New trends in sample preparation: on-line microextraction in packed syringe (MEPS) for LC and GC applicationsPart III: Determination and validation of local anaesthetics in human plasma samples using a cation-exchange sorbent, and MEPS–LC–MS–MS

Application of Gas Chromatography on the Evaluation of Grape and Wine Aroma in Atlantic Viticulture (NW Iberian Peninsula)

“…Recently, a novel methodology has been developed which corresponds to a miniaturization of the conventional SPE (Abdel-Rehim, 2010; Altun et al, 2004). It was named microextraction in packed syringe (MEPS) and the major achievement is the considerably reduction of sample, as well as the extraction and washing solvent volumes.…”

Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats

“…Determining drug concentration in biological fluids provides the fundamental information needed for the development of new drug forms (Altun et al, 2004), such as liposome preparations of local anesthetics. Moreover, pharmacokinetic determinations are fundamental in clinical practice (Adams et al, 1989).…”

Determination of Three Organochlorine Pesticides in Aqueous Samples by Solid-Phase Extraction Based on Natural Nano Diatomite in Packed Syringe Coupled to Gas Chromatography-Mass Spectrometry

“…Microextraction in a packed syringe (MEPS) is a rather new technique used for the extraction and preconcentration of trace amounts of analytes into a solid support sorbent packed inside two frits in a syringe or microsyringe. [12][13][14] In this technique, sample preparation takes place on a packed bed of the sorbent. The sorbent is inserted in the barrel of a 1-mL insulin syringe as a plug with two polyethylene filters on both sides.…”

“…Many materials, such as silica-based (C2, C8, C18) sorbents, [13][14][15] strong cation exchanger, 14 carboxyl purified multi-walled carbon nanotubes, 17 and polystyrene, 18,19 are used as the sorbent in MEPS. Begheri et al have applied a polyaniline nanowire network, 20 and a polydiphenylamine nanocomposite, 21 as the sorbent in a packed syringe for the preconcentration and extraction of OPPs.…”