Evaluation of serum lipids in preeclampsia: a comparative study

Thathagari, Varija; Kumar, Chandra M.

doi:10.18203/2320-1770.ijrcog20180998

Cited by 8 publications

(10 citation statements)

References 11 publications

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“…About 31.4% of women with PIH were found above the baseline value. This finding is in agreement with the study done by a few researchers 31–33 . This may associate with insulin resistance in HTN disorder in pregnancy that suppresses lipoprotein lipase activity and will increase free fatty acid mobilization from visceral adipocytes 34 .…”

Section: Discussionsupporting

confidence: 93%

“…This finding is in agreement with the study done by a few researchers. [31][32][33] This may associate with insulin resistance in HTN disorder in pregnancy that suppresses lipoprotein lipase activity and will increase free fatty acid mobilization from visceral adipocytes. 34 This could highlight hypercholesterolemia in HTN disorders during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of serum lipid profiles, uric acid, and high sensitivity C‐reactive protein levels between pregnancy‐induced hypertension and normotensive pregnant women attending Ambo University Referral Hospital, Ambo, Ethiopia, 2020: A case‐control study

Areda

Gizaw

Berdida

et al. 2022

Health Science Reports

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Background and Aims: Pregnancy-induced hypertension is one of the top three ranked diseases during pregnancy that cause maternal, fetal, and neonatal morbidity and mortality worldwide. To provide adequate information to clinicians and researchers who are striving for potential interventions, biochemical profiling of such patients is required.Methods: A hospital-based case-control study design was conducted from August 2020 to May 2021 to evaluate serum lipid profile, uric acid, and high sensitivity Creactive protein (hs-CRP) among women with pregnancy-induced hypertension compared to normotensive pregnant women. Data were entered and analyzed using SPSS version 25. Independent t-test and χ 2 were used to compare the relationship of variables between the two groups. A p-value less than 0.05 was used to test statistical significance. Results:The result of this study showed that while the levels (mean ± SD) of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), TC/high-density lipoprotein-cholesterol (HDL-C), TG/HDL-C, LDL-C/HDL-C were significantly elevated, HDL-C was decreased among women with pregnancy-induced hypertension than normotensive pregnant women (p < 0.0001). The levels (mean ± SD) of uric acid and hs-CRP were significantly higher among women with pregnancyinduced hypertension compared to normotensive pregnant women (p < 0.0001). Conclusion:This study indicated that pregnancy-induced hypertension women have lipid abnormalities, increased systemic inflammatory markers, and hyperuricemia compared to normotensive pregnant women. Thus, women with PIH showing high dyslipidemia, hyperuricemia, and inflammation are likely to develop hypertension.Therefore, evaluation of these potential biomarkers during early antenatal care services may help seek interventions in PIH.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Evaluation of serum lipid profiles, uric acid, and high sensitivity C‐reactive protein levels between pregnancy‐induced hypertension and normotensive pregnant women attending Ambo University Referral Hospital, Ambo, Ethiopia, 2020: A case‐control study

Areda

Gizaw

Berdida

et al. 2022

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…Serum LDL was also found to be significantly elevated (p value 0.005) in women who developed GH or PE in later pregnancy (p value 0.005) in our study (Table 2). This observation of our study is in corroboration with other studies [19,31,32] . Sensitivity of LDL to detect hypertensive disease was estimated to be 60% and specificity 56.66% in our study.…”

Section: Discussionsupporting

confidence: 94%

Second Trimester Uterine Artery Doppler Velocimetry and Serum Lipids for Prediction of Pre-Eclampsia

Saini

Maitra

Gupta

2019

ijirms

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Background: Reliable markers for prediction and prevention of pre-eclampsia to reduce its associated maternal and perinatal morbidity are lacking. Aim and objectives: To evaluate uterine artery doppler velocimetry and serum lipids in second trimester of pregnancy for prediction of gestational hypertension and pre-eclampsia. Methods: One hundred healthy and normotensive women were enrolled in 2nd trimester of pregnancy. Presence of notching in uterine artery doppler on USG and serum lipid levels were recorded. All women were followed till term/delivery to see development of pre-eclampsia / gestational hypertension later. Results: Absence of diastolic notch in 2nd trimester USG, serum triglycerides levels of <150 mg/dL and serum LDL levels of <100 mg/dL in 2nd trimester of pregnancy were found to have a good negative predictive value of 96.6%, 96.3%, 92.7% for later development of GH/PE. Conclusion: Absent diastolic notch, serum triglycerides <150mg/dL and LDL <100 mg/dL in 2nd trimester of pregnancy can be used to stratify women with low risk pregnancy.

