2019
DOI: 10.1590/s1677-5538.ibju.2019.0016
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Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum

Abstract: Cinnamomum cassia (Cinnamon) is a well-known traditional medicine with therapeutic benefits for centuries. We evaluated the effects of cinnamon essential oil (CEO) and its main component cinnamaldehyde (CA) on human corpus cavernosum (HCC) and rat CC. The essential oil of cinnamon was analyzed for the confirmation of the oil profile. HCC specimens from patients undergoing penile prosthesis surgery (age 48-69 years) were utilized for functional studies. In addition, erectile responses in anesthetized control an… Show more

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Cited by 6 publications
(3 citation statements)
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References 25 publications
(36 reference statements)
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“…With regard to diabetes-related macrovascular and microvascular complications, Ci reduced vascular resistance and stenosis, and protected from hypertension in diabetic rats and mice [28][29][30]. In vivo and in vitro, Ci induced relaxation of rat aorta [31], mice mesenteric arteries [32], porcine coronary arteries [33], and human and rat corpus cavernosum [34]. However, there are no previous reports concerning the vasoprotective effect of Ci on the placenta.…”
Section: Introductionmentioning
confidence: 99%
“…With regard to diabetes-related macrovascular and microvascular complications, Ci reduced vascular resistance and stenosis, and protected from hypertension in diabetic rats and mice [28][29][30]. In vivo and in vitro, Ci induced relaxation of rat aorta [31], mice mesenteric arteries [32], porcine coronary arteries [33], and human and rat corpus cavernosum [34]. However, there are no previous reports concerning the vasoprotective effect of Ci on the placenta.…”
Section: Introductionmentioning
confidence: 99%
“…After the identification of the cavernous nerve (CN) and the major right pelvic ganglion, the CN was stimulated (2.5, 5 and 7.5 V, 15 Hz, 30‐s pulse width) with a stainless steel bipolar hook electrode and a square pulse stimulator (Grass Instruments). The measurements were again obtained after CEO (1 µM) and E (1 µM) intracavernosal administration in the diabetic group (Onder, Yilmaz‐Oral, Jarkovic, Akdemir, & Gur, 2019).…”
Section: Methodsmentioning
confidence: 99%
“…All alterations in tension were recorded using an isometric force transducer connected to a PC‐based Data acquisition system (Biopac System). CEO‐ and E (26–104 mg)‐induced relaxant responses were obtained after phenylephrine (Phe, 10 µM) and KCl (60 mM)‐induced pre‐contraction(Halder et al, 2011; Hannigan et al, 2017; Onder et al, 2019; Salahdeen, Idowu, Yemitan, Murtala, & Alada, 2015). After Phe‐induced pre‐contraction (10 µM), CEO‐ and E‐induced relaxation responses were obtained before and after the incubation with nitric oxide synthase (NOS) blocker, L‐ N (G)‐nitroarginine methyl ester (L‐NAME, 100 µM); soluble guanylate cyclase (sGC) blocker, 1H‐[1,2,4]‐oxadiazolo[4,3‐a] quinoxalin‐1‐one (ODQ, 30 µM); L‐type Ca 2+ channel inhibitor, nifedipine (10 µM); nonselective K + channel inhibitor, tetraethylammonium (TEA, 100 µM); and K ATP channel inhibitor, glibenclamide (10 µM).…”
Section: Methodsmentioning
confidence: 99%