Evaluation of Risk Factors and Seroprevalence of Hepatitis B and C in Diabetic Patients in Kutahya, Turkey

Abstract

We determined that hepatitis B virus and hepatitis C virus infections were slightly but not significantly higher in diabetic patients compared with a normal population. If it is considered that different results might be obtained in various countries or even in various regions of same country, it may be concluded that multicenter and comprehensive studies are needed to elucidate true infection rates and to identify other risk factors affecting the prevalence of these infections.

Assessment of Evidence for Positive Association and Seroprevalence of Hepatitis B and C in Diabetic Patients in a Developing Country

“…The seropositivity prevalence for anti-HCV in our study is in agreement with the rate reported in these studies. Our findings are also in agreement with those of other studies performed in different areas of Turkey, 21,23 except the study of Gulcan et al 10 They reported that although the rates of anti-HCV seropositivity in Turkish diabetic patients were higher than control group, they did not reach statistically significance. We determined the presence of T2DM as a risk factor for HCV infection in this region.…”

Increased Risk of Acute Hepatitis B among Adults with Diagnosed Diabetes Mellitus

“…In 1999-2010, NHANES, a nationally representative survey that excludes institutionalized adults, found a 60% (p < .001) higher seroprevalence of anti-HBc among adults with diabetes than adults without diabetes. 30 In Turkey, Gulcan and colleagues 31 compared 630 persons with diabetes and 314 persons without diabetes attending an internal medicine clinic and found HBV infections were increased but not significantly more common among persons with diabetes compared with persons without diabetes (5.1% versus 3.8%); however, investigators noted significant correlations between HBsAg-positive serology (indicative of chronic hepatitis B) and history of hospital admission, long duration of diabetes, and use of insulin. Halota and associates 32 identified anti-HBc seropositivity among 123 (39.0%) of 315 persons with diabetes in Poland.…”

Hepatitis C virus and type 2 diabetes

“…However, the study by Sotiropoulos et al [26] reported a rather low HCV prevalence (1.65%), especially if one considers that a field survey in the Greek general population gave a HCV seroprevalence of 1.25% [34] . Other controlled studies from Italy [28] , Nigeria [31] and Turkey [33] have failed to find an excess prevalence of HCV infection among patients with T2D. The data have therefore proven inconclusive.…”

“…measuring the prevalence of HCV markers among populations of diabetic patients [8,15,[25][26][27][28][29][30][31][32][33] . Most controlled studies have suggested a significant association, the proportion of HCV-positive persons among diabetics being two-to seven-fold compared to controls [8,15,29,32] .…”