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“…There are many facts that show lipid profile abnormalities might be associated with the risk of preeclampsia. Lipid profiles such as: TG, LDL-c, total cholesterol (TC) and very low density lipoprotein (VLDL) levels are higher in pre-eclamptic women as compared with normal pregnancies, but high-density lipoprotein (HDL) level is lower in pre-eclamptic women as compared with normal pregnancies [7][8][9]. Lipid profile abnormalities increases as the gestational age of the mother increases.…”

Section: Introductionmentioning

confidence: 99%

“…Different studies have tried to elucidate the association between the maternal serum lipid profiles and pre-eclampsia, but many of them have reported conflicting results. Some studies have shown higher levels of lipid profiles in pre-eclamptic women as compared to normotensive pregnant women [ 9 , 11 – 13 ]. However, a few studies have found non-significant difference in the serum levels of maternal lipid profiles between pre-eclamptic and normotensive pregnant women [ 14 , 15 ] and few other reports indicated lower serum lipid profiles in pre-eclamptic women as compared to normotensive controls.…”

Section: Introductionmentioning

confidence: 99%

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

2020

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Introduction Some studies have reported the association between maternal serum lipid profile abnormalities and pre-eclampsia. However, many studies have reported controversial results. Hence, this systematic review and meta-analysis was planned to generate summarized evidence on the association between maternal serum lipid profiles and pre-eclampsia in African women. Methods Four electronic databases such as; PubMed, Hinari, Google Scholar, and African Journals Online were searched for studies published in English. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument and Newcastle-Ottawa Scale were used for data extraction and quality assessment of the included studies. The meta- regression analysis was performed by Stata 14 software. The standardized mean difference (SMD) values of lipid profiles were computed to assess their association with pre-eclampsia at 95% CI. Results In this review a total of 15 observational studies were included. The mean values of triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL-c) and very low density lipoprotein- cholesterol (VLDL-c) were significantly higher in pre-eclamptic women as compared with normotensive pregnant women (TG = 229.61±88.27 and 147.00 ± 40.47, TC = 221.46 ± 45.90 and 189.67 ± 39.18, LDL = 133.92 ± 38.77 and 112.41 ± 36.08, VLDL = 41.44 ± 19.68 and 26.64 ± 7.87), respectively. The serum high density lipoprotein cholesterol (HDL-c) level was lower, but it is not statistically significant (HDL-c = 51.02 ± 16.01 and 61.80 ± 25.63) in pre-eclamptic women as compared with controls. The pooled standardized mean difference (SMD) of TG, TC, LDL-C and VLDL-C were significantly increased in pre-eclamptic women as compared with normotensive pregnant women with the SMD of (TG = 1.65 (1.10, 2.21), TC = 0.84 (0.40, 1.29), LDL-C = 0.95 (0.46, 1.45) and VLDL-C = 1.27 (0.72, 1.81)) at 95% CI, respectively, but the pooled SMD of HDL-cholesterol was decreased in pre-eclamptic women as compared with normotensive pregnant women (SMD = -0.91 (95% CI: -1.43, -0.39). Conclusions In this review, the maternal serum levels of TG, TC, LDL-c and VLDL-c were significantly associated with the risk of preeclampsia. However, HDL- cholesterol was not significantly associated but it was lower in pre-eclamptic women. Further, large scale prospective studies should verify these outcomes and it is recommended that lipid profiles should be included as a routine diagnostic test for pre-eclamptic women.

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Evaluation of serum lipids in preeclampsia: a comparative study

Cited by 8 publications

References 11 publications

Evaluation of serum lipid profiles, uric acid, and high sensitivity C‐reactive protein levels between pregnancy‐induced hypertension and normotensive pregnant women attending Ambo University Referral Hospital, Ambo, Ethiopia, 2020: A case‐control study

Evaluation of serum lipid profiles, uric acid, and high sensitivity C‐reactive protein levels between pregnancy‐induced hypertension and normotensive pregnant women attending Ambo University Referral Hospital, Ambo, Ethiopia, 2020: A case‐control study

Second Trimester Uterine Artery Doppler Velocimetry and Serum Lipids for Prediction of Pre-Eclampsia

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

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