Increased Risk of Acute Hepatitis B among Adults with Diagnosed Diabetes Mellitus

Reilly, Meredith; Schillie, Sarah; Smith, Emily Ann; Poissant, Tasha; Vonderwahl, Candace; Gerard, Kristin; Baumgartner, Jennifer; Mercedes, Lynne; Sweet, Kristin; Muleta, Daniel; Zaccaro, Daniel; Klevens, R. Monina; Murphy, Trudy V.

doi:10.1177/193229681200600417

Cited by 67 publications

(58 citation statements)

References 26 publications

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“…A number of studies have identified an association between HBV infection and the prevalence of DM; however, the results of those studies were inconclusive. Certain studies have supported the increased risk of DM in HBV-infected patients when compared with non-HBV-infected controls (4)(5)(6)(7)(8)(9) and certain studies have had different results (10)(11)(12)(13)(14)(15)(16)(17). To the best of our knowledge, no meta-analysis has ever focused on assessing the association between HBV infection and the risk of DM.…”

Section: Introductionmentioning

confidence: 99%

Association between hepatitis B virus infection and diabetes mellitus: A meta-analysis

Cai

Zeng

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Hepatitis B virus (HBV) infection has been shown by certain studies to be associated with diabetes mellitus (DM); however, the results of these studies were controversial. For that reason, a meta-analysis of the literature was performed in order to determine the association between HBV infection and the prevalence of DM more accurately. The PubMed, Embase, Chinese National Knowledge Infrastructure and Wan Fang databases, as well as the Chinese Science and Technology Journal Database, were searched for literature published until June 2014. The reference lists of all relevant articles were also searched. The summary odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were calculated based on a random-effects model. Heterogeneity was assessed using the I 2 statistic. Subgroup analyses were conducted based on study type and region for the purpose of assessing the factors that could potentially affect the outcome. A total of 15 eligible studies (in 14 articles) were selected for the meta-analysis, involving 12,974,690 HBV-infected patients and 231,776,232 controls. The OR for the prevalence of DM was 1.33 (95% CI, 1.09-1.62; P=0.005) between the patients with HBV infection and the controls. The subgroup analysis based on study type revealed a significantly higher prevalence of DM in the HBV-infected group than that in the control group in both case-control (OR, 1.89; 95% CI, 1.08-3.30; P=0.025) and cross-sectional (OR, 1.41; 95% CI, 1.04-1.90; P=0.027) studies. The subgroup analysis based on region revealed a significantly higher prevalence of DM in the HBV-infected group than in the control group in the Asia-Pacific region (OR, 1.67; 95% CI, 1.08-2.58; P=0.022). Compared with uninfected patients, the pooled results suggest that HBV-infected patients have a higher risk of developing DM; however, given the fact that this is a meta-analysis of observational studies, further randomized controlled trials are required in order to reach a more accurate conclusion.

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Section: Introductionmentioning

confidence: 99%

Association between hepatitis B virus infection and diabetes mellitus: A meta-analysis

Cai

Zeng

et al. 2015

Experimental and Therapeutic Medicine

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“…Demir et al reported from Turkey that the prevalence of occult HBV infection is higher in diabetics compared with healthy controls [4]. The results from a study conducted in the United States found that the odds ratio (OR) for acute hepatitis B in adults with diabetes was 1.9 (95% confidence interval [CI]: 1.4-1.6) compared with nondiabetics [5]. However, the data from studies in Ethiopia and Nigeria showed no significant difference of HBV infection risk between diabetic patients and controls [6,7].…”

Section: Introductionmentioning

confidence: 94%

“…Previously, the association between T2DM and HBV infection was studied in different populations [4][5][6][7]. Demir et al reported from Turkey that the prevalence of occult HBV infection is higher in diabetics compared with healthy controls [4].…”

Section: Introductionmentioning

confidence: 99%

Serological and molecular analysis on the relationships between type 2 diabetes mellitus and hepatitis B virus infection

Zhu

Wang

Yu³

et al. 2016

J Infect Dev Ctries

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Introduction: This study aimed to further analyze the associations between type 2 diabetes mellitus (T2DM) and hepatitis B virus (HBV) infection, and to investigate the relationships between T2DM and the mutations within the HBV major hydrophilic region (MHR). Methodology: In this cross-sectional study, 3,377 persons (338 T2DM patients and 3,039 non-diabetics) were randomly selected. HBsAg detection was performed by enzyme-linked immunosorbent assay. The HBV MHR was amplified, sequenced, and analyzed by nested PCR. Results: The seroprevalence of HBsAg was 21.30% in T2DM patients (72/338), which was significantly higher than in non-diabetics (15.53%). Compared to persons without T2DM, the proportion of T2DM patients positive for HBsAg was significantly elevated in males, people > 55 years (p = 0.039), and people with a body mass index (BMI) ≥ 24 kg/m 2 . Totally, 112 genotype B and 111 genotype C HBV sequences were isolated. No significant difference in HBV genotype distribution was observed between T2DM patients and non-diabetics. Compared to genotype C HBV-infected cases in non-diabetics, the amino acid substitution rates in the MHR were significantly higher in T2DM patients (p = 0.003). Moreover, seven HBV strains with stop codon mutations within the HBV S gene were identified: three from T2DM patients (5.45%) and four from non-diabetics (2.38%). Conclusions: In China, T2DM is significantly associated with chronic HBV infections and genotype C HBV MHR mutations. Being males, > 55 years of age, and ≥ 24 kg/m 2 of BMI are the risk factors of HBV infection in T2DM patients.

