Evaluation of Recombinant Human FGF-2 and PDGF-BB in Periodontal Regeneration: A Systematic Review and Meta-Analysis

Abstract

The prognosis for successful treatment of periodontal diseases is generally poor. Current therapeutic strategies often fail to regenerate infected periodontium. Recently an alternative strategy has been developed that combines conventional treatment with the application of recombinant human growth factors (rhGFs). But ambiguities in existed studies on the clinical efficacy of rhGFs do not permit either the identification of the specific growth factors effective for therapeutic interventions or the optimal concentration of them. Neither is it known whether the same rhGF can stimulate regeneration of both soft tissue and bone, or whether different patient populations call for differential use of the growth factors. In order to explore these issues, a meta-analysis was carried out. Particular attention was given to the therapeutic impact of fibroblast growth factor 2(FGF-2) and platelet derived growth factor BB (PDGF-BB). Our findings indicate that 0.3% rhFGF-2 and 0.3 mg/ml rhPDGF-BB show a greater capacity for periodontal regeneration than other concentrations and superiority to control groups with statistical significance. In the case of patients suffering only from gingival recession, however, the application of rhPDGF-BB produces no significant regenerative advantage. The findings of this study can potentially endow clinicians with guidelines for the appropriate application of these two rhGFs.

Mesenchymal stem cells and biologic factors leading to bone formation

“…Furthermore, FGF knockout animals demonstrate a number of developmental osseous abnormalities as well as adverse bone healing and reduced bone formation (Du, Xie, Xian, & Chen, ). Human trials have commenced using FGF to assist repair of bone fractures (Kawaguchi et al., ; Tanaka et al., ) and also for promoting regeneration of periodontal intraosseous defects (Kitamura et al., , , ; Li et al., ) with promising results.…”

A brief history of periodontics in the United States of America: Pioneers and thought‐leaders of the past, and current challenges

“…However, the field has not progressed to the stage where interventions can reliably trigger the regeneration of lost periodontal tissues . Some progress has been made in partial periodontal regeneration using platelet concentrates and recombinant human growth factors . These therapies stimulate residual stem cells at the damaged site to initiate the regenerative process.…”

Comparison between different isoelectric points of biodegradable gelatin sponges incorporating β‐tricalcium phosphate and recombinant human fibroblast growth factor‐2 for ridge augmentation: A preclinical study of saddle‐type defects in dogs

“…Recombinant human fibroblast growth factor‐2 (rhFGF‐2) has been investigated for the treatment of human intrabony periodontal defects . rhFGF‐2 exerts high angiogenic potential and proliferation of undifferentiated mesenchymal cells is induced .…”

“…[7][8][9][10][11] Recombinant human fibroblast growth factor-2 (rhFGF-2) has been investigated for the treatment of human intrabony periodontal defects. [12][13][14][15][16][17][18][19] rhFGF-2 exerts high angiogenic potential and proliferation of undifferentiated mesenchymal cells is induced. 20,21 Moreover, rhFGF-2 signaling plays an essential role in tissue repair and regeneration, especially in terms of osteogenesis.…”