Evaluation of serum adenosine deaminase levels with components of metabolic syndrome

Sajjan, Netravathi Basappa; Makandar, Asmabi

doi:10.5958/2394-6377.2016.00055.1

Cited by 5 publications

(5 citation statements)

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“…Reports have it that increased activity of ADA reduces adenosine level in the nervous cardiac tissue, which causes limitation in the synthesis of adipokines; a regulatory protein involve in the immune systems (Adefegha, Oyeleye, Akintemi, Okeke, & Oboh, 2020; Sajjan & Makandar, 2016). The increased ADA activity in the cardiac tissue of CsA‐stressed rats, connote possible depletion adenosine and impair purinergic metabolism.…”

Section: Discussionmentioning

confidence: 99%

Extracts from Almond ( Terminalia catappa ) leaf and stem bark mitigate the activities of crucial enzymes and oxidative stress associated with hypertension in cyclosporine A‐stressed rats

et al. 2020

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We investigated the effect of extracts from the leaf (ALE) and stem bark (ABE) of Almond tree on activities of some crucial enzymes [angiotensin-1 converting enzyme (ACE), arginase, acetylcholinesterase (AChE), phosphodiesterase-5 (PDE-5), adenosine deaminase (ADA), superoxide dismutase (SOD), catalase], and thiobarbituric acid reactive species (TBARS) associated with hypertension in normal adult male Wistar albino rats and Cyclosporine A (CsA)-stressed rats. The result revealed that CsAstressed rats treated with captopril and extracts (ALE and ABE) had lowered ACE, arginase, AChE, PDE-5, ADA activities, and TBARS level, coupled with improved SOD and catalase activities compared with untreated CsA-stressed rats, which had reversed these biochemicals compared to normal rats. This suggests that the extracts could be explored to suppress hypertension and other cardiac injury known with CsA treatment; the potentials that could be linked with the constituent polyphenols. However, further studies including blood pressure should be determined to ascertain this claim. Practical applications Drug-induced cardiotoxicity, hypertension, and organ damage are among the most common side effects of pharmaceutics. Therefore, it becomes imperative to find natural, effective, and alternative therapy with little or no side effect to combat drug toxicity. The use of Almond (leaf and stem bark) in folklore for the treatment/management of hypertension and other heart-related diseases without full scientific basis is on the increase. Hence, this study provides some biochemical evidences on the effect of Almond leaf and stem back extracts on crucial enzymes and oxidative stress markers involve in the incidence of hypertension in the course of Cyclosporine A administration. The findings of this study indicated that the studied plant materials could be promoted as nutraceutical agents to neutralize drug-induced cardiac injury and hypertension.

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Section: Discussionmentioning

confidence: 99%

Extracts from Almond ( Terminalia catappa ) leaf and stem bark mitigate the activities of crucial enzymes and oxidative stress associated with hypertension in cyclosporine A‐stressed rats

et al. 2020

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“…Overactivity of serum ADA has been described in patients with increased cardiometabolic risk and atherosclerosis. The correlation analysis of cardiometabolic syndrome risk factors against ADA also showed a strong association [ 112 ]. This is in line with recent results of Simard et al, where advancing age and the presence of obstructive coronary artery disease were associated with lower plasma adenosine levels [ 113 ].…”

Section: Cardiovascular Pathologies Associated With Increased Ada mentioning

confidence: 99%

“…Rao et al demonstrated higher serum ADA activity in gestational hypertensive women than in normotensive pregnant women [ 151 ]. In other study, Sajjan et al showed a significant positive correlation between enhanced serum ADA levels and increase in systolic (SBP) and diastolic blood pressure (DBP) in subjects with metabolic syndrome [ 112 ]. Also our results revealed a strong positive correlation of tissue eADA activity estimated in calcified aortic valves with SBP and DBP in patients with calcified aortic valve disease [ 24 ].…”

Section: Cardiovascular Pathologies Associated With Increased Ada mentioning

confidence: 99%

Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases

et al. 2020

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Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts adenosine to inosine or 2′deoxyadenosine to 2′deoxyinosine. ADA is active both inside the cell and on the cell surface where it was found to interact with membrane proteins, such as CD26 and adenosine receptors, forming ecto-ADA (eADA). In addition to adenosine uptake, the activity of eADA is an essential mechanism that terminates adenosine signaling. This is particularly important in cardiovascular system, where adenosine protects against endothelial dysfunction, vascular inflammation, or thrombosis. Besides enzymatic function, ADA protein mediates cell-to-cell interactions involved in lymphocyte co-stimulation or endothelial activation. Furthermore, alteration in ADA activity was demonstrated in many cardiovascular pathologies such as atherosclerosis, myocardial ischemia-reperfusion injury, hypertension, thrombosis, or diabetes. Modulation of ADA activity could be an important therapeutic target. This work provides a systematic review of ADA activity and anchoring inhibitors as well as summarizes the perspectives of their therapeutic use in cardiovascular pathologies associated with increased activity of ADA.

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“…Enzymes that are responsible for adenosine activity includes 5nucleotidase, adenosine deaminase and adenosine kinase. In adipose tissue, adenosine degraded by ADA, so more synthesized of adenosine lead to increase ADA, whereas the formation of extracellular adenosine depends on an enzyme cascade for metabolism of ATP, ADP, and AMP, that sound to be the greater mechanism that leads to elevated extracellular adenosine [40].…”

Section: Discussionmentioning

confidence: 99%

Estimation of Nitric Oxide, Malondialdehyde, and Adenosine Deaminase in Serum of Hypertensive Patients and Normotensive Individuals in Erbil City

Ibrahim¹,

Abdulkareem²,

Hasan³

2019

Tikrit J. Pure Sci.

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This study was aimed to estimate nitric oxide (NO), malondialdehyde (MDA), and adenosine deaminase (ADA) in the serum of hypertensive patients. Fifty patients (25 males and 25 females) age 40-70 diagnosed with hypertension involved in the study. Fifty healthy individuals, who had no hypertension in the last year, were identified as the control group. NO, MDA and ADA have performed accordingly. MDA was higher with aging and gender in hypertensive patients. Serum level of MDA was higher in females compared with male due to oxidative stress more in female than a male with aging. ADA was higher among hypertensive with aging, though no significant differences among gender. Serum level of NO was lower with aging with no significant differences among gender.

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Evaluation of serum adenosine deaminase levels with components of metabolic syndrome

Cited by 5 publications

References 0 publications

Extracts from Almond ( Terminalia catappa ) leaf and stem bark mitigate the activities of crucial enzymes and oxidative stress associated with hypertension in cyclosporine A‐stressed rats

Extracts from Almond ( Terminalia catappa ) leaf and stem bark mitigate the activities of crucial enzymes and oxidative stress associated with hypertension in cyclosporine A‐stressed rats

Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases

Estimation of Nitric Oxide, Malondialdehyde, and Adenosine Deaminase in Serum of Hypertensive Patients and Normotensive Individuals in Erbil City

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