Evaluation of solid-phase microextraction in combination with gas chromatography (SPME-GC) as a tool for quantitative bioanalysis

New trend in sample preparation: on-line microextraction in packed syringe for liquid and gas chromatography applications

“…The extraction is based on partitioning of the analyte between the organic phase on the fused silica fibre and the analyte. Many factors, such as pH, temperature, salt concentration and stirring, affect the equilibrium constant and the equilibration time [7][8][9][10][11][12]. The major disadvantages of SPME in quantitative analysis are low recovery (low sensitivity), the frequent inability of the fibre to withstand a complete run (standards + blanks + QC samples + patient samples) and the impossibility of treating samples in an organic solvent.…”

New trends in sample preparation: on-line microextraction in packed syringe (MEPS) for LC and GC applicationsPart III: Determination and validation of local anaesthetics in human plasma samples using a cation-exchange sorbent, and MEPS–LC–MS–MS

“…Further, SPE cartridges are relatively expensive and the systems are difficult to automate. Also SPME has been used for extraction of local anaesthetics in plasma samples [25][26][27]. Large sample volumes (≥1000 l), long sample preparation time (> 40 min), low recovery and limited life time of the fiber were some of the drawbacks with this technique.…”

Headspace-solid-phase microextraction using a dodecylsulfate-doped polypyrrole film coupled to ion mobility spectrometry for analysis methyl tert-butyl ether in water and gasoline

“…Solid-phase microextraction (SPME) has been successfully used to rapidly concentrate volatile organic compounds [8][9][10][11][12][13][14] and a wide variety of other organic compounds occurring in aqueous and other matrices [15][16][17][18][19][20][21][22][23]. Several papers reporting the determination of MTBE and other ethers in water [24][25][26][27] and gasoline [28][29][30][31] were also published.…”