Anti-inflammatory activity of 4′,6,7-trihydroxy-5-methoxyflavone from <i>Fridericia chica</i> (Bonpl.) L.G.Lohmann

Lima, Joaquim C. S.; Oliveira, Ruberlei Godinho de; Silva, Virginia C.; Sousa, Paulo Teixeira de; Violante, Ivana Maria Póvoa; Macho, Antonio; Martins, Domingos Tabajara de Oliveira

doi:10.1080/14786419.2018.1495636

Cited by 23 publications

(24 citation statements)

References 12 publications

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“…A. chica extract also demonstrated this effect by inhibiting nuclear transcription factor kappaβ, which consequently prevents the formation of inflammatory mediators such as iNOS, COX-2, 5-LOX, and phospholipase A 2 [18]. Studies by Lima et al [32] also observed that in lipopolysaccharide-induced peritonitis in mice, oral pretreatment with hydroethanolic extract of the leaves or with the isolated compound 4′,6,7-trihydroxy-5-methoxyflavone (5- o -methyl scutellarein) led to decreased leukocyte migration to the peritoneal cavity, as well as a reduction in proinflammatory cytokine concentrations (TNFα and IL-1β).…”

Section: Discussionmentioning

confidence: 99%

Effects of Extract of Arrabidaea chica Verlot on an Experimental Model of Osteoarthritis

Vasconcelos

Lopes

Sousa

et al. 2019

IJMS

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The aim of this study was to analyze the analgesic potential of Arrabidaea chica extract (EHA) as an alternative to osteoarthritis (OA) treatment. Thus, the extract was initially evaluated by the cyclooxygenase inhibition test. The analgesic effect of the extract, in vivo, was also verified in a model of OA induced by sodium monoiodoacetate (2 mg). EHA was administered to rats at doses of 50, 150, and 450 mg/kg between 3 and 25 days after OA induction. The animals were clinically evaluated every 7 days, euthanized at 29 days, and the liver, spleen, kidney and knee collected for histopathological analysis. The chemical composition of EHA was identified by HPLC-MS and the identified compounds submitted to molecular docking study. The results showed that the extract promoted cyclooxygenase inhibition and produced significant improvements in disability, motor activity, hyperalgesia, and OA-induced allodynia parameters, in addition to improvements in the radiological condition of the knees (but not observed in the histopathological study). Chemically the extract is rich in flavonoids. Among them, we evidence that amentoflavone showed very favorable interactions with the enzyme COX-2 in the in silico analysis. Thus, it is concluded that A. chica has important analgesic properties for the treatment of OA.

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Section: Discussionmentioning

confidence: 99%

Effects of Extract of Arrabidaea chica Verlot on an Experimental Model of Osteoarthritis

Vasconcelos

Lopes

Sousa

et al. 2019

IJMS

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“…Fridericia chica (synonym Arrabidaea chica) leaves are usually employed as a red dye, in fact, it has traditionally been used by Sinu artisans of the Colombian Caribbean to make the vueltiao hat [2]. The red color obtained from F. chica comes from anthocyanidins, a class of phenolic compounds with known antioxidant properties [3], and extracts from the plant have shown pharmacological activities linked to beneficial health effects, including anti-inflammatory [4], antiproliferative [5], wound healing [6], antispasmodic [7], photoprotective [8], and leishmanicidal [9] activities. Many of these properties are attributed to different flavonoid compounds reported in F. chica, such as isoscutellarein, 6-hydroxyluteolin, hispidulin, scutellarein, luteolin, apigenin, and hispidulin [10], this last a potential compound for neuroinflammation inhibition [11].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of the Hydroethanolic Extract of Fridericia chica on Undifferentiated Human Neuroblastoma Cells Exposed to α-Zearalenol (α-ZEL) and β-Zearalenol (β-ZEL)