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“…Diyabetik hastalarda influenza ve pnömokok aşılamalarının artmasıyla bu durumun önüne geçmek mümkündür (5,6). Diyabetli hastalarda akut hepatit B enfeksiyonu sağlıklı populasyona göre daha sık görülmektedir (7). Bu veriye bağlı olarak kronik hepatit B enfeksiyonriski de artmaktadır.…”

Section: Introductionunclassified

Diyabetik Hastalarin Hepatit-B, Influenza ve Pnomokok Asi Farkindaliklari

2016

GMJ

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ÖZETAmaç: Bu çalışmada ana amaç olarak diyabetik hastalarda Hepatit-B, İnfluenza ve Pnömokok aşılarının yapılması gerekliliği hakkında hastaların farkındalığının saptanması belirlenmiştir. İkincil amaçlar olarak Hepatit-B, İnfluenza ve Pnömokok aşılarının yaptırmalarının gerekli olduğunun farkında olan hastaların bu bilgiyi nereden edindiklerinin saptanması ve bilgi edindikleri kaynağın (doktor, tv, komşu vb.) aşı yaptırmaları üzerine olan etkisinin belirlenmesi hedeflenmiştir. Yöntem: Diyabet-Obezite polikliniğine başvuran diyabetik hastalardan Diyabet Aşı Anketini doldurmaları istendi. Anketi doldurmayı kabul eden hastalar gerekli yerlerde Doktor yardımıyla birlikte anketi doldurdular. Tamamlanan anketlerin veri girişi yapıldı. İstatistik çalışmaları SPSS programı ile yapıldı. Bulgular: Çalışmaya 318 hasta katıldı. Ortalama yaş 54,77 idi (%61,9 kadın, %38,1 erkek). Hastaların %90,9'u Ankarada yaşamaktaydı. %37,7 oranda ilkokul mezunu, %28 lise mezunu, %28 üniversite mezunu iken %5 hastanın okuma-yazması yoktu. Hastaların %6,9'u Tip 1 diyabetik, diğerleri Tip 2 diyabetikti. Ortalama diyabet süresi 8,8 yıldı. %46,3 hasta influenza aşısı, %18,9 hasta pnömokok aşısı ve %34,5 hasta hepatit-B aşısı yaptırmaları gerektiğini biliyorlardı. Hastalar bu bilgiyi büyük oranda doktor önerisi yoluyla edinmişlerdi. (İnfluenza aşısı grubunun %72'si, pnömokok aşısı grubunun %75'i ve hepatit-B aşısı grubunun %71,6'sı.) Aşı konusunda bilgilendirme yapan doktorların büyük bir kısmını Aile hekimleri, dahiliye doktorları ve endokrinologlar oluşturmaktaydı. (Üç doktor grubunun ortak oranları İnfluenza aşısı grubunda %81,7, pnömokok aşısı grubunda %76,8 ve hepatit-B aşısı grubunda %72,6 idi.) Bilgi kaynağı olarak ikinci sırayı bütün gruplarda televizyon aldı. (İnfluenza aşısı grubunun %16,7'si, pnömokok aşısı grubunun %19,6'i ve hepatit-B aşısı grubunun %18,6'sı.) Hastaların tümünde influenza aşısı yaptıranların oranı 14,6, pnömokok aşısı yaptıranların oranı %3,8, hepatit B aşısı yaptıran oranları %15,5 olarak saptandı. Hepatit-B grubunda öğrenim durumun yükselmesiyle birlikte aşılanma oranının da arttığı gözlendi. Diğer gruplarda bu ilişki saptanmadı. Bilgi edinilen kaynağın aşılanma oranları üzerinde etkisi olmadığı gözlendi. Sonuç: Çalışmamızda diyabetik hastlarda aşılanma gerekliliği konusunda farkındalığın ve aşılanma oranlarının gelişmiş ülkelerdeki oranların altında olduğu gözlendi. Bu oranların artması için sağlık birimlerinin daha çok çalışması gereklidir. ABSTRACT Objective:The main purpose of this study is to determine the awareness of diabetic patients on the necessity of having hepatitis B, influenza and pneumococcal vaccinations. As secondary objectives, the resources of this information and the influence of the resource (doctor, tv, neigbour etc.) on having this vaccination were evaluated. Material and Method: Diabetic patients referred to the Diabetes-Obesity clinic were asked to fill the Diabetes Vaccine Questionnaire. Patients who agree to fill out the questionnaire completed the forms with the help of doctors. Comp...

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Increased Risk of Acute Hepatitis B among Adults with Diagnosed Diabetes Mellitus

Cited by 67 publications

References 26 publications

Association between hepatitis B virus infection and diabetes mellitus: A meta-analysis

Association between hepatitis B virus infection and diabetes mellitus: A meta-analysis

Serological and molecular analysis on the relationships between type 2 diabetes mellitus and hepatitis B virus infection

Diyabetik Hastalarin Hepatit-B, Influenza ve Pnomokok Asi Farkindaliklari

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