: Discussionsupporting

confidence: 77%

“…The data presented in the present study showed that increased serum CA-125 levels and increased histologic grade were independent predictors for disease-free survival (DFS). These findings are supported by those of Demiral and et al who evaluated treatment outcomes of early-stage endometrial cancer in patients who received postoperative adjuvant radiotherapy [13]. These investigators reported that grade 3 endometrial cancers and age ≥71 years were associated with reduced OS, whereas histological type was an independent predictor for local recurrence and distant metastasis [13].…”

Section: Discussionsupporting

confidence: 61%

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The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study

et al. 2019

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Background This retrospective clinical study aimed to investigate the effect of prognostic factors and adjuvant radiotherapy in patients with high-grade early-stage endometrial cancer on overall survival (OS) and disease-free survival (DFS). Material/Methods The medical records of patients diagnosed with high-grade, early stage (I or II) endometrial adenocarcinoma who had received adjuvant radiotherapy after surgery were reviewed. Results Seventy-nine patients included 39 patients (49.4%) with stage II endometrial cancer, 25 patients (31.6%) with histologic grade 3 tumors, and 47 patients (59.5%) with endometrial cancer showing lymphovascular space invasion (LVSI). There were 45 patients (57.0%) who received external pelvic radiotherapy with an average dose of 46.0 Gy (range, 11.2–50.4 Gy), and 34 patients (43.0%) received vaginal brachytherapy (VBT) with an average dose of 21.5 Gy (range, 10–36 Gy). Multivariate analysis showed that tumor stage (HR, 4.066; 95% CI, 1.227–13.467; p=0.022) and histologic grade (HR, 16.652; 95% CI, 4.430–62.589; p<0.001) were independent predictors for OS. Increased serum CA-125 levels (HR, 1.136; 95% CI, 0.995–1.653; p=0.047) and histologic grade (HR, 3.236; 95% CI, 1.107–15.156; p=0.015) were independent predictors for DFS. Adjuvant radiotherapy was not found to be significantly associated with improved OS (HR, 1.259; 95% CI, 0.518–3.058; p=0.612) or DFS (HR, 1.056; 95% CI, 0.994–1.123; p=0.078). Conclusions This retrospective study showed that in high-grade early-stage endometrial cancer treated with postoperative adjuvant radiotherapy, independent predictors for OS were tumor stage and grade. Adjuvant radiotherapy was not associated with improved OS or DFS.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 61%

The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study

et al. 2019

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“…The present study showed that the recurrence rate of stage I endometrial cancer was 8.2%. The RR was lower than those in other studies (11.2-19.0%) (Creutzberg et al 2000, Demiral et al 2014, Gadducci et al 2014, Keys et al 2004, which also included patients with stage II endometrial cancer, but excluded patients without MI. However, the RR in the present study was worse than other previous studies (4.8-7.0%) (Huijgens et al 2013, Jeppesen et al 2016, Rahatli et al 2014, Therasakvichya et al 2016, Zaki et al 2012 because of the large number of participants (Jeppesen et al 2016) that included only patients without MI (Zaki et al 2012).…”

Section: Discussioncontrasting

confidence: 69%

Disease Free Survival of Stage I Endometrial Cancer after Surgery with or without Adjuvant Treatment

Moradokkasem¹,

Saeaib²,

Liabsuetrakul³

2019

FMI

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This study aimed to define the disease free survival (DFS) and factors associated with recurrence in stage I endometrial cancer after surgery with and without adjuvant treatment. The demographic data, pathological results, adjuvant treatment (AT) and the outcome of patients with endometrial cancer stage I after surgery in Songklanagarind Hospital between January 2002 and July 2014 were collected. The DFS was analyzed by survival analysis and represented by Kaplan–Meier curves. The difference of DFS between AT and non-adjuvant treatment (NAT) groups was tested by the log-rank test. Distributions of risk factors by AT and recurrent status were analyzed using chi-square or Fisher exact tests for discrete factors, and unpaired t or Wilcoxon rank-sum tests for continuous factors. The 5-year DFS was; 91.6%, from a total of 268 patients. DFS in the NAT group was significantly better than that in the AT group (95.2 versus 86.5%, p-value = 0.01). Factors associated with recurrence in the NAT group were age, tumor grading, tumor size, and presence of lymphovascular involvement. Among the AT group, age and ratio of myometrial invasion were associated with recurrence. DFS in NAT was better than in AT and the potential factors associated with recurrence, after surgery with or without AT, were not the same.

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“…Regarding the sites of locoregional recuuence, our study found that the vaginal vault was the most common (50%), followed by the pelvic region (22%). This is matching with the results of the study by Demiral et al in which 46.7% recurred in the vaginal stump and 33.3% in the pelvis [18].…”

Section: Discussionsupporting

confidence: 92%

A Retrospective Study of the Treatment Results & Patterns of Failure of Type II Endometrial Cancer Patients Treated at Radiotherapy Department, NCI, Cairo University during the Period from January 2000 till December 2012

Serag¹,

Mahmoud²,

Seleem³

et al. 2016

JCT

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Aim of the study: To identify all clinico-pathological data, different treatment modalities and the different prognostic factors which affected the locoregional control (LC), disease-free survival (DFS), and overall survival (OS) of Type II endometrial cancer patients. Patients and methods: Data of Type II endometrial carcinoma patients who presented to the Radiation Oncology department, National Cancer Institute, Cairo University during the period from (2000-2012) were retrospectively reviewed. Results: Multivariate analysis identified stage as an independent prognostic factor for OS & DFS, and age was an independent prognostic factor for DFS and LC. Low pretreatment hemoglobin levels significantly affected OS. Conclusion: Large and multicentric clinical trials are required to further study this group of patients and define optimum treatment modalities.

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Evaluation of Treatment Outcomes of Early-Stage Endometrial Cancer Radiotherapy: A Single Center Experience

Cited by 7 publications

References 17 publications

The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study

The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study

Disease Free Survival of Stage I Endometrial Cancer after Surgery with or without Adjuvant Treatment

A Retrospective Study of the Treatment Results & Patterns of Failure of Type II Endometrial Cancer Patients Treated at Radiotherapy Department, NCI, Cairo University during the Period from January 2000 till December 2012

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Evaluation of Treatment Outcomes of Early-Stage Endometrial Cancer Radiotherapy: A Single Center Experience

Cited by 7 publications

References 17 publications

The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study

The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study

Disease Free Survival of Stage I Endometrial Cancer after Surgery with or without Adjuvant Treatment

A Retrospective Study of the Treatment Results &amp; Patterns of Failure of Type II Endometrial Cancer Patients Treated at Radiotherapy Department, NCI, Cairo University during the Period from January 2000 till December 2012

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A Retrospective Study of the Treatment Results & Patterns of Failure of Type II Endometrial Cancer Patients Treated at Radiotherapy Department, NCI, Cairo University during the Period from January 2000 till December 2012