Evaluation of Safety of<i>Arrabidaea chica</i>Verlot (Bignoniaceae), a Plant with Healing Properties

Gemelli, Tiago Farret; Prado, Lismare da Silva; Santos, Franciele Souza; Souza, Ana Paula de; Guecheva, Temenouga Nikolova; Henriques, João Antônio Pêgas; Ferraz, Alexandre de Barros Falcão; Corrêa, Dione Silva; Dihl, Rafael Rodrigues; Picada, Jaqueline Nascimento

doi:10.1080/15287394.2015.1072070

Cited by 17 publications

(10 citation statements)

References 26 publications

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“…A previous study [52] also demonstrated the efficiency of A. chica in the treatment of anemia, inflammation, intestinal colic, hepatitis, and skin infections. The research group evaluated the crude aqueous extract and the fractions of Arrabidaea in Salmonella tests to investigate the mutagenic potential of the chemical compounds in A. chica.…”

Section: Main Chemical Composition Of a Chicamentioning

confidence: 82%

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

et al. 2022

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The genus Arrabidaea, consisting of ~170 species, belongs to the family Bignoniaceae, distributed around the Neotropics and temperate zone. The center of diversity of the family is in Brazil, where 56 genera and about 340 species exist. Most species of the genus Arrabidaea are traditionally utilized as diuretics and antiseptics, as well as for treating intestinal colic, diarrhea, kidney stones, rheumatoid arthritis, wounds, and enterocolitis. The genus is chemically diverse with different substance classes; most of them are triterpenes, phenolic acids, and flavonoids, and they exhibit valuable pharmacological properties, such as antitumor, antioxidant, leishmanicidal, trypanocidal, anti-inflammatory, and healing properties. This review presents information on the chemical constituents isolated from seven Arrabidaea species, and the pharmacological activities of the extracts, fractions and pure substances isolated since 1994, obtained from electronic databases. The various constituents present in the different species of this genus demonstrate a wide pharmacological potential for the development of new therapeutic agents, however its potential has been underestimated.

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Section: Main Chemical Composition Of a Chicamentioning

confidence: 82%

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

et al. 2022

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“…According to the literature, pharmacological studies have demonstrated cytotoxic and leishmanicidal potential (Cortez de S a et al, 2016), anti-T. cruzi (Barbosa et al, 2008), anti-inflammatory, antiangiogenic and antiproliferative activities (Michel et al, 2015), antimicrobial activity (Mafioleti et al, 2013) and significant antioxidant activity (Siraichi et al, 2013). Previous phytochemical studies of this plant have shown the presence of tannins, flavonoids (7,4 0 -dihydroxy-5methoxyflavone, luteolin, carajuruflavone, apigenin, escutelarina and isoescutelarina), phytosterols, anthocyanidins and pigments used in cosmetics like carajurone and carajurin (Zorn et al, 2001; Barbosa et al, 2008;Gemelli et al, 2015).…”

Section: Introductionmentioning

confidence: 93%

In vitro toxicological assessment of Arrabidaea brachypoda (DC.) Bureau: Mutagenicity and estrogenicity studies

Resende

Nogueira

Espanha

et al. 2017

Regulatory Toxicology and Pharmacology

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Arrabidaea brachypoda (DC.) Bureau is a shrub native Cerrado, known as "cipó-una", "tintureiro" or "cervejinha do campo" and popularly used in Southeastern and Northeastern Brazil to treatment of kidney stones and painful joints (arthritis). Nevertheless, scientific information regarding this species is scarce, and there are no reports related to its possible estrogenic and mutagenic effects. Thus, the principal objective of this study was to assess the mutagenic and estrogenic activities of the hydroalcoholic extracts of the leaves, stalks, roots, their respective fractions and isolated compounds of A. brachypoda. The mutagenic activity was evaluated by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, in the absence (-S9) and presence (+S9) of metabolic activation system. In the RYA was used Saccharomyces cerevisiae engineered strain BY4741 (MATaura3Δ0 leu2Δ0 his3Δ1 met15Δ0) which reproduce the natural pathway of genetic control by estrogens in vertebrate cells; it has the advantage of its simplicity and a high throughput. All extracts and aqueous fraction of leaves A. brachypoda were mutagenic. The crude extract is more active than the fraction, suggesting a synergic effect. Only hydroalcoholic extracts of leaves and roots of A. brachypoda showed significant estrogenic activity, with ERα-dependent transcriptional activation activity. The obtained results in this study showed the presence of compounds capable of interacting with the estrogen receptor and to induce damage in the genetic material. Thus, we demonstrated the risk which the population is subjected due to indiscriminate use of extracts without detailed study.

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“…The isolated compound [1] was also non-cytotoxic, with IC 50 > 400 µg/mL for CHO-k1 and 387.00 ± 4.06 µg/mL for RAW 264.7. These results complement previous works indicating than HEFc does not cause any signs of acute toxicity in mice when administered in vivo at doses up to 3 g/kg p.o., and the absence of mutagenic or genotoxic risks (Mafioleti et al 2013;Gemelli et al 2015).…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Anti-inflammatory activity of 4′,6,7-trihydroxy-5-methoxyflavone from Fridericia chica (Bonpl.) L.G.Lohmann

Lima

Oliveira

Silva

et al. 2018

Natural Product Research

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Fridericia chica, Bignoniaceae, is a tropical tree-creeper used as a traditional remedy for a number of diseases, highlighting inflammation. Our objective was to corroborate the popular anti-inflammatory use of the hydroethanolic extract from the leaves (HEFc) and of its isolated 4',6,7-trihydroxy-5-methoxyflavone (5-Omethylscutellarein) [1], described here for the first time. Quantitative analysis indicated 8.77 ± 0.23 mg/g of this compound in the extract. Neither HEFc nor [1] was cytotoxic in vitro. In LPS-induced peritonitis in mice, oral pre-treatment with HEFc or[1] led to decreased leukocyte migration to the peritoneal cavity and a reduction in the concentrations of pro-inflammatory cytokines (TNF and IL-1. Also, the antiinflammatory cytokine IL-10 was enhanced following treatment with [1]. Overall, these results validate the traditional use of Fridericia chica as anti-inflammatory, and indicate that the compound 5-O-methylscutellarein may participate in this effect.

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Evaluation of Safety ofArrabidaea chicaVerlot (Bignoniaceae), a Plant with Healing Properties

Cited by 17 publications

References 26 publications

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

In vitro toxicological assessment of Arrabidaea brachypoda (DC.) Bureau: Mutagenicity and estrogenicity studies

Anti-inflammatory activity of 4′,6,7-trihydroxy-5-methoxyflavone from Fridericia chica (Bonpl.) L.G.Lohmann

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