Álvarez-Ortega

Caballero-Gallardo

Taboada-Alquerque

et al. 2021

Toxins

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Fridericia chica (Bignoniaceae) is a traditional medicinal plant. The aim of this research was to determine the protective effects of the hydroethanolic extract from the F. chica leaves (HEFc) against the cytotoxicity of zearalenone (α-ZEL) and β-ZEL on SH-SY5Y cells. Free radical scavenging activity of HEFc was evaluated using the DPPH method. The cytotoxicity of both zearalenone metabolites and HEFc was examined using MTT test, as was the cytoprotective effects of the HEFc on cells treated with these mycotoxins. The chemical composition of HEFc was determined using UPLC-QTOF-MS/MS. HEFc elicited good DPPH radical scavenging activity following a concentration-dependent relationship. Cells exposed to α-ZEL exhibited a viability ˂50% after 48 h of treatment (25 and 50 µM), while those exposed to β-ZEL showed viability ˂50% (100 µM) and ˂25% (25-100 µM) after 24 and 48 h of exposure, respectively. HEFc showed a significant increase in cell viability after exposure to α-ZEL (25 and 50 µM) and β-ZEL (6–100 µM) (p < 0.05). UPLC-QTOF-MS/MS analyses allowed the identification of 10 phytochemical components in the HEFc. In short, the hydroethanolic extract of F. chica grown in Colombian Caribbean can protect against the effects of mycotoxins and it is a valuable source of compounds with antioxidant properties.

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“…For example, apigenin (Perrott et al, 2017) and allicin (Borlinghaus et al, 2014) have been shown to exhibit some antitumor activity. Similarly, flavonoids, compounds that are present mainly in vegetables and citrus fruits, also exert anti-inflammatory, antiangiogenetic, and proapoptotic effects (Kohno et al, 2001; Lima et al, 2018; Ferreira de Oliveira et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells

et al. 2019

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Nobiletin is a polymethoxy flavonoid isolated from Citrus depressa and Citrus reticulata. It has been reported that nobiletin can suppress tumors. We primarily explored the antitumor effects of nobiletin and the associated potential mechanisms in ACHN and Caki-2 renal carcinoma cells. A CCK-8 assay and cloning experiments were used to assess cell viability, and a transwell assay and scratch test were used to assess metastatic ability. The cell cycle was analyzed by flow cytometry, whereas apoptosis was analyzed using flow cytometry and a terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay. Protein expression was examined by Western blot and immunofluorescence. Renal cancer cells were subcutaneously transplanted into nude mice for in vivo studies. The data showed that nobiletin administration significantly dose-and time-dependently suppressed renal cancer cell proliferation; moreover, nobiletin treatment induced cell cycle arrest in the G0/G1 phase and promoted apoptosis. Immunofluorescence analysis indicated that nobiletin decreased the nuclear localization of signal transducer and activator of transcription 3 (STAT3) and YY1-associated protein 1 (YY1AP1). Western blot showed that the levels of phosphorylated SRC, phosphorylated AKT serine/threonine kinase (AKT), and phosphorylated STAT3 were decreased, whereas that of phosphorylated YY1AP1 was increased. The results further showed that application of insulin-like growth factor 1 (IGF1) was able to reverse the nobiletin-induced changes in the levels of phosphorylated AKT, phosphorylated STAT3, and phosphorylated YY1AP1, and could also reverse the antitumor effects of nobiletin. The results of in vivo experiments showed that, compared to the control, tumor volume and weight were both reduced following nobiletin treatment. In conclusion, our study demonstrated that nobiletin can inhibit renal carcinoma cell viability and provides a novel therapeutic approach for the treatment of kidney cancer.

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Anti-inflammatory activity of 4′,6,7-trihydroxy-5-methoxyflavone from Fridericia chica (Bonpl.) L.G.Lohmann

Cited by 23 publications

References 12 publications

Effects of Extract of Arrabidaea chica Verlot on an Experimental Model of Osteoarthritis

Effects of Extract of Arrabidaea chica Verlot on an Experimental Model of Osteoarthritis

Protective Effects of the Hydroethanolic Extract of Fridericia chica on Undifferentiated Human Neuroblastoma Cells Exposed to α-Zearalenol (α-ZEL) and β-Zearalenol (β-ZEL)

Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells

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