Evaluation of reversible interconversion in comprehensive two-dimensional gas chromatography using enantioselective columns in first and second dimensions

A One-Pot/Single-Analysis Approach to Substrate Scope Investigations Using Comprehensive Two-Dimensional Gas Chromatography (GC×GC)

“…Coupling of GC×GC with a flame ionization detector (FID) allows for the necessary separations but also the capacity to get reasonably accurate concentrations of every compound within the GC×GC chromatogram because most hydrocarbons have similar response factors . With the incorporation of a chiral column into the first (“chiral-GC×GC”) or second-dimension (“GC×chiral-GC”), enhanced resolution of enantiomers can be achieved, and has been reported for the analysis of chiral terpenes within plant extracts, petroleum-contaminated marine sediments, and more recently to study dynamic molecular interconversion processes . However, both chiral-GC×GC and GC×chiral-GC remain fairly underdeveloped, perhaps restricted by the relatively low maximum temperature limits of standard chiral GC columns with GC×GC used primarily to study petroleum (maximum chiral GC column temperatures are generally ∼230–250 °C which would correspond to a limit of n -alkanes < ∼C 20 ).…”

Enantiomer separation of propranolol and tryptophan using bovine serum albumin functionalized silica nanoparticles as adsorbents

“…Chirality is a widespread phenomenon in nature and organisms. 1 The separation of chiral components to pure enantiomers is of great importance to pharmaceutical, food, toxicological and clinical analysis. In general, a single pure isomer is the active component of one drug and the other isomer may be inactive, or even have dramatic, negative side effects.…”

Observation and explanation of two-dimensional interconversion of oximes with multiple heart-cutting using comprehensive multidimensional gas chromatography

“…MDGC has been applied to interconverting compounds, to study the molecular behaviour of these processes [12]. In a variation on the method, on-line interconversion in GC GC was observed where chiral phases were employed in both 1 D and 2 D [13], for a chiral oxime, to accomplish R/S separation and E/Z isomerisation. Enantioseparation is difficult to achieve with a short column, but the strategy employed a longer enantioselective column, allowing 'wraparound' i.e.…”